Expression of type III collagen in hypertrophic gingival tissue of patients with orthodontic treatment: a pilot study

Introduction: gingival hypertrophy (GH) is the uncontrolled increase in gingival volume induced by different etiological factors, including orthodontic treatment. This pathology is characterized by changes in epithelial and connective tissue, including modifications in the extracellular matrix. The...

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Autores principales:	Víctor Hugo Simancas-Escorcia, Jocsan Steven Leal-Betancur, Antonio Díaz-Caballero
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2020
Materias:	gingival hypertrophy collagen immunohistochemistry orthodontics type iii collagen Dentistry RK1-715
Acceso en línea:	https://doaj.org/article/1413d8dfb9b04c99aa288d2cc8d9c00e
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spelling	oai:doaj.org-article:1413d8dfb9b04c99aa288d2cc8d9c00e2021-11-27T16:27:35ZExpression of type III collagen in hypertrophic gingival tissue of patients with orthodontic treatment: a pilot study2145-767010.17533/udea.rfo.v32n2a5https://doaj.org/article/1413d8dfb9b04c99aa288d2cc8d9c00e2020-10-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/odont/article/view/342645https://doaj.org/toc/2145-7670Introduction: gingival hypertrophy (GH) is the uncontrolled increase in gingival volume induced by different etiological factors, including orthodontic treatment. This pathology is characterized by changes in epithelial and connective tissue, including modifications in the extracellular matrix. The present study determined the presence and distribution of type III collagen in tissues of patients with GH wearing fixed orthodontic appliances. Methods: 12 samples of gingival tissue were obtained from patients undergoing periodontal surgery. They were divided into two groups, the first with healthy patients (control; n = 6) and the second with patients diagnosed with GH and orthodontic treatment (patients; n = 6). Each obtained sample was subjected to the hematoxylin-eosin stain, Masson-Goldner staining, and type III collagen immunohistochemistry. Results: the hematoxylin-eosin and Masson-Goldner histological stains showed hypertrophia of epithelial tissue and connective tissue with a marked collagen fiber increase in the gingival tissue of orthodontic wearers with GH compared to individuals in the control group. The gingival tissue of patients with GH caused by orthodontic treatment showed a distribution and location of type III collagen near the basal lamina, around the blood vessels, but unlike the control group, its location was noticeable throughout the connective tissue. Conclusion: the gingival tissues of orthodontic wearers with GH experience an increase in the number and density of collagen fibers. Type III collagen seems to lose its usual location in the gingival tissues of orthodontic wearers with GH.Víctor Hugo Simancas-EscorciaJocsan Steven Leal-BetancurAntonio Díaz-CaballeroUniversidad de Antioquiaarticlegingival hypertrophycollagenimmunohistochemistryorthodonticstype iii collagenDentistryRK1-715ENRevista Facultad de Odontología Universidad de Antioquia, Vol 32, Iss 2, Pp 53-63 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	gingival hypertrophy collagen immunohistochemistry orthodontics type iii collagen Dentistry RK1-715
spellingShingle	gingival hypertrophy collagen immunohistochemistry orthodontics type iii collagen Dentistry RK1-715 Víctor Hugo Simancas-Escorcia Jocsan Steven Leal-Betancur Antonio Díaz-Caballero Expression of type III collagen in hypertrophic gingival tissue of patients with orthodontic treatment: a pilot study
description	Introduction: gingival hypertrophy (GH) is the uncontrolled increase in gingival volume induced by different etiological factors, including orthodontic treatment. This pathology is characterized by changes in epithelial and connective tissue, including modifications in the extracellular matrix. The present study determined the presence and distribution of type III collagen in tissues of patients with GH wearing fixed orthodontic appliances. Methods: 12 samples of gingival tissue were obtained from patients undergoing periodontal surgery. They were divided into two groups, the first with healthy patients (control; n = 6) and the second with patients diagnosed with GH and orthodontic treatment (patients; n = 6). Each obtained sample was subjected to the hematoxylin-eosin stain, Masson-Goldner staining, and type III collagen immunohistochemistry. Results: the hematoxylin-eosin and Masson-Goldner histological stains showed hypertrophia of epithelial tissue and connective tissue with a marked collagen fiber increase in the gingival tissue of orthodontic wearers with GH compared to individuals in the control group. The gingival tissue of patients with GH caused by orthodontic treatment showed a distribution and location of type III collagen near the basal lamina, around the blood vessels, but unlike the control group, its location was noticeable throughout the connective tissue. Conclusion: the gingival tissues of orthodontic wearers with GH experience an increase in the number and density of collagen fibers. Type III collagen seems to lose its usual location in the gingival tissues of orthodontic wearers with GH.
format	article
author	Víctor Hugo Simancas-Escorcia Jocsan Steven Leal-Betancur Antonio Díaz-Caballero
author_facet	Víctor Hugo Simancas-Escorcia Jocsan Steven Leal-Betancur Antonio Díaz-Caballero
author_sort	Víctor Hugo Simancas-Escorcia
title	Expression of type III collagen in hypertrophic gingival tissue of patients with orthodontic treatment: a pilot study
title_short	Expression of type III collagen in hypertrophic gingival tissue of patients with orthodontic treatment: a pilot study
title_full	Expression of type III collagen in hypertrophic gingival tissue of patients with orthodontic treatment: a pilot study
title_fullStr	Expression of type III collagen in hypertrophic gingival tissue of patients with orthodontic treatment: a pilot study
title_full_unstemmed	Expression of type III collagen in hypertrophic gingival tissue of patients with orthodontic treatment: a pilot study
title_sort	expression of type iii collagen in hypertrophic gingival tissue of patients with orthodontic treatment: a pilot study
publisher	Universidad de Antioquia
publishDate	2020
url	https://doaj.org/article/1413d8dfb9b04c99aa288d2cc8d9c00e
work_keys_str_mv	AT victorhugosimancasescorcia expressionoftypeiiicollageninhypertrophicgingivaltissueofpatientswithorthodontictreatmentapilotstudy AT jocsanstevenlealbetancur expressionoftypeiiicollageninhypertrophicgingivaltissueofpatientswithorthodontictreatmentapilotstudy AT antoniodiazcaballero expressionoftypeiiicollageninhypertrophicgingivaltissueofpatientswithorthodontictreatmentapilotstudy
_version_	1718408422074875904

Expression of type III collagen in hypertrophic gingival tissue of patients with orthodontic treatment: a pilot study

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