Lesion of the hippocampus selectively enhances LEC’s activity during recognition memory based on familiarity

Abstract The sense of familiarity for events is crucial for successful recognition memory. However, the neural substrate and mechanisms supporting familiarity remain unclear. A major controversy in memory research is whether the parahippocampal areas, especially the lateral entorhinal (LEC) and the...

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Autores principales:	Liv Mahnke, Erika Atucha, Eneko Pina-Fernàndez, Takashi Kitsukawa, Magdalena M. Sauvage
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/140504ea2ab243f68d310ee4bdc4d3ed
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spelling	oai:doaj.org-article:140504ea2ab243f68d310ee4bdc4d3ed2021-12-02T17:17:38ZLesion of the hippocampus selectively enhances LEC’s activity during recognition memory based on familiarity10.1038/s41598-021-98509-42045-2322https://doaj.org/article/140504ea2ab243f68d310ee4bdc4d3ed2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98509-4https://doaj.org/toc/2045-2322Abstract The sense of familiarity for events is crucial for successful recognition memory. However, the neural substrate and mechanisms supporting familiarity remain unclear. A major controversy in memory research is whether the parahippocampal areas, especially the lateral entorhinal (LEC) and the perirhinal (PER) cortices, support familiarity or whether the hippocampus (HIP) does. In addition, it is unclear if LEC, PER and HIP interact within this frame. Here, we especially investigate if LEC and PER's contribution to familiarity depends on hippocampal integrity. To do so, we compare LEC and PER neural activity between rats with intact hippocampus performing on a human to rat translational task relying on both recollection and familiarity and rats with hippocampal lesions that have been shown to then rely on familiarity to perform the same task. Using high resolution Immediate Early Gene imaging, we report that hippocampal lesions enhance activity in LEC during familiarity judgments but not PER’s. These findings suggest that different mechanisms support familiarity in LEC and PER and led to the hypothesis that HIP might exert a tonic inhibition on LEC during recognition memory that is released when HIP is compromised, possibly constituting a compensatory mechanism in aging and amnesic patients.Liv MahnkeErika AtuchaEneko Pina-FernàndezTakashi KitsukawaMagdalena M. SauvageNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Liv Mahnke Erika Atucha Eneko Pina-Fernàndez Takashi Kitsukawa Magdalena M. Sauvage Lesion of the hippocampus selectively enhances LEC’s activity during recognition memory based on familiarity
description	Abstract The sense of familiarity for events is crucial for successful recognition memory. However, the neural substrate and mechanisms supporting familiarity remain unclear. A major controversy in memory research is whether the parahippocampal areas, especially the lateral entorhinal (LEC) and the perirhinal (PER) cortices, support familiarity or whether the hippocampus (HIP) does. In addition, it is unclear if LEC, PER and HIP interact within this frame. Here, we especially investigate if LEC and PER's contribution to familiarity depends on hippocampal integrity. To do so, we compare LEC and PER neural activity between rats with intact hippocampus performing on a human to rat translational task relying on both recollection and familiarity and rats with hippocampal lesions that have been shown to then rely on familiarity to perform the same task. Using high resolution Immediate Early Gene imaging, we report that hippocampal lesions enhance activity in LEC during familiarity judgments but not PER’s. These findings suggest that different mechanisms support familiarity in LEC and PER and led to the hypothesis that HIP might exert a tonic inhibition on LEC during recognition memory that is released when HIP is compromised, possibly constituting a compensatory mechanism in aging and amnesic patients.
format	article
author	Liv Mahnke Erika Atucha Eneko Pina-Fernàndez Takashi Kitsukawa Magdalena M. Sauvage
author_facet	Liv Mahnke Erika Atucha Eneko Pina-Fernàndez Takashi Kitsukawa Magdalena M. Sauvage
author_sort	Liv Mahnke
title	Lesion of the hippocampus selectively enhances LEC’s activity during recognition memory based on familiarity
title_short	Lesion of the hippocampus selectively enhances LEC’s activity during recognition memory based on familiarity
title_full	Lesion of the hippocampus selectively enhances LEC’s activity during recognition memory based on familiarity
title_fullStr	Lesion of the hippocampus selectively enhances LEC’s activity during recognition memory based on familiarity
title_full_unstemmed	Lesion of the hippocampus selectively enhances LEC’s activity during recognition memory based on familiarity
title_sort	lesion of the hippocampus selectively enhances lec’s activity during recognition memory based on familiarity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/140504ea2ab243f68d310ee4bdc4d3ed
work_keys_str_mv	AT livmahnke lesionofthehippocampusselectivelyenhanceslecsactivityduringrecognitionmemorybasedonfamiliarity AT erikaatucha lesionofthehippocampusselectivelyenhanceslecsactivityduringrecognitionmemorybasedonfamiliarity AT enekopinafernandez lesionofthehippocampusselectivelyenhanceslecsactivityduringrecognitionmemorybasedonfamiliarity AT takashikitsukawa lesionofthehippocampusselectivelyenhanceslecsactivityduringrecognitionmemorybasedonfamiliarity AT magdalenamsauvage lesionofthehippocampusselectivelyenhanceslecsactivityduringrecognitionmemorybasedonfamiliarity
_version_	1718381128532885504

Lesion of the hippocampus selectively enhances LEC’s activity during recognition memory based on familiarity

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