Self-Assembly System Based on Cyclodextrin for Targeted Delivery of Cannabidiol

Cannabidiol (CBD) is one specific kind of the cannabinoid in Cannabis sativa L with a wide range of pharmacological activities. However, the poor water solubility and specificity of CBD limits its application in pharmaceutical field. For solving these problems, in this work, we successfully prepared...

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Autores principales:	Panyong Zhu, Pin Lv, Yazhou Zhang, Rongqiang Liao, Jing Liu, Rong Guo, Xuan Chen, Xiali Liao, Chuanzhu Gao, Kun Zhang, Ming Yang, Bo Yang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	biotin ß-cyclodextrin cannabidiol inclusion complex targeting delivery self-assembly Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/140e58a5f7854bc988ebb06f71754dd7
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spelling	oai:doaj.org-article:140e58a5f7854bc988ebb06f71754dd72021-11-08T07:06:43ZSelf-Assembly System Based on Cyclodextrin for Targeted Delivery of Cannabidiol2296-264610.3389/fchem.2021.754832https://doaj.org/article/140e58a5f7854bc988ebb06f71754dd72021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fchem.2021.754832/fullhttps://doaj.org/toc/2296-2646Cannabidiol (CBD) is one specific kind of the cannabinoid in Cannabis sativa L with a wide range of pharmacological activities. However, the poor water solubility and specificity of CBD limits its application in pharmaceutical field. For solving these problems, in this work, we successfully prepared a targeted carrier by grafting biotin (BIO) onto ethylenediamine-β-Cyclodextrin (EN-CD) in a single step to generate a functionalized supramolecule, named BIO-CD. Subsequently, an amantadine-conjugated cannabinoids (AD-CBD) was prepared and self-assembled with the BIO-CD. A series of methods were used to characterize the inclusion behavior and physicochemical properties of AD-CBD and BIO-CD. The results showed that AD-CBD entered the cavity of BIO-CD and formed a 1:1 host-guest inclusion complex. MTT assay and confocal laser scanning microscopy (CLSM) revealed that the targeting effect and anticancer activity of AD-CBD/BIO-CD inclusion complex against three human cancer cell lines were higher than BIO-CD, AD-CBD and free CBD. Moreover, the inclusion complex could release drugs under weakly acidic conditions. These results demonstrated that AD-CBD/BIO-CD inclusion complex possess excellent targeted and anticancer activity, which is hopeful to be applied in clinic as a new therapeutic approach.Panyong ZhuPin LvPin LvYazhou ZhangRongqiang LiaoJing LiuRong GuoXuan ChenXiali LiaoChuanzhu GaoKun ZhangMing YangBo YangFrontiers Media S.A.articlebiotinß-cyclodextrincannabidiolinclusion complextargeting deliveryself-assemblyChemistryQD1-999ENFrontiers in Chemistry, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biotin ß-cyclodextrin cannabidiol inclusion complex targeting delivery self-assembly Chemistry QD1-999
spellingShingle	biotin ß-cyclodextrin cannabidiol inclusion complex targeting delivery self-assembly Chemistry QD1-999 Panyong Zhu Pin Lv Pin Lv Yazhou Zhang Rongqiang Liao Jing Liu Rong Guo Xuan Chen Xiali Liao Chuanzhu Gao Kun Zhang Ming Yang Bo Yang Self-Assembly System Based on Cyclodextrin for Targeted Delivery of Cannabidiol
description	Cannabidiol (CBD) is one specific kind of the cannabinoid in Cannabis sativa L with a wide range of pharmacological activities. However, the poor water solubility and specificity of CBD limits its application in pharmaceutical field. For solving these problems, in this work, we successfully prepared a targeted carrier by grafting biotin (BIO) onto ethylenediamine-β-Cyclodextrin (EN-CD) in a single step to generate a functionalized supramolecule, named BIO-CD. Subsequently, an amantadine-conjugated cannabinoids (AD-CBD) was prepared and self-assembled with the BIO-CD. A series of methods were used to characterize the inclusion behavior and physicochemical properties of AD-CBD and BIO-CD. The results showed that AD-CBD entered the cavity of BIO-CD and formed a 1:1 host-guest inclusion complex. MTT assay and confocal laser scanning microscopy (CLSM) revealed that the targeting effect and anticancer activity of AD-CBD/BIO-CD inclusion complex against three human cancer cell lines were higher than BIO-CD, AD-CBD and free CBD. Moreover, the inclusion complex could release drugs under weakly acidic conditions. These results demonstrated that AD-CBD/BIO-CD inclusion complex possess excellent targeted and anticancer activity, which is hopeful to be applied in clinic as a new therapeutic approach.
format	article
author	Panyong Zhu Pin Lv Pin Lv Yazhou Zhang Rongqiang Liao Jing Liu Rong Guo Xuan Chen Xiali Liao Chuanzhu Gao Kun Zhang Ming Yang Bo Yang
author_facet	Panyong Zhu Pin Lv Pin Lv Yazhou Zhang Rongqiang Liao Jing Liu Rong Guo Xuan Chen Xiali Liao Chuanzhu Gao Kun Zhang Ming Yang Bo Yang
author_sort	Panyong Zhu
title	Self-Assembly System Based on Cyclodextrin for Targeted Delivery of Cannabidiol
title_short	Self-Assembly System Based on Cyclodextrin for Targeted Delivery of Cannabidiol
title_full	Self-Assembly System Based on Cyclodextrin for Targeted Delivery of Cannabidiol
title_fullStr	Self-Assembly System Based on Cyclodextrin for Targeted Delivery of Cannabidiol
title_full_unstemmed	Self-Assembly System Based on Cyclodextrin for Targeted Delivery of Cannabidiol
title_sort	self-assembly system based on cyclodextrin for targeted delivery of cannabidiol
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/140e58a5f7854bc988ebb06f71754dd7
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Self-Assembly System Based on Cyclodextrin for Targeted Delivery of Cannabidiol

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