Structural alteration of the dorsal visual network in DLB patients with visual hallucinations: a cortical thickness MRI study.

Visual hallucinations (VH) represent one of the core features in discriminating dementia with Lewy bodies (DLB) from Alzheimer's Disease (AD). Previous studies reported that in DLB patients functional alterations of the parieto-occipital regions were correlated with the presence of VH. The aim...

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Autores principales:	Stefano Delli Pizzi, Raffaella Franciotti, Armando Tartaro, Massimo Caulo, Astrid Thomas, Marco Onofrj, Laura Bonanni
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/140bdc0239234aceb73d0e964bf72acb
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spelling	oai:doaj.org-article:140bdc0239234aceb73d0e964bf72acb2021-11-18T08:36:06ZStructural alteration of the dorsal visual network in DLB patients with visual hallucinations: a cortical thickness MRI study.1932-620310.1371/journal.pone.0086624https://doaj.org/article/140bdc0239234aceb73d0e964bf72acb2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24466177/?tool=EBIhttps://doaj.org/toc/1932-6203Visual hallucinations (VH) represent one of the core features in discriminating dementia with Lewy bodies (DLB) from Alzheimer's Disease (AD). Previous studies reported that in DLB patients functional alterations of the parieto-occipital regions were correlated with the presence of VH. The aim of our study was to assess whether morphological changes in specific cortical regions of DLB could be related to the presence and severity of VH. We performed a cortical thickness analysis on magnetic resonance imaging data in a cohort including 18 DLB patients, 15 AD patients and 14 healthy control subjects. Relatively to DLB group, correlation analysis between the cortical thickness and the Neuropsychiatric Inventory (NPI) hallucination item scores was also performed. Cortical thickness was reduced bilaterally in DLB compared to controls in the pericalcarine and lingual gyri, cuneus, precuneus, superior parietal gyrus. Cortical thinning was found bilaterally in AD compared to controls in temporal cortex including the superior and middle temporal gyrus, part of inferior temporal cortex, temporal pole and insula. Inferior parietal and supramarginal gyri were also affected bilaterally in AD as compared to controls. The comparison between DLB and AD evidenced cortical thinning in DLB group in the right posterior regions including superior parietal gyrus, precuneus, cuneus, pericalcarine and lingual gyri. Furthermore, the correlation analysis between cortical thickness and NPI hallucination item scores showed that the structural alteration in the dorsal visual regions including superior parietal gyrus and precuneus closely correlated with the occurrence and severity of VH. We suggest that structural changes in key regions of the dorsal visual network may play a crucial role in the physiopathology of VH in DLB patients.Stefano Delli PizziRaffaella FranciottiArmando TartaroMassimo CauloAstrid ThomasMarco OnofrjLaura BonanniPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e86624 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Stefano Delli Pizzi Raffaella Franciotti Armando Tartaro Massimo Caulo Astrid Thomas Marco Onofrj Laura Bonanni Structural alteration of the dorsal visual network in DLB patients with visual hallucinations: a cortical thickness MRI study.
description	Visual hallucinations (VH) represent one of the core features in discriminating dementia with Lewy bodies (DLB) from Alzheimer's Disease (AD). Previous studies reported that in DLB patients functional alterations of the parieto-occipital regions were correlated with the presence of VH. The aim of our study was to assess whether morphological changes in specific cortical regions of DLB could be related to the presence and severity of VH. We performed a cortical thickness analysis on magnetic resonance imaging data in a cohort including 18 DLB patients, 15 AD patients and 14 healthy control subjects. Relatively to DLB group, correlation analysis between the cortical thickness and the Neuropsychiatric Inventory (NPI) hallucination item scores was also performed. Cortical thickness was reduced bilaterally in DLB compared to controls in the pericalcarine and lingual gyri, cuneus, precuneus, superior parietal gyrus. Cortical thinning was found bilaterally in AD compared to controls in temporal cortex including the superior and middle temporal gyrus, part of inferior temporal cortex, temporal pole and insula. Inferior parietal and supramarginal gyri were also affected bilaterally in AD as compared to controls. The comparison between DLB and AD evidenced cortical thinning in DLB group in the right posterior regions including superior parietal gyrus, precuneus, cuneus, pericalcarine and lingual gyri. Furthermore, the correlation analysis between cortical thickness and NPI hallucination item scores showed that the structural alteration in the dorsal visual regions including superior parietal gyrus and precuneus closely correlated with the occurrence and severity of VH. We suggest that structural changes in key regions of the dorsal visual network may play a crucial role in the physiopathology of VH in DLB patients.
format	article
author	Stefano Delli Pizzi Raffaella Franciotti Armando Tartaro Massimo Caulo Astrid Thomas Marco Onofrj Laura Bonanni
author_facet	Stefano Delli Pizzi Raffaella Franciotti Armando Tartaro Massimo Caulo Astrid Thomas Marco Onofrj Laura Bonanni
author_sort	Stefano Delli Pizzi
title	Structural alteration of the dorsal visual network in DLB patients with visual hallucinations: a cortical thickness MRI study.
title_short	Structural alteration of the dorsal visual network in DLB patients with visual hallucinations: a cortical thickness MRI study.
title_full	Structural alteration of the dorsal visual network in DLB patients with visual hallucinations: a cortical thickness MRI study.
title_fullStr	Structural alteration of the dorsal visual network in DLB patients with visual hallucinations: a cortical thickness MRI study.
title_full_unstemmed	Structural alteration of the dorsal visual network in DLB patients with visual hallucinations: a cortical thickness MRI study.
title_sort	structural alteration of the dorsal visual network in dlb patients with visual hallucinations: a cortical thickness mri study.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/140bdc0239234aceb73d0e964bf72acb
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Structural alteration of the dorsal visual network in DLB patients with visual hallucinations: a cortical thickness MRI study.

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