Th2 and eosinophil responses suppress inflammatory arthritis

Type 2 immune responses are viewed as opposites of Type 1 and 17 responses. Here the authors show that activation of Type 2 immunity by helminth infection counteracts the development of inflammatory arthritis, a type 17-mediated pathology, via IL-4/IL-13- STAT6 signalling and eosinophil activation.

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Autores principales:	Zhu Chen, Darja Andreev, Katharina Oeser, Branislav Krljanac, Axel Hueber, Arnd Kleyer, David Voehringer, Georg Schett, Aline Bozec
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/14215b3bc91c4884a29bc4560ad6b232
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spelling	oai:doaj.org-article:14215b3bc91c4884a29bc4560ad6b2322021-12-02T17:31:32ZTh2 and eosinophil responses suppress inflammatory arthritis10.1038/ncomms115962041-1723https://doaj.org/article/14215b3bc91c4884a29bc4560ad6b2322016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11596https://doaj.org/toc/2041-1723Type 2 immune responses are viewed as opposites of Type 1 and 17 responses. Here the authors show that activation of Type 2 immunity by helminth infection counteracts the development of inflammatory arthritis, a type 17-mediated pathology, via IL-4/IL-13- STAT6 signalling and eosinophil activation.Zhu ChenDarja AndreevKatharina OeserBranislav KrljanacAxel HueberArnd KleyerDavid VoehringerGeorg SchettAline BozecNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhu Chen Darja Andreev Katharina Oeser Branislav Krljanac Axel Hueber Arnd Kleyer David Voehringer Georg Schett Aline Bozec Th2 and eosinophil responses suppress inflammatory arthritis
description	Type 2 immune responses are viewed as opposites of Type 1 and 17 responses. Here the authors show that activation of Type 2 immunity by helminth infection counteracts the development of inflammatory arthritis, a type 17-mediated pathology, via IL-4/IL-13- STAT6 signalling and eosinophil activation.
format	article
author	Zhu Chen Darja Andreev Katharina Oeser Branislav Krljanac Axel Hueber Arnd Kleyer David Voehringer Georg Schett Aline Bozec
author_facet	Zhu Chen Darja Andreev Katharina Oeser Branislav Krljanac Axel Hueber Arnd Kleyer David Voehringer Georg Schett Aline Bozec
author_sort	Zhu Chen
title	Th2 and eosinophil responses suppress inflammatory arthritis
title_short	Th2 and eosinophil responses suppress inflammatory arthritis
title_full	Th2 and eosinophil responses suppress inflammatory arthritis
title_fullStr	Th2 and eosinophil responses suppress inflammatory arthritis
title_full_unstemmed	Th2 and eosinophil responses suppress inflammatory arthritis
title_sort	th2 and eosinophil responses suppress inflammatory arthritis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/14215b3bc91c4884a29bc4560ad6b232
work_keys_str_mv	AT zhuchen th2andeosinophilresponsessuppressinflammatoryarthritis AT darjaandreev th2andeosinophilresponsessuppressinflammatoryarthritis AT katharinaoeser th2andeosinophilresponsessuppressinflammatoryarthritis AT branislavkrljanac th2andeosinophilresponsessuppressinflammatoryarthritis AT axelhueber th2andeosinophilresponsessuppressinflammatoryarthritis AT arndkleyer th2andeosinophilresponsessuppressinflammatoryarthritis AT davidvoehringer th2andeosinophilresponsessuppressinflammatoryarthritis AT georgschett th2andeosinophilresponsessuppressinflammatoryarthritis AT alinebozec th2andeosinophilresponsessuppressinflammatoryarthritis
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Th2 and eosinophil responses suppress inflammatory arthritis

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