Acute Flaccid Myelitis: Something Old and Something New

ABSTRACT Since 2014, acute flaccid myelitis (AFM), a long-recognized condition associated with polioviruses, nonpolio enteroviruses, and various other viral and nonviral causes, has been reemerging globally in epidemic form. This unanticipated reemergence is ironic, given that polioviruses, once the...

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Autores principales:	David M. Morens, Gregory K. Folkers, Anthony S. Fauci
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	acute flaccid myelitis emerging diseases enterovirus neurology Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/14177fe2e1934b5cb3db2a9bb569bd9b
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spelling	oai:doaj.org-article:14177fe2e1934b5cb3db2a9bb569bd9b2021-11-15T15:55:26ZAcute Flaccid Myelitis: Something Old and Something New10.1128/mBio.00521-192150-7511https://doaj.org/article/14177fe2e1934b5cb3db2a9bb569bd9b2019-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00521-19https://doaj.org/toc/2150-7511ABSTRACT Since 2014, acute flaccid myelitis (AFM), a long-recognized condition associated with polioviruses, nonpolio enteroviruses, and various other viral and nonviral causes, has been reemerging globally in epidemic form. This unanticipated reemergence is ironic, given that polioviruses, once the major causes of AFM, are now at the very threshold of global eradication and cannot therefore explain any aspect of AFM reemergence. Instead, the new AFM epidemic has been temporally associated with reemergences of nonpolio enteroviruses such as EV-D68, until recently thought to be an obscure virus of extremely low endemicity. This perspective reviews the enigmatic epidemiologic, virologic, and diagnostic aspects of epidemic AFM reemergence; examines current options for clinical management; discusses future research needs; and suggests that the AFM epidemic offers important clues to mechanisms of viral disease emergence.David M. MorensGregory K. FolkersAnthony S. FauciAmerican Society for Microbiologyarticleacute flaccid myelitisemerging diseasesenterovirusneurologyMicrobiologyQR1-502ENmBio, Vol 10, Iss 2 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	acute flaccid myelitis emerging diseases enterovirus neurology Microbiology QR1-502
spellingShingle	acute flaccid myelitis emerging diseases enterovirus neurology Microbiology QR1-502 David M. Morens Gregory K. Folkers Anthony S. Fauci Acute Flaccid Myelitis: Something Old and Something New
description	ABSTRACT Since 2014, acute flaccid myelitis (AFM), a long-recognized condition associated with polioviruses, nonpolio enteroviruses, and various other viral and nonviral causes, has been reemerging globally in epidemic form. This unanticipated reemergence is ironic, given that polioviruses, once the major causes of AFM, are now at the very threshold of global eradication and cannot therefore explain any aspect of AFM reemergence. Instead, the new AFM epidemic has been temporally associated with reemergences of nonpolio enteroviruses such as EV-D68, until recently thought to be an obscure virus of extremely low endemicity. This perspective reviews the enigmatic epidemiologic, virologic, and diagnostic aspects of epidemic AFM reemergence; examines current options for clinical management; discusses future research needs; and suggests that the AFM epidemic offers important clues to mechanisms of viral disease emergence.
format	article
author	David M. Morens Gregory K. Folkers Anthony S. Fauci
author_facet	David M. Morens Gregory K. Folkers Anthony S. Fauci
author_sort	David M. Morens
title	Acute Flaccid Myelitis: Something Old and Something New
title_short	Acute Flaccid Myelitis: Something Old and Something New
title_full	Acute Flaccid Myelitis: Something Old and Something New
title_fullStr	Acute Flaccid Myelitis: Something Old and Something New
title_full_unstemmed	Acute Flaccid Myelitis: Something Old and Something New
title_sort	acute flaccid myelitis: something old and something new
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/14177fe2e1934b5cb3db2a9bb569bd9b
work_keys_str_mv	AT davidmmorens acuteflaccidmyelitissomethingoldandsomethingnew AT gregorykfolkers acuteflaccidmyelitissomethingoldandsomethingnew AT anthonysfauci acuteflaccidmyelitissomethingoldandsomethingnew
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Acute Flaccid Myelitis: Something Old and Something New

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