Undetected Jawbone Marrow Defects as Inflammatory and Degenerative Signaling Pathways: Chemokine RANTES/CCL5 as a Possible Link Between the Jawbone and Systemic Interactions?

Johann Lechner,1 Marlene Schmidt,2 Volker von Baehr,3 Fabian Schick4 1Head of the Clinic for Integrative Dentistry, Munich, Germany; 2Data Scientist at STEYR Motorenwerke, Steyr, Austria; 3Head of the Department of Immunology and Allergology, Institute for Medical Diagnostics, Berlin, Germany; 4Dent...

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Autores principales:	Lechner J, Schmidt M, von Baehr V, Schick F
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	bone marrow defects jawbone rantes/ccl5 inflammatory signaling pathways silent inflammation systemic immune diseases. Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/1402e8e1e8f447f69c4d7636cfdd3c13
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spelling	oai:doaj.org-article:1402e8e1e8f447f69c4d7636cfdd3c132021-12-02T17:32:13ZUndetected Jawbone Marrow Defects as Inflammatory and Degenerative Signaling Pathways: Chemokine RANTES/CCL5 as a Possible Link Between the Jawbone and Systemic Interactions?1178-7031https://doaj.org/article/1402e8e1e8f447f69c4d7636cfdd3c132021-04-01T00:00:00Zhttps://www.dovepress.com/undetected-jawbone-marrow-defects-as-inflammatory-and-degenerative-sig-peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Johann Lechner,1 Marlene Schmidt,2 Volker von Baehr,3 Fabian Schick4 1Head of the Clinic for Integrative Dentistry, Munich, Germany; 2Data Scientist at STEYR Motorenwerke, Steyr, Austria; 3Head of the Department of Immunology and Allergology, Institute for Medical Diagnostics, Berlin, Germany; 4Dental Surgeon, Clinic for Integrative Dentistry, Munich, GermanyCorrespondence: Johann Lechner Tel +49-89-6970129Fax +49-89-6925830Email drlechner@aol.comBackground: Cytokines, especially chemokines, are of increasing interest in immunology. This study characterizes the little-known phenomenon of “bone marrow defects of the jawbone” (BMDJ) with known overexpression of the chemokine RANTES/CCL5 (R/C).Purpose: Our investigation clarifies why BMDJ and the intensity of local R/C overexpression are challenging to detect, as examined in patients with seven different systemic immunological diseases. Specifically, we investigate whether R/C overexpression is specific to certain disease groups or if it represents a type of signal disruption found in all systemic immunological diseases.Patients and Methods: In a total of 301 patients, BMDJ was surgically repaired during clinical practice to reduce “silent inflammation” associated with the presence of jaw-related pathologies. In each case of BMDJ, bone density was measured preoperatively (in Hounsfield units [HU]), while R/C expression was measured postoperatively. Each of the 301 patients suffered from allergies, atypical facial and trigeminal pain, or were diagnosed with neurodegenerative diseases, tumors, rheumatism, chronic fatigue syndrome, or parasympathetic disorders.Results: In all BMDJ cases, strongly negative HU values indicated decreased bone density or osteolysis. Consistently, all cases of BMDJ showed elevated R/C expression. These findings were consistently observed in every disease group.Discussion: BMDJ was confirmed in all patients, as verified by the HU measurements and laboratory results related to R/C expression. The hypothesis that a specific subset of the seven disease groups could be distinguished either based on the increased presence of BMDJ and by the overexpression of R/C could not be confirmed. A brief literature review confirms the importance of R/C in the etiology of each of the seven disease groups.Conclusion: In this research, the crucial role played by BMDJ and the chemokine R/C in inﬂammatory and immune diseases is discussed for seven groups of patients. Each specific immune disease can be influenced or propelled by BMDJ-derived R/C inflammatory signaling pathways.Keywords: bone marrow defects, jawbone, RANTES/CCL5 inflammatory signaling pathways, silent inflammation, systemic immune diseasesLechner JSchmidt Mvon Baehr VSchick FDove Medical Pressarticlebone marrow defectsjawbonerantes/ccl5 inflammatory signaling pathwayssilent inflammationsystemic immune diseases.PathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 1603-1612 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bone marrow defects jawbone rantes/ccl5 inflammatory signaling pathways silent inflammation systemic immune diseases. Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	bone marrow defects jawbone rantes/ccl5 inflammatory signaling pathways silent inflammation systemic immune diseases. Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Lechner J Schmidt M von Baehr V Schick F Undetected Jawbone Marrow Defects as Inflammatory and Degenerative Signaling Pathways: Chemokine RANTES/CCL5 as a Possible Link Between the Jawbone and Systemic Interactions?
description	Johann Lechner,1 Marlene Schmidt,2 Volker von Baehr,3 Fabian Schick4 1Head of the Clinic for Integrative Dentistry, Munich, Germany; 2Data Scientist at STEYR Motorenwerke, Steyr, Austria; 3Head of the Department of Immunology and Allergology, Institute for Medical Diagnostics, Berlin, Germany; 4Dental Surgeon, Clinic for Integrative Dentistry, Munich, GermanyCorrespondence: Johann Lechner Tel +49-89-6970129Fax +49-89-6925830Email drlechner@aol.comBackground: Cytokines, especially chemokines, are of increasing interest in immunology. This study characterizes the little-known phenomenon of “bone marrow defects of the jawbone” (BMDJ) with known overexpression of the chemokine RANTES/CCL5 (R/C).Purpose: Our investigation clarifies why BMDJ and the intensity of local R/C overexpression are challenging to detect, as examined in patients with seven different systemic immunological diseases. Specifically, we investigate whether R/C overexpression is specific to certain disease groups or if it represents a type of signal disruption found in all systemic immunological diseases.Patients and Methods: In a total of 301 patients, BMDJ was surgically repaired during clinical practice to reduce “silent inflammation” associated with the presence of jaw-related pathologies. In each case of BMDJ, bone density was measured preoperatively (in Hounsfield units [HU]), while R/C expression was measured postoperatively. Each of the 301 patients suffered from allergies, atypical facial and trigeminal pain, or were diagnosed with neurodegenerative diseases, tumors, rheumatism, chronic fatigue syndrome, or parasympathetic disorders.Results: In all BMDJ cases, strongly negative HU values indicated decreased bone density or osteolysis. Consistently, all cases of BMDJ showed elevated R/C expression. These findings were consistently observed in every disease group.Discussion: BMDJ was confirmed in all patients, as verified by the HU measurements and laboratory results related to R/C expression. The hypothesis that a specific subset of the seven disease groups could be distinguished either based on the increased presence of BMDJ and by the overexpression of R/C could not be confirmed. A brief literature review confirms the importance of R/C in the etiology of each of the seven disease groups.Conclusion: In this research, the crucial role played by BMDJ and the chemokine R/C in inﬂammatory and immune diseases is discussed for seven groups of patients. Each specific immune disease can be influenced or propelled by BMDJ-derived R/C inflammatory signaling pathways.Keywords: bone marrow defects, jawbone, RANTES/CCL5 inflammatory signaling pathways, silent inflammation, systemic immune diseases
format	article
author	Lechner J Schmidt M von Baehr V Schick F
author_facet	Lechner J Schmidt M von Baehr V Schick F
author_sort	Lechner J
title	Undetected Jawbone Marrow Defects as Inflammatory and Degenerative Signaling Pathways: Chemokine RANTES/CCL5 as a Possible Link Between the Jawbone and Systemic Interactions?
title_short	Undetected Jawbone Marrow Defects as Inflammatory and Degenerative Signaling Pathways: Chemokine RANTES/CCL5 as a Possible Link Between the Jawbone and Systemic Interactions?
title_full	Undetected Jawbone Marrow Defects as Inflammatory and Degenerative Signaling Pathways: Chemokine RANTES/CCL5 as a Possible Link Between the Jawbone and Systemic Interactions?
title_fullStr	Undetected Jawbone Marrow Defects as Inflammatory and Degenerative Signaling Pathways: Chemokine RANTES/CCL5 as a Possible Link Between the Jawbone and Systemic Interactions?
title_full_unstemmed	Undetected Jawbone Marrow Defects as Inflammatory and Degenerative Signaling Pathways: Chemokine RANTES/CCL5 as a Possible Link Between the Jawbone and Systemic Interactions?
title_sort	undetected jawbone marrow defects as inflammatory and degenerative signaling pathways: chemokine rantes/ccl5 as a possible link between the jawbone and systemic interactions?
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/1402e8e1e8f447f69c4d7636cfdd3c13
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Undetected Jawbone Marrow Defects as Inflammatory and Degenerative Signaling Pathways: Chemokine RANTES/CCL5 as a Possible Link Between the Jawbone and Systemic Interactions?

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