Boosting NAD+ with a small molecule that activates NAMPT

Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate determining step for NAD+ synthesis and is of interest as a drug target. Here the authors identify and characterize a small molecule NAMPT activator SBI-797812, elucidate its mode of action and show that it increases intracellular NMN...

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Autores principales:	Stephen J. Gardell, Meghan Hopf, Asima Khan, Mauro Dispagna, E. Hampton Sessions, Rebecca Falter, Nidhi Kapoor, Jeanne Brooks, Jeffrey Culver, Chris Petucci, Chen-Ting Ma, Steven E. Cohen, Jun Tanaka, Emmanuel S. Burgos, Jennifer S. Hirschi, Steven R. Smith, Eduard Sergienko, Anthony B. Pinkerton
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1414d8924adf4074afe7c8dc6bbcf1cf
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spelling	oai:doaj.org-article:1414d8924adf4074afe7c8dc6bbcf1cf2021-12-02T14:38:42ZBoosting NAD+ with a small molecule that activates NAMPT10.1038/s41467-019-11078-z2041-1723https://doaj.org/article/1414d8924adf4074afe7c8dc6bbcf1cf2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11078-zhttps://doaj.org/toc/2041-1723Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate determining step for NAD+ synthesis and is of interest as a drug target. Here the authors identify and characterize a small molecule NAMPT activator SBI-797812, elucidate its mode of action and show that it increases intracellular NMN and NAD+ levels in cultured cells and elevates liver NAD+ in mice.Stephen J. GardellMeghan HopfAsima KhanMauro DispagnaE. Hampton SessionsRebecca FalterNidhi KapoorJeanne BrooksJeffrey CulverChris PetucciChen-Ting MaSteven E. CohenJun TanakaEmmanuel S. BurgosJennifer S. HirschiSteven R. SmithEduard SergienkoAnthony B. PinkertonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stephen J. Gardell Meghan Hopf Asima Khan Mauro Dispagna E. Hampton Sessions Rebecca Falter Nidhi Kapoor Jeanne Brooks Jeffrey Culver Chris Petucci Chen-Ting Ma Steven E. Cohen Jun Tanaka Emmanuel S. Burgos Jennifer S. Hirschi Steven R. Smith Eduard Sergienko Anthony B. Pinkerton Boosting NAD+ with a small molecule that activates NAMPT
description	Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate determining step for NAD+ synthesis and is of interest as a drug target. Here the authors identify and characterize a small molecule NAMPT activator SBI-797812, elucidate its mode of action and show that it increases intracellular NMN and NAD+ levels in cultured cells and elevates liver NAD+ in mice.
format	article
author	Stephen J. Gardell Meghan Hopf Asima Khan Mauro Dispagna E. Hampton Sessions Rebecca Falter Nidhi Kapoor Jeanne Brooks Jeffrey Culver Chris Petucci Chen-Ting Ma Steven E. Cohen Jun Tanaka Emmanuel S. Burgos Jennifer S. Hirschi Steven R. Smith Eduard Sergienko Anthony B. Pinkerton
author_facet	Stephen J. Gardell Meghan Hopf Asima Khan Mauro Dispagna E. Hampton Sessions Rebecca Falter Nidhi Kapoor Jeanne Brooks Jeffrey Culver Chris Petucci Chen-Ting Ma Steven E. Cohen Jun Tanaka Emmanuel S. Burgos Jennifer S. Hirschi Steven R. Smith Eduard Sergienko Anthony B. Pinkerton
author_sort	Stephen J. Gardell
title	Boosting NAD+ with a small molecule that activates NAMPT
title_short	Boosting NAD+ with a small molecule that activates NAMPT
title_full	Boosting NAD+ with a small molecule that activates NAMPT
title_fullStr	Boosting NAD+ with a small molecule that activates NAMPT
title_full_unstemmed	Boosting NAD+ with a small molecule that activates NAMPT
title_sort	boosting nad+ with a small molecule that activates nampt
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/1414d8924adf4074afe7c8dc6bbcf1cf
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Boosting NAD+ with a small molecule that activates NAMPT

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