Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance

Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance

Multidrug resistance is a major challenge in cancer therapy. Here, the authors develop a mitochondria-targeting nanoparticle system that inhibits adenosine triphosphate transporter activity via reactive oxygen species generation and can thus be used to target multidrug-resistant cancer.

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Autores principales: Hai Wang, Zan Gao, Xuanyou Liu, Pranay Agarwal, Shuting Zhao, Daniel W. Conroy, Guang Ji, Jianhua Yu, Christopher P. Jaroniec, Zhenguo Liu, Xiongbin Lu, Xiaodong Li, Xiaoming He
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/1411ae0882f24d7aa8a64b2cb0d42b7e
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spelling oai:doaj.org-article:1411ae0882f24d7aa8a64b2cb0d42b7e2021-12-02T15:33:42ZTargeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance10.1038/s41467-018-02915-82041-1723https://doaj.org/article/1411ae0882f24d7aa8a64b2cb0d42b7e2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02915-8https://doaj.org/toc/2041-1723Multidrug resistance is a major challenge in cancer therapy. Here, the authors develop a mitochondria-targeting nanoparticle system that inhibits adenosine triphosphate transporter activity via reactive oxygen species generation and can thus be used to target multidrug-resistant cancer.Hai WangZan GaoXuanyou LiuPranay AgarwalShuting ZhaoDaniel W. ConroyGuang JiJianhua YuChristopher P. JaroniecZhenguo LiuXiongbin LuXiaodong LiXiaoming HeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hai Wang
Zan Gao
Xuanyou Liu
Pranay Agarwal
Shuting Zhao
Daniel W. Conroy
Guang Ji
Jianhua Yu
Christopher P. Jaroniec
Zhenguo Liu
Xiongbin Lu
Xiaodong Li
Xiaoming He
Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance
description Multidrug resistance is a major challenge in cancer therapy. Here, the authors develop a mitochondria-targeting nanoparticle system that inhibits adenosine triphosphate transporter activity via reactive oxygen species generation and can thus be used to target multidrug-resistant cancer.
format article
author Hai Wang
Zan Gao
Xuanyou Liu
Pranay Agarwal
Shuting Zhao
Daniel W. Conroy
Guang Ji
Jianhua Yu
Christopher P. Jaroniec
Zhenguo Liu
Xiongbin Lu
Xiaodong Li
Xiaoming He
author_facet Hai Wang
Zan Gao
Xuanyou Liu
Pranay Agarwal
Shuting Zhao
Daniel W. Conroy
Guang Ji
Jianhua Yu
Christopher P. Jaroniec
Zhenguo Liu
Xiongbin Lu
Xiaodong Li
Xiaoming He
author_sort Hai Wang
title Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance
title_short Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance
title_full Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance
title_fullStr Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance
title_full_unstemmed Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance
title_sort targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/1411ae0882f24d7aa8a64b2cb0d42b7e
work_keys_str_mv AT haiwang targetedproductionofreactiveoxygenspeciesinmitochondriatoovercomecancerdrugresistance
AT zangao targetedproductionofreactiveoxygenspeciesinmitochondriatoovercomecancerdrugresistance
AT xuanyouliu targetedproductionofreactiveoxygenspeciesinmitochondriatoovercomecancerdrugresistance
AT pranayagarwal targetedproductionofreactiveoxygenspeciesinmitochondriatoovercomecancerdrugresistance
AT shutingzhao targetedproductionofreactiveoxygenspeciesinmitochondriatoovercomecancerdrugresistance
AT danielwconroy targetedproductionofreactiveoxygenspeciesinmitochondriatoovercomecancerdrugresistance
AT guangji targetedproductionofreactiveoxygenspeciesinmitochondriatoovercomecancerdrugresistance
AT jianhuayu targetedproductionofreactiveoxygenspeciesinmitochondriatoovercomecancerdrugresistance
AT christopherpjaroniec targetedproductionofreactiveoxygenspeciesinmitochondriatoovercomecancerdrugresistance
AT zhenguoliu targetedproductionofreactiveoxygenspeciesinmitochondriatoovercomecancerdrugresistance
AT xiongbinlu targetedproductionofreactiveoxygenspeciesinmitochondriatoovercomecancerdrugresistance
AT xiaodongli targetedproductionofreactiveoxygenspeciesinmitochondriatoovercomecancerdrugresistance
AT xiaominghe targetedproductionofreactiveoxygenspeciesinmitochondriatoovercomecancerdrugresistance
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