LW1497, an Inhibitor of Malate Dehydrogenase, Suppresses TGF-β1-Induced Epithelial-Mesenchymal Transition in Lung Cancer Cells by Downregulating Slug

LW1497, an Inhibitor of Malate Dehydrogenase, Suppresses TGF-β1-Induced Epithelial-Mesenchymal Transition in Lung Cancer Cells by Downregulating Slug

LW1497 suppresses the expression of the hypoxia-inducing factor (HIF)-1α inhibiting malate dehydrogenase. Although hypoxia and HIF-1α are known to be important in cancer, LW1497 has not been therapeutically applied to cancer yet. Thus, we investigated the effect of LW1497 on the epithelial-mesenchym...

Full description

Saved in:
Bibliographic Details
Main Authors: Hyun Ji Kim, Mi Kyung Park, Hyun Jung Byun, Minkyoung Kim, Boram Kim, Lu Yu, Tuan Minh Nguyen, Thi Ha Nguyen, Phuong Anh Do, Eun Ji Kim, Ji Hyun Kim, Enkhmend Enkhtaivan, Kyung Sung Kim, Ji Yun Jang, Gyeoung Jin Kang, Ho Lee, Misun Won, Kyeong Lee, Jungsook Cho, Chang Hoon Lee
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
malate dehydrogenase
epithelial-mesenchymal transition
hypoxia inducible factor-α1
slug
A549
local oxygen tension
Therapeutics. Pharmacology
RM1-950
Online Access:https://doaj.org/article/141c8b24db014edda9b8f8ddc25a88ea
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/141c8b24db014edda9b8f8ddc25a88ea

Similar Items