Radiotherapy-Induced Digestive Injury: Diagnosis, Treatment and Mechanisms

Radiotherapy is one of the main therapeutic methods for treating cancer. The digestive system consists of the gastrointestinal tract and the accessory organs of digestion (the tongue, salivary glands, pancreas, liver and gallbladder). The digestive system is easily impaired during radiotherapy, espe...

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Autores principales:	Guangxia Chen, Yi Han, Haihan Zhang, Wenling Tu, Shuyu Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	ionizing radiation radiation-induced digestive injury gut microbiota gland transfer apoptosis ferroptosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/141c4097bb9f42718ed9cedc13e851b7
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spelling	oai:doaj.org-article:141c4097bb9f42718ed9cedc13e851b72021-11-05T09:27:13ZRadiotherapy-Induced Digestive Injury: Diagnosis, Treatment and Mechanisms2234-943X10.3389/fonc.2021.757973https://doaj.org/article/141c4097bb9f42718ed9cedc13e851b72021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.757973/fullhttps://doaj.org/toc/2234-943XRadiotherapy is one of the main therapeutic methods for treating cancer. The digestive system consists of the gastrointestinal tract and the accessory organs of digestion (the tongue, salivary glands, pancreas, liver and gallbladder). The digestive system is easily impaired during radiotherapy, especially in thoracic and abdominal radiotherapy. In this review, we introduce the physical classification, basic pathogenesis, clinical characteristics, predictive/diagnostic factors, and possible treatment targets of radiotherapy-induced digestive injury. Radiotherapy-induced digestive injury complies with the dose-volume effect and has a radiation-based organ correlation. Computed tomography (CT), MRI (magnetic resonance imaging), ultrasound (US) and endoscopy can help diagnose and evaluate the radiation-induced lesion level. The latest treatment approaches include improvement in radiotherapy (such as shielding, hydrogel spacers and dose distribution), stem cell transplantation and drug administration. Gut microbiota modulation may become a novel approach to relieving radiogenic gastrointestinal syndrome. Finally, we summarized the possible mechanisms involved in treatment, but they remain varied. Radionuclide-labeled targeting molecules (RLTMs) are promising for more precise radiotherapy. These advances contribute to our understanding of the assessment and treatment of radiation-induced digestive injury.Guangxia ChenYi HanHaihan ZhangWenling TuShuyu ZhangShuyu ZhangFrontiers Media S.A.articleionizing radiationradiation-induced digestive injurygut microbiotagland transferapoptosisferroptosisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ionizing radiation radiation-induced digestive injury gut microbiota gland transfer apoptosis ferroptosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	ionizing radiation radiation-induced digestive injury gut microbiota gland transfer apoptosis ferroptosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Guangxia Chen Yi Han Haihan Zhang Wenling Tu Shuyu Zhang Shuyu Zhang Radiotherapy-Induced Digestive Injury: Diagnosis, Treatment and Mechanisms
description	Radiotherapy is one of the main therapeutic methods for treating cancer. The digestive system consists of the gastrointestinal tract and the accessory organs of digestion (the tongue, salivary glands, pancreas, liver and gallbladder). The digestive system is easily impaired during radiotherapy, especially in thoracic and abdominal radiotherapy. In this review, we introduce the physical classification, basic pathogenesis, clinical characteristics, predictive/diagnostic factors, and possible treatment targets of radiotherapy-induced digestive injury. Radiotherapy-induced digestive injury complies with the dose-volume effect and has a radiation-based organ correlation. Computed tomography (CT), MRI (magnetic resonance imaging), ultrasound (US) and endoscopy can help diagnose and evaluate the radiation-induced lesion level. The latest treatment approaches include improvement in radiotherapy (such as shielding, hydrogel spacers and dose distribution), stem cell transplantation and drug administration. Gut microbiota modulation may become a novel approach to relieving radiogenic gastrointestinal syndrome. Finally, we summarized the possible mechanisms involved in treatment, but they remain varied. Radionuclide-labeled targeting molecules (RLTMs) are promising for more precise radiotherapy. These advances contribute to our understanding of the assessment and treatment of radiation-induced digestive injury.
format	article
author	Guangxia Chen Yi Han Haihan Zhang Wenling Tu Shuyu Zhang Shuyu Zhang
author_facet	Guangxia Chen Yi Han Haihan Zhang Wenling Tu Shuyu Zhang Shuyu Zhang
author_sort	Guangxia Chen
title	Radiotherapy-Induced Digestive Injury: Diagnosis, Treatment and Mechanisms
title_short	Radiotherapy-Induced Digestive Injury: Diagnosis, Treatment and Mechanisms
title_full	Radiotherapy-Induced Digestive Injury: Diagnosis, Treatment and Mechanisms
title_fullStr	Radiotherapy-Induced Digestive Injury: Diagnosis, Treatment and Mechanisms
title_full_unstemmed	Radiotherapy-Induced Digestive Injury: Diagnosis, Treatment and Mechanisms
title_sort	radiotherapy-induced digestive injury: diagnosis, treatment and mechanisms
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/141c4097bb9f42718ed9cedc13e851b7
work_keys_str_mv	AT guangxiachen radiotherapyinduceddigestiveinjurydiagnosistreatmentandmechanisms AT yihan radiotherapyinduceddigestiveinjurydiagnosistreatmentandmechanisms AT haihanzhang radiotherapyinduceddigestiveinjurydiagnosistreatmentandmechanisms AT wenlingtu radiotherapyinduceddigestiveinjurydiagnosistreatmentandmechanisms AT shuyuzhang radiotherapyinduceddigestiveinjurydiagnosistreatmentandmechanisms AT shuyuzhang radiotherapyinduceddigestiveinjurydiagnosistreatmentandmechanisms
_version_	1718444331370545152

Radiotherapy-Induced Digestive Injury: Diagnosis, Treatment and Mechanisms

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