Single-cell transcriptional networks in differentiating preadipocytes suggest drivers associated with tissue heterogeneity

The origin of the heterogeneity of metabolic and inflammatory profiles exhibited by white adipocytes is little understood. Here, using scRNA-seq and computational methods, the authors show that differentiating preadipocytes exhibit gene expression differences and suggest underlying regulators.

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Autores principales:	Alfred K. Ramirez, Simon N. Dankel, Bashir Rastegarpanah, Weikang Cai, Ruidan Xue, Mark Crovella, Yu-Hua Tseng, C. Ronald Kahn, Simon Kasif
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1416263bed5c488e805d2dbdb75df926
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spelling	oai:doaj.org-article:1416263bed5c488e805d2dbdb75df9262021-12-02T14:40:41ZSingle-cell transcriptional networks in differentiating preadipocytes suggest drivers associated with tissue heterogeneity10.1038/s41467-020-16019-92041-1723https://doaj.org/article/1416263bed5c488e805d2dbdb75df9262020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16019-9https://doaj.org/toc/2041-1723The origin of the heterogeneity of metabolic and inflammatory profiles exhibited by white adipocytes is little understood. Here, using scRNA-seq and computational methods, the authors show that differentiating preadipocytes exhibit gene expression differences and suggest underlying regulators.Alfred K. RamirezSimon N. DankelBashir RastegarpanahWeikang CaiRuidan XueMark CrovellaYu-Hua TsengC. Ronald KahnSimon KasifNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alfred K. Ramirez Simon N. Dankel Bashir Rastegarpanah Weikang Cai Ruidan Xue Mark Crovella Yu-Hua Tseng C. Ronald Kahn Simon Kasif Single-cell transcriptional networks in differentiating preadipocytes suggest drivers associated with tissue heterogeneity
description	The origin of the heterogeneity of metabolic and inflammatory profiles exhibited by white adipocytes is little understood. Here, using scRNA-seq and computational methods, the authors show that differentiating preadipocytes exhibit gene expression differences and suggest underlying regulators.
format	article
author	Alfred K. Ramirez Simon N. Dankel Bashir Rastegarpanah Weikang Cai Ruidan Xue Mark Crovella Yu-Hua Tseng C. Ronald Kahn Simon Kasif
author_facet	Alfred K. Ramirez Simon N. Dankel Bashir Rastegarpanah Weikang Cai Ruidan Xue Mark Crovella Yu-Hua Tseng C. Ronald Kahn Simon Kasif
author_sort	Alfred K. Ramirez
title	Single-cell transcriptional networks in differentiating preadipocytes suggest drivers associated with tissue heterogeneity
title_short	Single-cell transcriptional networks in differentiating preadipocytes suggest drivers associated with tissue heterogeneity
title_full	Single-cell transcriptional networks in differentiating preadipocytes suggest drivers associated with tissue heterogeneity
title_fullStr	Single-cell transcriptional networks in differentiating preadipocytes suggest drivers associated with tissue heterogeneity
title_full_unstemmed	Single-cell transcriptional networks in differentiating preadipocytes suggest drivers associated with tissue heterogeneity
title_sort	single-cell transcriptional networks in differentiating preadipocytes suggest drivers associated with tissue heterogeneity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1416263bed5c488e805d2dbdb75df926
work_keys_str_mv	AT alfredkramirez singlecelltranscriptionalnetworksindifferentiatingpreadipocytessuggestdriversassociatedwithtissueheterogeneity AT simonndankel singlecelltranscriptionalnetworksindifferentiatingpreadipocytessuggestdriversassociatedwithtissueheterogeneity AT bashirrastegarpanah singlecelltranscriptionalnetworksindifferentiatingpreadipocytessuggestdriversassociatedwithtissueheterogeneity AT weikangcai singlecelltranscriptionalnetworksindifferentiatingpreadipocytessuggestdriversassociatedwithtissueheterogeneity AT ruidanxue singlecelltranscriptionalnetworksindifferentiatingpreadipocytessuggestdriversassociatedwithtissueheterogeneity AT markcrovella singlecelltranscriptionalnetworksindifferentiatingpreadipocytessuggestdriversassociatedwithtissueheterogeneity AT yuhuatseng singlecelltranscriptionalnetworksindifferentiatingpreadipocytessuggestdriversassociatedwithtissueheterogeneity AT cronaldkahn singlecelltranscriptionalnetworksindifferentiatingpreadipocytessuggestdriversassociatedwithtissueheterogeneity AT simonkasif singlecelltranscriptionalnetworksindifferentiatingpreadipocytessuggestdriversassociatedwithtissueheterogeneity
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Single-cell transcriptional networks in differentiating preadipocytes suggest drivers associated with tissue heterogeneity

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