On the centenary of the insulin discovery

The discovery of insulin and the beginning of its use in 1921–1922 made a revolution in endocrinology and in medicine in general. This significant event gave millions of patients with diabetes not only the opportunity to live, but also the hope that their life with this disease would be full.The art...

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Autores principales:	I. I. Dedov, M. V. Shestakova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2021
Materias:	insulin 100 years analogues Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/14036340f3c147e9b259090498e84f2d
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id	oai:doaj.org-article:14036340f3c147e9b259090498e84f2d
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spelling	oai:doaj.org-article:14036340f3c147e9b259090498e84f2d2021-11-14T09:00:23ZOn the centenary of the insulin discovery2072-03512072-037810.14341/DM12733https://doaj.org/article/14036340f3c147e9b259090498e84f2d2021-02-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/12733https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378The discovery of insulin and the beginning of its use in 1921–1922 made a revolution in endocrinology and in medicine in general. This significant event gave millions of patients with diabetes not only the opportunity to live, but also the hope that their life with this disease would be full.The article examines the history of insulin discovery, as well as the evolution of several generations of insulin preparations and the advantages of each of the generations that have radically changed not only life expectancy, but also its quality.The first generation — insulins of animal origin and the solution of the first tasks of their sufficient production and purification. The next generation is human insulins, the purification of which was also a problem. The third generation is insulin analogues, the action of which became closer to the action profile of natural insulin. And the last generation — insulin analogues, most closely mimicking the action of endogenous insulin.Along with the development of insulin preparations, the article traces the evolution of the devices of its administration.I. I. DedovM. V. ShestakovaEndocrinology Research Centrearticleinsulin100 yearsanaloguesNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 24, Iss 1, Pp 11-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	insulin 100 years analogues Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	insulin 100 years analogues Nutritional diseases. Deficiency diseases RC620-627 I. I. Dedov M. V. Shestakova On the centenary of the insulin discovery
description	The discovery of insulin and the beginning of its use in 1921–1922 made a revolution in endocrinology and in medicine in general. This significant event gave millions of patients with diabetes not only the opportunity to live, but also the hope that their life with this disease would be full.The article examines the history of insulin discovery, as well as the evolution of several generations of insulin preparations and the advantages of each of the generations that have radically changed not only life expectancy, but also its quality.The first generation — insulins of animal origin and the solution of the first tasks of their sufficient production and purification. The next generation is human insulins, the purification of which was also a problem. The third generation is insulin analogues, the action of which became closer to the action profile of natural insulin. And the last generation — insulin analogues, most closely mimicking the action of endogenous insulin.Along with the development of insulin preparations, the article traces the evolution of the devices of its administration.
format	article
author	I. I. Dedov M. V. Shestakova
author_facet	I. I. Dedov M. V. Shestakova
author_sort	I. I. Dedov
title	On the centenary of the insulin discovery
title_short	On the centenary of the insulin discovery
title_full	On the centenary of the insulin discovery
title_fullStr	On the centenary of the insulin discovery
title_full_unstemmed	On the centenary of the insulin discovery
title_sort	on the centenary of the insulin discovery
publisher	Endocrinology Research Centre
publishDate	2021
url	https://doaj.org/article/14036340f3c147e9b259090498e84f2d
work_keys_str_mv	AT iidedov onthecentenaryoftheinsulindiscovery AT mvshestakova onthecentenaryoftheinsulindiscovery
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On the centenary of the insulin discovery

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