EFFECT OF FORMALDEHYDE ON INTERSTITIAL TISSUE OF SEMINIFEROUS TUBULES IN TESTIS OF BALB/C MICE

BACKGROUND AND OBJECTIVE: Formaldehyde is one of agents with absorbable potential which can use in industry and also in many productions such as technical, pharmaceutical and sanitary compounds. Previous study shown that formaldehyde can affect on testicular tissue and reduce spermatogenesis phenome...

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Autor principal:	M.R. Nikravesh, M. Jalali, A.R. Fazel
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2009
Materias:	formaldehyde immunohistochemistry testis interstitial tissue mouse Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/141f65eb3e484c9193bfa6cff601523d
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spelling	oai:doaj.org-article:141f65eb3e484c9193bfa6cff601523d2021-11-10T09:02:27ZEFFECT OF FORMALDEHYDE ON INTERSTITIAL TISSUE OF SEMINIFEROUS TUBULES IN TESTIS OF BALB/C MICE1561-41072251-7170https://doaj.org/article/141f65eb3e484c9193bfa6cff601523d2009-01-01T00:00:00Zhttp://jbums.org/article-1-3109-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Formaldehyde is one of agents with absorbable potential which can use in industry and also in many productions such as technical, pharmaceutical and sanitary compounds. Previous study shown that formaldehyde can affect on testicular tissue and reduce spermatogenesis phenomena. This study was carried out to determine the effects of formaldehyde on leydig cells and testicular vasculogenesis.METHODS: Twenty mature male Balb/c mice were randomly divided into experimental and control groups (n=10). Experimental group were administered 0.25 mg/kg body weight dissolved formaldehyde intraperitoneally for 10 days. The control groups were received the same volume of normal saline during the same period of times. At the end of exposure time, animals were scarified and their testes were removed for processing, serially sectioned and immunohistochemistry by using PCNA method were carried out.FINDINGS: The finding revealed that the numerical density of leydig cells decreased significantly in experimental group in contrast controls (42 versus 66 per/m3 respectively). In addition, a number of shrinkage and picnotic leydig cells indicated occurrence of chromatolysis phenomena in experimental group.CONCLUSION: These data reveal that administration of formaldehyde may result in significant structural changes in male reproductive system such as interstitial tissue of seminiferous tubules and cell death among leydig cells population.M.R. Nikravesh, M. Jalali, A.R. FazelBabol University of Medical Sciencesarticleformaldehydeimmunohistochemistrytestis interstitial tissuemouseMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 10, Iss 6, Pp 23-30 (2009)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	formaldehyde immunohistochemistry testis interstitial tissue mouse Medicine R Medicine (General) R5-920
spellingShingle	formaldehyde immunohistochemistry testis interstitial tissue mouse Medicine R Medicine (General) R5-920 M.R. Nikravesh, M. Jalali, A.R. Fazel EFFECT OF FORMALDEHYDE ON INTERSTITIAL TISSUE OF SEMINIFEROUS TUBULES IN TESTIS OF BALB/C MICE
description	BACKGROUND AND OBJECTIVE: Formaldehyde is one of agents with absorbable potential which can use in industry and also in many productions such as technical, pharmaceutical and sanitary compounds. Previous study shown that formaldehyde can affect on testicular tissue and reduce spermatogenesis phenomena. This study was carried out to determine the effects of formaldehyde on leydig cells and testicular vasculogenesis.METHODS: Twenty mature male Balb/c mice were randomly divided into experimental and control groups (n=10). Experimental group were administered 0.25 mg/kg body weight dissolved formaldehyde intraperitoneally for 10 days. The control groups were received the same volume of normal saline during the same period of times. At the end of exposure time, animals were scarified and their testes were removed for processing, serially sectioned and immunohistochemistry by using PCNA method were carried out.FINDINGS: The finding revealed that the numerical density of leydig cells decreased significantly in experimental group in contrast controls (42 versus 66 per/m3 respectively). In addition, a number of shrinkage and picnotic leydig cells indicated occurrence of chromatolysis phenomena in experimental group.CONCLUSION: These data reveal that administration of formaldehyde may result in significant structural changes in male reproductive system such as interstitial tissue of seminiferous tubules and cell death among leydig cells population.
format	article
author	M.R. Nikravesh, M. Jalali, A.R. Fazel
author_facet	M.R. Nikravesh, M. Jalali, A.R. Fazel
author_sort	M.R. Nikravesh, M. Jalali, A.R. Fazel
title	EFFECT OF FORMALDEHYDE ON INTERSTITIAL TISSUE OF SEMINIFEROUS TUBULES IN TESTIS OF BALB/C MICE
title_short	EFFECT OF FORMALDEHYDE ON INTERSTITIAL TISSUE OF SEMINIFEROUS TUBULES IN TESTIS OF BALB/C MICE
title_full	EFFECT OF FORMALDEHYDE ON INTERSTITIAL TISSUE OF SEMINIFEROUS TUBULES IN TESTIS OF BALB/C MICE
title_fullStr	EFFECT OF FORMALDEHYDE ON INTERSTITIAL TISSUE OF SEMINIFEROUS TUBULES IN TESTIS OF BALB/C MICE
title_full_unstemmed	EFFECT OF FORMALDEHYDE ON INTERSTITIAL TISSUE OF SEMINIFEROUS TUBULES IN TESTIS OF BALB/C MICE
title_sort	effect of formaldehyde on interstitial tissue of seminiferous tubules in testis of balb/c mice
publisher	Babol University of Medical Sciences
publishDate	2009
url	https://doaj.org/article/141f65eb3e484c9193bfa6cff601523d
work_keys_str_mv	AT mrnikraveshmjalaliarfazel effectofformaldehydeoninterstitialtissueofseminiferoustubulesintestisofbalbcmice
_version_	1718440259991109632

EFFECT OF FORMALDEHYDE ON INTERSTITIAL TISSUE OF SEMINIFEROUS TUBULES IN TESTIS OF BALB/C MICE

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