Impact of single-walled carbon nanotubes on the embryo: a brief review

Ala-Eddin Al Moustafa,1–4 Etienne Mfoumou,5 Dacian E Roman,3 Vahe Nerguizian,6 Anas Alazzam,7 Ion Stiharu,3 Amber Yasmeen8 1College of Medicine & Biomedical Research Centre, Qatar University, Doha, Qatar; 2Oncology Department, McGill University, 3Mechanical and Industrial Engineeri...

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Autores principales:	Al Moustafa AE, Mfoumou E, Roman DE, Nerguizian V, Alazzam A, Stiharu I, Yasmeen A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Single-walled carbon nanotubes Embryo Toxicity Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/14053b72644147b7a2d4d311d98e250d
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spelling	oai:doaj.org-article:14053b72644147b7a2d4d311d98e250d2021-12-02T02:15:58ZImpact of single-walled carbon nanotubes on the embryo: a brief review1178-2013https://doaj.org/article/14053b72644147b7a2d4d311d98e250d2016-01-01T00:00:00Zhttps://www.dovepress.com/impact-of-single-walled-carbon-nanotubes-on-the-embryo-a-brief-review-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Ala-Eddin Al Moustafa,1–4 Etienne Mfoumou,5 Dacian E Roman,3 Vahe Nerguizian,6 Anas Alazzam,7 Ion Stiharu,3 Amber Yasmeen8 1College of Medicine & Biomedical Research Centre, Qatar University, Doha, Qatar; 2Oncology Department, McGill University, 3Mechanical and Industrial Engineering Department, Concordia University, Montreal, QC, Canada; 4Syrian Research Cancer Centre of the Syrian Society against Cancer, Aleppo, Syria; 5Nova Scotia Community College, Dartmouth, NS, 6École de Technologie Supérieure, Montreal, QC, Canada; 7Department of Mechanical Engineering, Khalifa University, Abu Dhabi, UAE; 8Segal Cancer Centre, Lady Davis Institute for Medical Research of the Sir Mortimer B. Davis-Jewish General Hospital, Montreal, QC, Canada Abstract: Carbon nanotubes (CNTs) are considered one of the most interesting materials in the 21st century due to their unique physiochemical characteristics and applicability to various industrial products and medical applications. However, in the last few years, questions have been raised regarding the potential toxicity of CNTs to humans and the environment; it is believed that the physiochemical characteristics of these materials are key determinants of CNT interaction with living cells and hence determine their toxicity in humans and other organisms as well as their embryos. Thus, several recent studies, including ours, pointed out that CNTs have cytotoxic effects on human and animal cells, which occur via the alteration of key regulator genes of cell proliferation, apoptosis, survival, cell–cell adhesion, and angiogenesis. Meanwhile, few investigations revealed that CNTs could also be harmful to the normal development of the embryo. In this review, we will discuss the toxic role of single-walled CNTs in the embryo, which was recently explored by several groups including ours. Keywords: single-walled carbon nanotubes, embryo, toxicityAl Moustafa AEMfoumou ERoman DENerguizian VAlazzam AStiharu IYasmeen ADove Medical PressarticleSingle-walled carbon nanotubesEmbryoToxicityMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss Issue 1, Pp 349-355 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Single-walled carbon nanotubes Embryo Toxicity Medicine (General) R5-920
spellingShingle	Single-walled carbon nanotubes Embryo Toxicity Medicine (General) R5-920 Al Moustafa AE Mfoumou E Roman DE Nerguizian V Alazzam A Stiharu I Yasmeen A Impact of single-walled carbon nanotubes on the embryo: a brief review
description	Ala-Eddin Al Moustafa,1–4 Etienne Mfoumou,5 Dacian E Roman,3 Vahe Nerguizian,6 Anas Alazzam,7 Ion Stiharu,3 Amber Yasmeen8 1College of Medicine & Biomedical Research Centre, Qatar University, Doha, Qatar; 2Oncology Department, McGill University, 3Mechanical and Industrial Engineering Department, Concordia University, Montreal, QC, Canada; 4Syrian Research Cancer Centre of the Syrian Society against Cancer, Aleppo, Syria; 5Nova Scotia Community College, Dartmouth, NS, 6École de Technologie Supérieure, Montreal, QC, Canada; 7Department of Mechanical Engineering, Khalifa University, Abu Dhabi, UAE; 8Segal Cancer Centre, Lady Davis Institute for Medical Research of the Sir Mortimer B. Davis-Jewish General Hospital, Montreal, QC, Canada Abstract: Carbon nanotubes (CNTs) are considered one of the most interesting materials in the 21st century due to their unique physiochemical characteristics and applicability to various industrial products and medical applications. However, in the last few years, questions have been raised regarding the potential toxicity of CNTs to humans and the environment; it is believed that the physiochemical characteristics of these materials are key determinants of CNT interaction with living cells and hence determine their toxicity in humans and other organisms as well as their embryos. Thus, several recent studies, including ours, pointed out that CNTs have cytotoxic effects on human and animal cells, which occur via the alteration of key regulator genes of cell proliferation, apoptosis, survival, cell–cell adhesion, and angiogenesis. Meanwhile, few investigations revealed that CNTs could also be harmful to the normal development of the embryo. In this review, we will discuss the toxic role of single-walled CNTs in the embryo, which was recently explored by several groups including ours. Keywords: single-walled carbon nanotubes, embryo, toxicity
format	article
author	Al Moustafa AE Mfoumou E Roman DE Nerguizian V Alazzam A Stiharu I Yasmeen A
author_facet	Al Moustafa AE Mfoumou E Roman DE Nerguizian V Alazzam A Stiharu I Yasmeen A
author_sort	Al Moustafa AE
title	Impact of single-walled carbon nanotubes on the embryo: a brief review
title_short	Impact of single-walled carbon nanotubes on the embryo: a brief review
title_full	Impact of single-walled carbon nanotubes on the embryo: a brief review
title_fullStr	Impact of single-walled carbon nanotubes on the embryo: a brief review
title_full_unstemmed	Impact of single-walled carbon nanotubes on the embryo: a brief review
title_sort	impact of single-walled carbon nanotubes on the embryo: a brief review
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/14053b72644147b7a2d4d311d98e250d
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Impact of single-walled carbon nanotubes on the embryo: a brief review

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