Self-buffering capacity of a human sulfatase for central nervous system delivery

Self-buffering capacity of a human sulfatase for central nervous system delivery

Abstract Direct delivery of therapeutic enzymes to the Central Nervous System requires stringent formulation design. Not only should the formulation design consider the delicate balance of existing ions, proteins, and osmolality in the cerebrospinal fluid, it must also provide long term efficacy and...

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Autores principales: Yi Wen, Nazila Salamat-Miller, Keethkumar Jain, Katherine Taylor
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/1400d1c04e6a4582b16f39e102a5ed4b
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