Ultraviolet radiation protection potentials of Methylene Blue for human skin and coral reef health

Abstract Methylene blue (MB) is a century-old medicine, a laboratory dye, and recently shown as a premier antioxidant that combats ROS-induced cellular aging in human skins. Given MB’s molecular structure and light absorption properties, we hypothesize that MB has the potential to be considered as a...

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Autores principales:	Zheng-Mei Xiong, Xiaojing Mao, Mason Trappio, Chanda Arya, Jasmin el Kordi, Kan Cao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1413f1dd95c34da8bac22324d41508fd
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spelling	oai:doaj.org-article:1413f1dd95c34da8bac22324d41508fd2021-12-02T15:00:55ZUltraviolet radiation protection potentials of Methylene Blue for human skin and coral reef health10.1038/s41598-021-89970-22045-2322https://doaj.org/article/1413f1dd95c34da8bac22324d41508fd2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89970-2https://doaj.org/toc/2045-2322Abstract Methylene blue (MB) is a century-old medicine, a laboratory dye, and recently shown as a premier antioxidant that combats ROS-induced cellular aging in human skins. Given MB’s molecular structure and light absorption properties, we hypothesize that MB has the potential to be considered as a sunscreen active for UV radiation protection. In this study, we tested the effects of MB on UVB ray-induced DNA double-strand breaks in primary human keratinocytes. We found that MB treatment reduced DNA damages caused by UVB irradiation and subsequent cell death. Next, we compared MB with Oxybenzone, which is the most commonly used chemical active ingredient in sunscreens but recently proven to be hazardous to aquatic ecosystems, in particular to coral reefs. At the same concentrations, MB showed more effective UVB absorption ability than Oxybenzone and significantly outperformed Oxybenzone in the prevention of UVB-induced DNA damage and the clearance of UVA-induced cellular ROS. Furthermore, unlike Oxybenzone, MB-containing seawater did not affect the growth of the coral species Xenia umbellata. Altogether, our study suggests that MB has the potential to be a coral reef-friendly sunscreen active ingredient that can provide broad-spectrum protection against UVA and UVB.Zheng-Mei XiongXiaojing MaoMason TrappioChanda AryaJasmin el KordiKan CaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zheng-Mei Xiong Xiaojing Mao Mason Trappio Chanda Arya Jasmin el Kordi Kan Cao Ultraviolet radiation protection potentials of Methylene Blue for human skin and coral reef health
description	Abstract Methylene blue (MB) is a century-old medicine, a laboratory dye, and recently shown as a premier antioxidant that combats ROS-induced cellular aging in human skins. Given MB’s molecular structure and light absorption properties, we hypothesize that MB has the potential to be considered as a sunscreen active for UV radiation protection. In this study, we tested the effects of MB on UVB ray-induced DNA double-strand breaks in primary human keratinocytes. We found that MB treatment reduced DNA damages caused by UVB irradiation and subsequent cell death. Next, we compared MB with Oxybenzone, which is the most commonly used chemical active ingredient in sunscreens but recently proven to be hazardous to aquatic ecosystems, in particular to coral reefs. At the same concentrations, MB showed more effective UVB absorption ability than Oxybenzone and significantly outperformed Oxybenzone in the prevention of UVB-induced DNA damage and the clearance of UVA-induced cellular ROS. Furthermore, unlike Oxybenzone, MB-containing seawater did not affect the growth of the coral species Xenia umbellata. Altogether, our study suggests that MB has the potential to be a coral reef-friendly sunscreen active ingredient that can provide broad-spectrum protection against UVA and UVB.
format	article
author	Zheng-Mei Xiong Xiaojing Mao Mason Trappio Chanda Arya Jasmin el Kordi Kan Cao
author_facet	Zheng-Mei Xiong Xiaojing Mao Mason Trappio Chanda Arya Jasmin el Kordi Kan Cao
author_sort	Zheng-Mei Xiong
title	Ultraviolet radiation protection potentials of Methylene Blue for human skin and coral reef health
title_short	Ultraviolet radiation protection potentials of Methylene Blue for human skin and coral reef health
title_full	Ultraviolet radiation protection potentials of Methylene Blue for human skin and coral reef health
title_fullStr	Ultraviolet radiation protection potentials of Methylene Blue for human skin and coral reef health
title_full_unstemmed	Ultraviolet radiation protection potentials of Methylene Blue for human skin and coral reef health
title_sort	ultraviolet radiation protection potentials of methylene blue for human skin and coral reef health
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1413f1dd95c34da8bac22324d41508fd
work_keys_str_mv	AT zhengmeixiong ultravioletradiationprotectionpotentialsofmethyleneblueforhumanskinandcoralreefhealth AT xiaojingmao ultravioletradiationprotectionpotentialsofmethyleneblueforhumanskinandcoralreefhealth AT masontrappio ultravioletradiationprotectionpotentialsofmethyleneblueforhumanskinandcoralreefhealth AT chandaarya ultravioletradiationprotectionpotentialsofmethyleneblueforhumanskinandcoralreefhealth AT jasminelkordi ultravioletradiationprotectionpotentialsofmethyleneblueforhumanskinandcoralreefhealth AT kancao ultravioletradiationprotectionpotentialsofmethyleneblueforhumanskinandcoralreefhealth
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Ultraviolet radiation protection potentials of Methylene Blue for human skin and coral reef health

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