Mutation hotspots at CTCF binding sites coupled to chromosomal instability in gastrointestinal cancers

The impact of non-coding somatic mutations in gastric cancer is unknown. Here, using whole genome sequencing data from 212 gastric tumors, the authors identify recurring mutations at specific CTCF binding sites that are common across gastrointestinal cancers and associated with chromosomal instabili...

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Autores principales:	Yu Amanda Guo, Mei Mei Chang, Weitai Huang, Wen Fong Ooi, Manjie Xing, Patrick Tan, Anders Jacobsen Skanderup
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/13feea3481ee460abda9c34ecac0b50f
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spelling	oai:doaj.org-article:13feea3481ee460abda9c34ecac0b50f2021-12-02T14:39:06ZMutation hotspots at CTCF binding sites coupled to chromosomal instability in gastrointestinal cancers10.1038/s41467-018-03828-22041-1723https://doaj.org/article/13feea3481ee460abda9c34ecac0b50f2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03828-2https://doaj.org/toc/2041-1723The impact of non-coding somatic mutations in gastric cancer is unknown. Here, using whole genome sequencing data from 212 gastric tumors, the authors identify recurring mutations at specific CTCF binding sites that are common across gastrointestinal cancers and associated with chromosomal instability.Yu Amanda GuoMei Mei ChangWeitai HuangWen Fong OoiManjie XingPatrick TanAnders Jacobsen SkanderupNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yu Amanda Guo Mei Mei Chang Weitai Huang Wen Fong Ooi Manjie Xing Patrick Tan Anders Jacobsen Skanderup Mutation hotspots at CTCF binding sites coupled to chromosomal instability in gastrointestinal cancers
description	The impact of non-coding somatic mutations in gastric cancer is unknown. Here, using whole genome sequencing data from 212 gastric tumors, the authors identify recurring mutations at specific CTCF binding sites that are common across gastrointestinal cancers and associated with chromosomal instability.
format	article
author	Yu Amanda Guo Mei Mei Chang Weitai Huang Wen Fong Ooi Manjie Xing Patrick Tan Anders Jacobsen Skanderup
author_facet	Yu Amanda Guo Mei Mei Chang Weitai Huang Wen Fong Ooi Manjie Xing Patrick Tan Anders Jacobsen Skanderup
author_sort	Yu Amanda Guo
title	Mutation hotspots at CTCF binding sites coupled to chromosomal instability in gastrointestinal cancers
title_short	Mutation hotspots at CTCF binding sites coupled to chromosomal instability in gastrointestinal cancers
title_full	Mutation hotspots at CTCF binding sites coupled to chromosomal instability in gastrointestinal cancers
title_fullStr	Mutation hotspots at CTCF binding sites coupled to chromosomal instability in gastrointestinal cancers
title_full_unstemmed	Mutation hotspots at CTCF binding sites coupled to chromosomal instability in gastrointestinal cancers
title_sort	mutation hotspots at ctcf binding sites coupled to chromosomal instability in gastrointestinal cancers
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/13feea3481ee460abda9c34ecac0b50f
work_keys_str_mv	AT yuamandaguo mutationhotspotsatctcfbindingsitescoupledtochromosomalinstabilityingastrointestinalcancers AT meimeichang mutationhotspotsatctcfbindingsitescoupledtochromosomalinstabilityingastrointestinalcancers AT weitaihuang mutationhotspotsatctcfbindingsitescoupledtochromosomalinstabilityingastrointestinalcancers AT wenfongooi mutationhotspotsatctcfbindingsitescoupledtochromosomalinstabilityingastrointestinalcancers AT manjiexing mutationhotspotsatctcfbindingsitescoupledtochromosomalinstabilityingastrointestinalcancers AT patricktan mutationhotspotsatctcfbindingsitescoupledtochromosomalinstabilityingastrointestinalcancers AT andersjacobsenskanderup mutationhotspotsatctcfbindingsitescoupledtochromosomalinstabilityingastrointestinalcancers
_version_	1718390698275766272

Mutation hotspots at CTCF binding sites coupled to chromosomal instability in gastrointestinal cancers

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