LW1497, an Inhibitor of Malate Dehydrogenase, Suppresses TGF-β1-Induced Epithelial-Mesenchymal Transition in Lung Cancer Cells by Downregulating Slug

LW1497, an Inhibitor of Malate Dehydrogenase, Suppresses TGF-β1-Induced Epithelial-Mesenchymal Transition in Lung Cancer Cells by Downregulating Slug

LW1497 suppresses the expression of the hypoxia-inducing factor (HIF)-1α inhibiting malate dehydrogenase. Although hypoxia and HIF-1α are known to be important in cancer, LW1497 has not been therapeutically applied to cancer yet. Thus, we investigated the effect of LW1497 on the epithelial-mesenchym...

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Auteurs principaux: Hyun Ji Kim, Mi Kyung Park, Hyun Jung Byun, Minkyoung Kim, Boram Kim, Lu Yu, Tuan Minh Nguyen, Thi Ha Nguyen, Phuong Anh Do, Eun Ji Kim, Ji Hyun Kim, Enkhmend Enkhtaivan, Kyung Sung Kim, Ji Yun Jang, Gyeoung Jin Kang, Ho Lee, Misun Won, Kyeong Lee, Jungsook Cho, Chang Hoon Lee
Format: article
Langue:EN
Publié: MDPI AG 2021
Sujets:
malate dehydrogenase
epithelial-mesenchymal transition
hypoxia inducible factor-α1
slug
A549
local oxygen tension
Therapeutics. Pharmacology
RM1-950
Accès en ligne:https://doaj.org/article/141c8b24db014edda9b8f8ddc25a88ea
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https://doaj.org/article/141c8b24db014edda9b8f8ddc25a88ea

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