The functional upregulation of piriform cortex is associated with cross-modal plasticity in loss of whisker tactile inputs.
<h4>Background</h4>Cross-modal plasticity is characterized as the hypersensitivity of remaining modalities after a sensory function is lost in rodents, which ensures their awareness to environmental changes. Cellular and molecular mechanisms underlying cross-modal sensory plasticity rema...
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2012
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oai:doaj.org-article:140b93f069c240b8a45e525699d74af02021-11-18T07:08:08ZThe functional upregulation of piriform cortex is associated with cross-modal plasticity in loss of whisker tactile inputs.1932-620310.1371/journal.pone.0041986https://doaj.org/article/140b93f069c240b8a45e525699d74af02012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22927919/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Cross-modal plasticity is characterized as the hypersensitivity of remaining modalities after a sensory function is lost in rodents, which ensures their awareness to environmental changes. Cellular and molecular mechanisms underlying cross-modal sensory plasticity remain unclear. We aim to study the role of different types of neurons in cross-modal plasticity.<h4>Methodology/principal findings</h4>In addition to behavioral tasks in mice, whole-cell recordings at the excitatory and inhibitory neurons, and their two-photon imaging, were conducted in piriform cortex. We produced a mouse model of cross-modal sensory plasticity that olfactory function was upregulated by trimming whiskers to deprive their sensory inputs. In the meantime of olfactory hypersensitivity, pyramidal neurons and excitatory synapses were functionally upregulated, as well as GABAergic cells and inhibitory synapses were downregulated in piriform cortex from the mice of cross-modal sensory plasticity, compared with controls. A crosswire connection between barrel cortex and piriform cortex was established in cross-modal plasticity.<h4>Conclusion/significance</h4>An upregulation of pyramidal neurons and a downregulation of GABAergic neurons strengthen the activities of neuronal networks in piriform cortex, which may be responsible for olfactory hypersensitivity after a loss of whisker tactile input. This finding provides the clues for developing therapeutic strategies to promote sensory recovery and substitution.Bing YeLi HuangZilong GaoPing ChenHong NiSudong GuanYan ZhuJin-Hui WangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e41986 (2012) |
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Medicine R Science Q Bing Ye Li Huang Zilong Gao Ping Chen Hong Ni Sudong Guan Yan Zhu Jin-Hui Wang The functional upregulation of piriform cortex is associated with cross-modal plasticity in loss of whisker tactile inputs. |
| description |
<h4>Background</h4>Cross-modal plasticity is characterized as the hypersensitivity of remaining modalities after a sensory function is lost in rodents, which ensures their awareness to environmental changes. Cellular and molecular mechanisms underlying cross-modal sensory plasticity remain unclear. We aim to study the role of different types of neurons in cross-modal plasticity.<h4>Methodology/principal findings</h4>In addition to behavioral tasks in mice, whole-cell recordings at the excitatory and inhibitory neurons, and their two-photon imaging, were conducted in piriform cortex. We produced a mouse model of cross-modal sensory plasticity that olfactory function was upregulated by trimming whiskers to deprive their sensory inputs. In the meantime of olfactory hypersensitivity, pyramidal neurons and excitatory synapses were functionally upregulated, as well as GABAergic cells and inhibitory synapses were downregulated in piriform cortex from the mice of cross-modal sensory plasticity, compared with controls. A crosswire connection between barrel cortex and piriform cortex was established in cross-modal plasticity.<h4>Conclusion/significance</h4>An upregulation of pyramidal neurons and a downregulation of GABAergic neurons strengthen the activities of neuronal networks in piriform cortex, which may be responsible for olfactory hypersensitivity after a loss of whisker tactile input. This finding provides the clues for developing therapeutic strategies to promote sensory recovery and substitution. |
| format |
article |
| author |
Bing Ye Li Huang Zilong Gao Ping Chen Hong Ni Sudong Guan Yan Zhu Jin-Hui Wang |
| author_facet |
Bing Ye Li Huang Zilong Gao Ping Chen Hong Ni Sudong Guan Yan Zhu Jin-Hui Wang |
| author_sort |
Bing Ye |
| title |
The functional upregulation of piriform cortex is associated with cross-modal plasticity in loss of whisker tactile inputs. |
| title_short |
The functional upregulation of piriform cortex is associated with cross-modal plasticity in loss of whisker tactile inputs. |
| title_full |
The functional upregulation of piriform cortex is associated with cross-modal plasticity in loss of whisker tactile inputs. |
| title_fullStr |
The functional upregulation of piriform cortex is associated with cross-modal plasticity in loss of whisker tactile inputs. |
| title_full_unstemmed |
The functional upregulation of piriform cortex is associated with cross-modal plasticity in loss of whisker tactile inputs. |
| title_sort |
functional upregulation of piriform cortex is associated with cross-modal plasticity in loss of whisker tactile inputs. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/140b93f069c240b8a45e525699d74af0 |
| work_keys_str_mv |
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