Paternal-age-related de novo mutations and risk for five disorders

Advanced paternal age associates with increased risk for psychiatric and developmental disorders in offspring. Here, Taylor et al. utilize parent-child trio exome sequencing data sets to estimate the contribution of paternal age-related de novo mutations to multiple disorders, including heart diseas...

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Autores principales:	Jacob L. Taylor, Jean-Christophe P. G. Debost, Sarah U. Morton, Emilie M. Wigdor, Henrike O. Heyne, Dennis Lal, Daniel P. Howrigan, Alex Bloemendal, Janne T. Larsen, Jack A. Kosmicki, Daniel J. Weiner, Jason Homsy, Jonathan G. Seidman, Christine E. Seidman, Esben Agerbo, John J. McGrath, Preben Bo Mortensen, Liselotte Petersen, Mark J. Daly, Elise B. Robinson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/13fdbd2aa6194902a4f369cc6b8b90a5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:13fdbd2aa6194902a4f369cc6b8b90a52021-12-02T16:58:14ZPaternal-age-related de novo mutations and risk for five disorders10.1038/s41467-019-11039-62041-1723https://doaj.org/article/13fdbd2aa6194902a4f369cc6b8b90a52019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11039-6https://doaj.org/toc/2041-1723Advanced paternal age associates with increased risk for psychiatric and developmental disorders in offspring. Here, Taylor et al. utilize parent-child trio exome sequencing data sets to estimate the contribution of paternal age-related de novo mutations to multiple disorders, including heart disease and schizophrenia.Jacob L. TaylorJean-Christophe P. G. DebostSarah U. MortonEmilie M. WigdorHenrike O. HeyneDennis LalDaniel P. HowriganAlex BloemendalJanne T. LarsenJack A. KosmickiDaniel J. WeinerJason HomsyJonathan G. SeidmanChristine E. SeidmanEsben AgerboJohn J. McGrathPreben Bo MortensenLiselotte PetersenMark J. DalyElise B. RobinsonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jacob L. Taylor Jean-Christophe P. G. Debost Sarah U. Morton Emilie M. Wigdor Henrike O. Heyne Dennis Lal Daniel P. Howrigan Alex Bloemendal Janne T. Larsen Jack A. Kosmicki Daniel J. Weiner Jason Homsy Jonathan G. Seidman Christine E. Seidman Esben Agerbo John J. McGrath Preben Bo Mortensen Liselotte Petersen Mark J. Daly Elise B. Robinson Paternal-age-related de novo mutations and risk for five disorders
description	Advanced paternal age associates with increased risk for psychiatric and developmental disorders in offspring. Here, Taylor et al. utilize parent-child trio exome sequencing data sets to estimate the contribution of paternal age-related de novo mutations to multiple disorders, including heart disease and schizophrenia.
format	article
author	Jacob L. Taylor Jean-Christophe P. G. Debost Sarah U. Morton Emilie M. Wigdor Henrike O. Heyne Dennis Lal Daniel P. Howrigan Alex Bloemendal Janne T. Larsen Jack A. Kosmicki Daniel J. Weiner Jason Homsy Jonathan G. Seidman Christine E. Seidman Esben Agerbo John J. McGrath Preben Bo Mortensen Liselotte Petersen Mark J. Daly Elise B. Robinson
author_facet	Jacob L. Taylor Jean-Christophe P. G. Debost Sarah U. Morton Emilie M. Wigdor Henrike O. Heyne Dennis Lal Daniel P. Howrigan Alex Bloemendal Janne T. Larsen Jack A. Kosmicki Daniel J. Weiner Jason Homsy Jonathan G. Seidman Christine E. Seidman Esben Agerbo John J. McGrath Preben Bo Mortensen Liselotte Petersen Mark J. Daly Elise B. Robinson
author_sort	Jacob L. Taylor
title	Paternal-age-related de novo mutations and risk for five disorders
title_short	Paternal-age-related de novo mutations and risk for five disorders
title_full	Paternal-age-related de novo mutations and risk for five disorders
title_fullStr	Paternal-age-related de novo mutations and risk for five disorders
title_full_unstemmed	Paternal-age-related de novo mutations and risk for five disorders
title_sort	paternal-age-related de novo mutations and risk for five disorders
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/13fdbd2aa6194902a4f369cc6b8b90a5
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Paternal-age-related de novo mutations and risk for five disorders

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