The Relationship between Serum Insulin-Like Growth Factor-1 Levels and Body Composition Changes after Sleeve Gastrectomy

Introduction: We previously reported that preoperative serum insulin-like growth factor-1 (IGF-1) is a predictor of total weight loss percentage (%TWL) after laparoscopic sleeve gastrectomy (LSG). IGF-1 may suppress muscle loss after surgery. IGF-1 almost accurately reflects the growth hormone (GH)...

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Autores principales:	Masahiro Ohira, Yasuhiro Watanabe, Takashi Yamaguchi, Hiroki Onda, Shuhei Yamaoka, Kazuki Abe, Shoko Nakamura, Shou Tanaka, Naoyuki Kawagoe, Taiki Nabekura, Atsuhito Saiki, Takashi Oshiro, Daiji Nagayama, Ichiro Tatsuno
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	laparoscopic sleeve gastrectomy insulin-like growth factor-1 obesity body fat skeletal muscle Nutrition. Foods and food supply TX341-641 Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/1404a8903d364bafa29f5386e3798c51
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spelling	oai:doaj.org-article:1404a8903d364bafa29f5386e3798c512021-11-11T10:40:44ZThe Relationship between Serum Insulin-Like Growth Factor-1 Levels and Body Composition Changes after Sleeve Gastrectomy1662-40251662-403310.1159/000519610https://doaj.org/article/1404a8903d364bafa29f5386e3798c512021-10-01T00:00:00Zhttps://www.karger.com/Article/FullText/519610https://doaj.org/toc/1662-4025https://doaj.org/toc/1662-4033Introduction: We previously reported that preoperative serum insulin-like growth factor-1 (IGF-1) is a predictor of total weight loss percentage (%TWL) after laparoscopic sleeve gastrectomy (LSG). IGF-1 may suppress muscle loss after surgery. IGF-1 almost accurately reflects the growth hormone (GH) secretion status, and GH has lipolytic effects. Therefore, IGF-1 may influence both the maintenance of skeletal muscle and the reduction of adipose tissue after LSG. The identification of the relationship between preoperative serum IGF-1 and body composition changes after LSG can help in understanding the pathophysiology of obesity. Methods: We retrospectively reviewed 72 patients with obesity who underwent LSG and were followed up for 12 months. We analyzed the relationship between preoperative serum IGF-1 levels and body composition changes after LSG. A multiple regression model was used. Results: LSG led to a significant reduction in body weight. Both body fat mass and skeletal muscle mass decreased after LSG. Preoperative serum IGF-1 levels significantly correlated with %TWL, changes in skeletal muscle mass, and body fat mass after LSG. The multiple regression model showed that preoperative serum IGF-1 levels were related to decreased body fat mass and maintaining skeletal muscle mass after LSG. Discussion/Conclusion: Preoperative IGF-1 measurement helps predict not only successful weight loss but also decreases body fat mass and maintains skeletal muscle mass after LSG.Masahiro OhiraYasuhiro WatanabeTakashi YamaguchiHiroki OndaShuhei YamaokaKazuki AbeShoko NakamuraShou TanakaNaoyuki KawagoeTaiki NabekuraAtsuhito SaikiTakashi OshiroDaiji NagayamaIchiro TatsunoKarger Publishersarticlelaparoscopic sleeve gastrectomyinsulin-like growth factor-1obesitybody fatskeletal muscleNutrition. Foods and food supplyTX341-641Nutritional diseases. Deficiency diseasesRC620-627ENObesity Facts, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	laparoscopic sleeve gastrectomy insulin-like growth factor-1 obesity body fat skeletal muscle Nutrition. Foods and food supply TX341-641 Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	laparoscopic sleeve gastrectomy insulin-like growth factor-1 obesity body fat skeletal muscle Nutrition. Foods and food supply TX341-641 Nutritional diseases. Deficiency diseases RC620-627 Masahiro Ohira Yasuhiro Watanabe Takashi Yamaguchi Hiroki Onda Shuhei Yamaoka Kazuki Abe Shoko Nakamura Shou Tanaka Naoyuki Kawagoe Taiki Nabekura Atsuhito Saiki Takashi Oshiro Daiji Nagayama Ichiro Tatsuno The Relationship between Serum Insulin-Like Growth Factor-1 Levels and Body Composition Changes after Sleeve Gastrectomy
description	Introduction: We previously reported that preoperative serum insulin-like growth factor-1 (IGF-1) is a predictor of total weight loss percentage (%TWL) after laparoscopic sleeve gastrectomy (LSG). IGF-1 may suppress muscle loss after surgery. IGF-1 almost accurately reflects the growth hormone (GH) secretion status, and GH has lipolytic effects. Therefore, IGF-1 may influence both the maintenance of skeletal muscle and the reduction of adipose tissue after LSG. The identification of the relationship between preoperative serum IGF-1 and body composition changes after LSG can help in understanding the pathophysiology of obesity. Methods: We retrospectively reviewed 72 patients with obesity who underwent LSG and were followed up for 12 months. We analyzed the relationship between preoperative serum IGF-1 levels and body composition changes after LSG. A multiple regression model was used. Results: LSG led to a significant reduction in body weight. Both body fat mass and skeletal muscle mass decreased after LSG. Preoperative serum IGF-1 levels significantly correlated with %TWL, changes in skeletal muscle mass, and body fat mass after LSG. The multiple regression model showed that preoperative serum IGF-1 levels were related to decreased body fat mass and maintaining skeletal muscle mass after LSG. Discussion/Conclusion: Preoperative IGF-1 measurement helps predict not only successful weight loss but also decreases body fat mass and maintains skeletal muscle mass after LSG.
format	article
author	Masahiro Ohira Yasuhiro Watanabe Takashi Yamaguchi Hiroki Onda Shuhei Yamaoka Kazuki Abe Shoko Nakamura Shou Tanaka Naoyuki Kawagoe Taiki Nabekura Atsuhito Saiki Takashi Oshiro Daiji Nagayama Ichiro Tatsuno
author_facet	Masahiro Ohira Yasuhiro Watanabe Takashi Yamaguchi Hiroki Onda Shuhei Yamaoka Kazuki Abe Shoko Nakamura Shou Tanaka Naoyuki Kawagoe Taiki Nabekura Atsuhito Saiki Takashi Oshiro Daiji Nagayama Ichiro Tatsuno
author_sort	Masahiro Ohira
title	The Relationship between Serum Insulin-Like Growth Factor-1 Levels and Body Composition Changes after Sleeve Gastrectomy
title_short	The Relationship between Serum Insulin-Like Growth Factor-1 Levels and Body Composition Changes after Sleeve Gastrectomy
title_full	The Relationship between Serum Insulin-Like Growth Factor-1 Levels and Body Composition Changes after Sleeve Gastrectomy
title_fullStr	The Relationship between Serum Insulin-Like Growth Factor-1 Levels and Body Composition Changes after Sleeve Gastrectomy
title_full_unstemmed	The Relationship between Serum Insulin-Like Growth Factor-1 Levels and Body Composition Changes after Sleeve Gastrectomy
title_sort	relationship between serum insulin-like growth factor-1 levels and body composition changes after sleeve gastrectomy
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/1404a8903d364bafa29f5386e3798c51
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The Relationship between Serum Insulin-Like Growth Factor-1 Levels and Body Composition Changes after Sleeve Gastrectomy

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