Determinants of genome-wide distribution and evolution of uORFs in eukaryotes

Upstream open reading frames (uORFs) have widespread regulatory functions in eukaryotes, their genomic distribution and evolution is understudied. Here, the authors characterise ~17 million putative uORFs across 478 eukaryotic species, showing how evolution has shaped uORF contents and distribution.

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Autores principales:	Hong Zhang, Yirong Wang, Xinkai Wu, Xiaolu Tang, Changcheng Wu, Jian Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/13fd6825b17a45a79453f599f7700cc2
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spelling	oai:doaj.org-article:13fd6825b17a45a79453f599f7700cc22021-12-02T10:54:04ZDeterminants of genome-wide distribution and evolution of uORFs in eukaryotes10.1038/s41467-021-21394-y2041-1723https://doaj.org/article/13fd6825b17a45a79453f599f7700cc22021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21394-yhttps://doaj.org/toc/2041-1723Upstream open reading frames (uORFs) have widespread regulatory functions in eukaryotes, their genomic distribution and evolution is understudied. Here, the authors characterise ~17 million putative uORFs across 478 eukaryotic species, showing how evolution has shaped uORF contents and distribution.Hong ZhangYirong WangXinkai WuXiaolu TangChangcheng WuJian LuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hong Zhang Yirong Wang Xinkai Wu Xiaolu Tang Changcheng Wu Jian Lu Determinants of genome-wide distribution and evolution of uORFs in eukaryotes
description	Upstream open reading frames (uORFs) have widespread regulatory functions in eukaryotes, their genomic distribution and evolution is understudied. Here, the authors characterise ~17 million putative uORFs across 478 eukaryotic species, showing how evolution has shaped uORF contents and distribution.
format	article
author	Hong Zhang Yirong Wang Xinkai Wu Xiaolu Tang Changcheng Wu Jian Lu
author_facet	Hong Zhang Yirong Wang Xinkai Wu Xiaolu Tang Changcheng Wu Jian Lu
author_sort	Hong Zhang
title	Determinants of genome-wide distribution and evolution of uORFs in eukaryotes
title_short	Determinants of genome-wide distribution and evolution of uORFs in eukaryotes
title_full	Determinants of genome-wide distribution and evolution of uORFs in eukaryotes
title_fullStr	Determinants of genome-wide distribution and evolution of uORFs in eukaryotes
title_full_unstemmed	Determinants of genome-wide distribution and evolution of uORFs in eukaryotes
title_sort	determinants of genome-wide distribution and evolution of uorfs in eukaryotes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/13fd6825b17a45a79453f599f7700cc2
work_keys_str_mv	AT hongzhang determinantsofgenomewidedistributionandevolutionofuorfsineukaryotes AT yirongwang determinantsofgenomewidedistributionandevolutionofuorfsineukaryotes AT xinkaiwu determinantsofgenomewidedistributionandevolutionofuorfsineukaryotes AT xiaolutang determinantsofgenomewidedistributionandevolutionofuorfsineukaryotes AT changchengwu determinantsofgenomewidedistributionandevolutionofuorfsineukaryotes AT jianlu determinantsofgenomewidedistributionandevolutionofuorfsineukaryotes
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Determinants of genome-wide distribution and evolution of uORFs in eukaryotes

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