Influenza A (H1N1) in Victoria, Australia: a community case series and analysis of household transmission.

<h4>Background</h4>We characterise the clinical features and household transmission of pandemic influenza A (pH1N1) in community cases from Victoria, Australia in 2009.<h4>Methods</h4>Questionnaires were used to collect information on epidemiological characteristics, illness...

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Autores principales:	Clare Looker, Kylie Carville, Kristina Grant, Heath Kelly
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/14033076ca75429bb5e06b4734f21cb3
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spelling	oai:doaj.org-article:14033076ca75429bb5e06b4734f21cb32021-11-18T07:02:42ZInfluenza A (H1N1) in Victoria, Australia: a community case series and analysis of household transmission.1932-620310.1371/journal.pone.0013702https://doaj.org/article/14033076ca75429bb5e06b4734f21cb32010-10-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21060887/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>We characterise the clinical features and household transmission of pandemic influenza A (pH1N1) in community cases from Victoria, Australia in 2009.<h4>Methods</h4>Questionnaires were used to collect information on epidemiological characteristics, illness features and co-morbidities of cases identified in the 2009 Victorian Influenza Sentinel Surveillance program.<h4>Results</h4>The median age of 132 index cases was 21 years, of whom 54 (41%) were under 18 years old and 28 (21%) had medical co-morbidities. The median symptom duration was significantly shorter for children who received antivirals than in those who did not (p = 0.03). Assumed influenza transmission was observed in 63 (51%) households. Influenza-like illness (ILI) developed in 115 of 351 household contacts, a crude secondary attack rate of 33%. Increased ILI rates were seen in households with larger numbers of children but not larger numbers of adults. Multivariate analysis indicated contacts of cases with cough and diarrhoea, and contacts in quarantined households were significantly more likely to develop influenza-like symptoms.<h4>Conclusion</h4>Most cases of pH1N1 in our study were mild with similar clinical characteristics to seasonal influenza. Illness and case features relating to virus excretion, age and household quarantine may have influenced secondary ILI rates within households.Clare LookerKylie CarvilleKristina GrantHeath KellyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 10, p e13702 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Clare Looker Kylie Carville Kristina Grant Heath Kelly Influenza A (H1N1) in Victoria, Australia: a community case series and analysis of household transmission.
description	<h4>Background</h4>We characterise the clinical features and household transmission of pandemic influenza A (pH1N1) in community cases from Victoria, Australia in 2009.<h4>Methods</h4>Questionnaires were used to collect information on epidemiological characteristics, illness features and co-morbidities of cases identified in the 2009 Victorian Influenza Sentinel Surveillance program.<h4>Results</h4>The median age of 132 index cases was 21 years, of whom 54 (41%) were under 18 years old and 28 (21%) had medical co-morbidities. The median symptom duration was significantly shorter for children who received antivirals than in those who did not (p = 0.03). Assumed influenza transmission was observed in 63 (51%) households. Influenza-like illness (ILI) developed in 115 of 351 household contacts, a crude secondary attack rate of 33%. Increased ILI rates were seen in households with larger numbers of children but not larger numbers of adults. Multivariate analysis indicated contacts of cases with cough and diarrhoea, and contacts in quarantined households were significantly more likely to develop influenza-like symptoms.<h4>Conclusion</h4>Most cases of pH1N1 in our study were mild with similar clinical characteristics to seasonal influenza. Illness and case features relating to virus excretion, age and household quarantine may have influenced secondary ILI rates within households.
format	article
author	Clare Looker Kylie Carville Kristina Grant Heath Kelly
author_facet	Clare Looker Kylie Carville Kristina Grant Heath Kelly
author_sort	Clare Looker
title	Influenza A (H1N1) in Victoria, Australia: a community case series and analysis of household transmission.
title_short	Influenza A (H1N1) in Victoria, Australia: a community case series and analysis of household transmission.
title_full	Influenza A (H1N1) in Victoria, Australia: a community case series and analysis of household transmission.
title_fullStr	Influenza A (H1N1) in Victoria, Australia: a community case series and analysis of household transmission.
title_full_unstemmed	Influenza A (H1N1) in Victoria, Australia: a community case series and analysis of household transmission.
title_sort	influenza a (h1n1) in victoria, australia: a community case series and analysis of household transmission.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/14033076ca75429bb5e06b4734f21cb3
work_keys_str_mv	AT clarelooker influenzaah1n1invictoriaaustraliaacommunitycaseseriesandanalysisofhouseholdtransmission AT kyliecarville influenzaah1n1invictoriaaustraliaacommunitycaseseriesandanalysisofhouseholdtransmission AT kristinagrant influenzaah1n1invictoriaaustraliaacommunitycaseseriesandanalysisofhouseholdtransmission AT heathkelly influenzaah1n1invictoriaaustraliaacommunitycaseseriesandanalysisofhouseholdtransmission
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Influenza A (H1N1) in Victoria, Australia: a community case series and analysis of household transmission.

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