Pediatric COVID-19 patients in South Brazil show abundant viral mRNA and strong specific anti-viral responses

Pediatric COVID-19 patients in South Brazil show abundant viral mRNA and strong specific anti-viral responses

Children often show milder COVID-19 symptoms, but the underlying mechanistic insights are still lacking. Here the authors profile both pediatric and adult cohorts of COVID-19 patients in Brazil to find that children exhibit higher viral load but stronger and biased cellular immunity, thereby serving...

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Main Authors: Tiago Fazolo, Karina Lima, Julia C. Fontoura, Priscila Oliveira de Souza, Gabriel Hilario, Renata Zorzetto, Luiz Rodrigues Júnior, Veridiane Maria Pscheidt, Jayme de Castilhos Ferreira Neto, Alisson F. Haubert, Izza Gambin, Aline C. Oliveira, Raissa S. Mello, Matheus de Bastos Balbe e Gutierres, Rodrigo Benedetti Gassen, Lais Durço Coimbra, Alexandre Borin, Rafael Elias Marques, Ivaine Tais Sauthier Sartor, Gabriela Oliveira Zavaglia, Ingrid Rodrigues Fernandes, Helder I. Nakaya, Fernanda Hammes Varela, Márcia Polese-Bonatto, Thiago J. Borges, Sidia Maria Callegari-Jacques, Marcela Santos Correa da Costa, Jaqueline de Araujo Schwartz, Marcelo Comerlato Scotta, Renato T. Stein, Cristina Bonorino
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Science
Q
Online Access:https://doaj.org/article/1412a6ac909d48a184e0122881fc57b4
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Summary:Children often show milder COVID-19 symptoms, but the underlying mechanistic insights are still lacking. Here the authors profile both pediatric and adult cohorts of COVID-19 patients in Brazil to find that children exhibit higher viral load but stronger and biased cellular immunity, thereby serving clues for the differential responses in children.

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