Pediatric COVID-19 patients in South Brazil show abundant viral mRNA and strong specific anti-viral responses
Children often show milder COVID-19 symptoms, but the underlying mechanistic insights are still lacking. Here the authors profile both pediatric and adult cohorts of COVID-19 patients in Brazil to find that children exhibit higher viral load but stronger and biased cellular immunity, thereby serving...
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Nature Portfolio
2021
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oai:doaj.org-article:1412a6ac909d48a184e0122881fc57b42021-11-28T12:33:17ZPediatric COVID-19 patients in South Brazil show abundant viral mRNA and strong specific anti-viral responses10.1038/s41467-021-27120-y2041-1723https://doaj.org/article/1412a6ac909d48a184e0122881fc57b42021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27120-yhttps://doaj.org/toc/2041-1723Children often show milder COVID-19 symptoms, but the underlying mechanistic insights are still lacking. Here the authors profile both pediatric and adult cohorts of COVID-19 patients in Brazil to find that children exhibit higher viral load but stronger and biased cellular immunity, thereby serving clues for the differential responses in children.Tiago FazoloKarina LimaJulia C. FontouraPriscila Oliveira de SouzaGabriel HilarioRenata ZorzettoLuiz Rodrigues JúniorVeridiane Maria PscheidtJayme de Castilhos Ferreira NetoAlisson F. HaubertIzza GambinAline C. OliveiraRaissa S. MelloMatheus de Bastos Balbe e GutierresRodrigo Benedetti GassenLais Durço CoimbraAlexandre BorinRafael Elias MarquesIvaine Tais Sauthier SartorGabriela Oliveira ZavagliaIngrid Rodrigues FernandesHelder I. NakayaFernanda Hammes VarelaMárcia Polese-BonattoThiago J. BorgesSidia Maria Callegari-JacquesMarcela Santos Correa da CostaJaqueline de Araujo SchwartzMarcelo Comerlato ScottaRenato T. SteinCristina BonorinoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
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Science Q Tiago Fazolo Karina Lima Julia C. Fontoura Priscila Oliveira de Souza Gabriel Hilario Renata Zorzetto Luiz Rodrigues Júnior Veridiane Maria Pscheidt Jayme de Castilhos Ferreira Neto Alisson F. Haubert Izza Gambin Aline C. Oliveira Raissa S. Mello Matheus de Bastos Balbe e Gutierres Rodrigo Benedetti Gassen Lais Durço Coimbra Alexandre Borin Rafael Elias Marques Ivaine Tais Sauthier Sartor Gabriela Oliveira Zavaglia Ingrid Rodrigues Fernandes Helder I. Nakaya Fernanda Hammes Varela Márcia Polese-Bonatto Thiago J. Borges Sidia Maria Callegari-Jacques Marcela Santos Correa da Costa Jaqueline de Araujo Schwartz Marcelo Comerlato Scotta Renato T. Stein Cristina Bonorino Pediatric COVID-19 patients in South Brazil show abundant viral mRNA and strong specific anti-viral responses |
| description |
Children often show milder COVID-19 symptoms, but the underlying mechanistic insights are still lacking. Here the authors profile both pediatric and adult cohorts of COVID-19 patients in Brazil to find that children exhibit higher viral load but stronger and biased cellular immunity, thereby serving clues for the differential responses in children. |
| format |
article |
| author |
Tiago Fazolo Karina Lima Julia C. Fontoura Priscila Oliveira de Souza Gabriel Hilario Renata Zorzetto Luiz Rodrigues Júnior Veridiane Maria Pscheidt Jayme de Castilhos Ferreira Neto Alisson F. Haubert Izza Gambin Aline C. Oliveira Raissa S. Mello Matheus de Bastos Balbe e Gutierres Rodrigo Benedetti Gassen Lais Durço Coimbra Alexandre Borin Rafael Elias Marques Ivaine Tais Sauthier Sartor Gabriela Oliveira Zavaglia Ingrid Rodrigues Fernandes Helder I. Nakaya Fernanda Hammes Varela Márcia Polese-Bonatto Thiago J. Borges Sidia Maria Callegari-Jacques Marcela Santos Correa da Costa Jaqueline de Araujo Schwartz Marcelo Comerlato Scotta Renato T. Stein Cristina Bonorino |
| author_facet |
Tiago Fazolo Karina Lima Julia C. Fontoura Priscila Oliveira de Souza Gabriel Hilario Renata Zorzetto Luiz Rodrigues Júnior Veridiane Maria Pscheidt Jayme de Castilhos Ferreira Neto Alisson F. Haubert Izza Gambin Aline C. Oliveira Raissa S. Mello Matheus de Bastos Balbe e Gutierres Rodrigo Benedetti Gassen Lais Durço Coimbra Alexandre Borin Rafael Elias Marques Ivaine Tais Sauthier Sartor Gabriela Oliveira Zavaglia Ingrid Rodrigues Fernandes Helder I. Nakaya Fernanda Hammes Varela Márcia Polese-Bonatto Thiago J. Borges Sidia Maria Callegari-Jacques Marcela Santos Correa da Costa Jaqueline de Araujo Schwartz Marcelo Comerlato Scotta Renato T. Stein Cristina Bonorino |
| author_sort |
Tiago Fazolo |
| title |
Pediatric COVID-19 patients in South Brazil show abundant viral mRNA and strong specific anti-viral responses |
| title_short |
Pediatric COVID-19 patients in South Brazil show abundant viral mRNA and strong specific anti-viral responses |
| title_full |
Pediatric COVID-19 patients in South Brazil show abundant viral mRNA and strong specific anti-viral responses |
| title_fullStr |
Pediatric COVID-19 patients in South Brazil show abundant viral mRNA and strong specific anti-viral responses |
| title_full_unstemmed |
Pediatric COVID-19 patients in South Brazil show abundant viral mRNA and strong specific anti-viral responses |
| title_sort |
pediatric covid-19 patients in south brazil show abundant viral mrna and strong specific anti-viral responses |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/1412a6ac909d48a184e0122881fc57b4 |
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