Androgen inhibits abdominal fat accumulation and negatively regulates the PCK1 gene in male chickens.

Capons are male chickens whose testes have been surgically incised. Capons show a significant increase in fat accumulation compared to intact male chickens. However, while caponization leads to a significant reduction in androgen levels in roosters, little is known about the molecular mechanisms thr...

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Autores principales:	Jinlin Duan, Fan Shao, Yonggang Shao, Junying Li, Yao Ling, Kedao Teng, Hongwei Li, Changxin Wu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/14111b5628bf454dbeb27080376752fc
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spelling	oai:doaj.org-article:14111b5628bf454dbeb27080376752fc2021-11-18T07:51:46ZAndrogen inhibits abdominal fat accumulation and negatively regulates the PCK1 gene in male chickens.1932-620310.1371/journal.pone.0059636https://doaj.org/article/14111b5628bf454dbeb27080376752fc2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23544081/?tool=EBIhttps://doaj.org/toc/1932-6203Capons are male chickens whose testes have been surgically incised. Capons show a significant increase in fat accumulation compared to intact male chickens. However, while caponization leads to a significant reduction in androgen levels in roosters, little is known about the molecular mechanisms through which androgen status affects lipogenesis in avian species. Therefore, investigation of the influence of androgens on fat accumulation in the chicken will provide insights into this process. In this study, Affymetrix microarray technology was used to analyze the gene expression profiles of livers from capons and intact male chickens because the liver is the major site of lipogenesis in avian species. Through gene ontology, we found that genes involved in hepatic lipogenic biosynthesis were the most highly enriched. Interestingly, among the upregulated genes, the cytosolic form of the phosphoenolpyruvate carboxykinase (PCK1) gene showed the greatest fold change. Additionally, in conjunction with quantitative real-time PCR data, our results suggested that androgen status negatively regulated the PCK1 gene in male chickens.Jinlin DuanFan ShaoYonggang ShaoJunying LiYao LingKedao TengHongwei LiChangxin WuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e59636 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jinlin Duan Fan Shao Yonggang Shao Junying Li Yao Ling Kedao Teng Hongwei Li Changxin Wu Androgen inhibits abdominal fat accumulation and negatively regulates the PCK1 gene in male chickens.
description	Capons are male chickens whose testes have been surgically incised. Capons show a significant increase in fat accumulation compared to intact male chickens. However, while caponization leads to a significant reduction in androgen levels in roosters, little is known about the molecular mechanisms through which androgen status affects lipogenesis in avian species. Therefore, investigation of the influence of androgens on fat accumulation in the chicken will provide insights into this process. In this study, Affymetrix microarray technology was used to analyze the gene expression profiles of livers from capons and intact male chickens because the liver is the major site of lipogenesis in avian species. Through gene ontology, we found that genes involved in hepatic lipogenic biosynthesis were the most highly enriched. Interestingly, among the upregulated genes, the cytosolic form of the phosphoenolpyruvate carboxykinase (PCK1) gene showed the greatest fold change. Additionally, in conjunction with quantitative real-time PCR data, our results suggested that androgen status negatively regulated the PCK1 gene in male chickens.
format	article
author	Jinlin Duan Fan Shao Yonggang Shao Junying Li Yao Ling Kedao Teng Hongwei Li Changxin Wu
author_facet	Jinlin Duan Fan Shao Yonggang Shao Junying Li Yao Ling Kedao Teng Hongwei Li Changxin Wu
author_sort	Jinlin Duan
title	Androgen inhibits abdominal fat accumulation and negatively regulates the PCK1 gene in male chickens.
title_short	Androgen inhibits abdominal fat accumulation and negatively regulates the PCK1 gene in male chickens.
title_full	Androgen inhibits abdominal fat accumulation and negatively regulates the PCK1 gene in male chickens.
title_fullStr	Androgen inhibits abdominal fat accumulation and negatively regulates the PCK1 gene in male chickens.
title_full_unstemmed	Androgen inhibits abdominal fat accumulation and negatively regulates the PCK1 gene in male chickens.
title_sort	androgen inhibits abdominal fat accumulation and negatively regulates the pck1 gene in male chickens.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/14111b5628bf454dbeb27080376752fc
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Androgen inhibits abdominal fat accumulation and negatively regulates the PCK1 gene in male chickens.

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