Aberrant Cholesterol Metabolism in Ovarian Cancer: Identification of Novel Therapeutic Targets

Cholesterol is an essential substance in mammalian cells, and cholesterol metabolism plays crucial roles in multiple biological functions. Dysregulated cholesterol metabolism is a metabolic hallmark in several cancers, beyond the Warburg effect. Reprogrammed cholesterol metabolism has been reported...

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Autores principales:	Jiangnan He, Michelle K.Y. Siu, Hextan Y. S. Ngan, Karen K. L. Chan
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	cholesterol metabolism tumor microenvironment carcinogenesis therapeutic targets ovarian cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/14215ba38d5348b9a2ea319ee5ef080d
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id	oai:doaj.org-article:14215ba38d5348b9a2ea319ee5ef080d
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spelling	oai:doaj.org-article:14215ba38d5348b9a2ea319ee5ef080d2021-11-08T05:09:21ZAberrant Cholesterol Metabolism in Ovarian Cancer: Identification of Novel Therapeutic Targets2234-943X10.3389/fonc.2021.738177https://doaj.org/article/14215ba38d5348b9a2ea319ee5ef080d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.738177/fullhttps://doaj.org/toc/2234-943XCholesterol is an essential substance in mammalian cells, and cholesterol metabolism plays crucial roles in multiple biological functions. Dysregulated cholesterol metabolism is a metabolic hallmark in several cancers, beyond the Warburg effect. Reprogrammed cholesterol metabolism has been reported to enhance tumorigenesis, metastasis and chemoresistance in multiple cancer types, including ovarian cancer. Ovarian cancer is one of the most aggressive malignancies worldwide. Alterations in metabolic pathways are characteristic features of ovarian cancer; however, the specific role of cholesterol metabolism remains to be established. In this report, we provide an overview of the key proteins involved in cholesterol metabolism in ovarian cancer, including the rate-limiting enzymes in cholesterol biosynthesis, and the proteins involved in cholesterol uptake, storage and trafficking. Also, we review the roles of cholesterol and its derivatives in ovarian cancer and the tumor microenvironment, and discuss promising related therapeutic targets for ovarian cancer.Jiangnan HeMichelle K.Y. SiuHextan Y. S. NganKaren K. L. ChanFrontiers Media S.A.articlecholesterol metabolismtumor microenvironmentcarcinogenesistherapeutic targetsovarian cancerNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cholesterol metabolism tumor microenvironment carcinogenesis therapeutic targets ovarian cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	cholesterol metabolism tumor microenvironment carcinogenesis therapeutic targets ovarian cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Jiangnan He Michelle K.Y. Siu Hextan Y. S. Ngan Karen K. L. Chan Aberrant Cholesterol Metabolism in Ovarian Cancer: Identification of Novel Therapeutic Targets
description	Cholesterol is an essential substance in mammalian cells, and cholesterol metabolism plays crucial roles in multiple biological functions. Dysregulated cholesterol metabolism is a metabolic hallmark in several cancers, beyond the Warburg effect. Reprogrammed cholesterol metabolism has been reported to enhance tumorigenesis, metastasis and chemoresistance in multiple cancer types, including ovarian cancer. Ovarian cancer is one of the most aggressive malignancies worldwide. Alterations in metabolic pathways are characteristic features of ovarian cancer; however, the specific role of cholesterol metabolism remains to be established. In this report, we provide an overview of the key proteins involved in cholesterol metabolism in ovarian cancer, including the rate-limiting enzymes in cholesterol biosynthesis, and the proteins involved in cholesterol uptake, storage and trafficking. Also, we review the roles of cholesterol and its derivatives in ovarian cancer and the tumor microenvironment, and discuss promising related therapeutic targets for ovarian cancer.
format	article
author	Jiangnan He Michelle K.Y. Siu Hextan Y. S. Ngan Karen K. L. Chan
author_facet	Jiangnan He Michelle K.Y. Siu Hextan Y. S. Ngan Karen K. L. Chan
author_sort	Jiangnan He
title	Aberrant Cholesterol Metabolism in Ovarian Cancer: Identification of Novel Therapeutic Targets
title_short	Aberrant Cholesterol Metabolism in Ovarian Cancer: Identification of Novel Therapeutic Targets
title_full	Aberrant Cholesterol Metabolism in Ovarian Cancer: Identification of Novel Therapeutic Targets
title_fullStr	Aberrant Cholesterol Metabolism in Ovarian Cancer: Identification of Novel Therapeutic Targets
title_full_unstemmed	Aberrant Cholesterol Metabolism in Ovarian Cancer: Identification of Novel Therapeutic Targets
title_sort	aberrant cholesterol metabolism in ovarian cancer: identification of novel therapeutic targets
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/14215ba38d5348b9a2ea319ee5ef080d
work_keys_str_mv	AT jiangnanhe aberrantcholesterolmetabolisminovariancanceridentificationofnoveltherapeutictargets AT michellekysiu aberrantcholesterolmetabolisminovariancanceridentificationofnoveltherapeutictargets AT hextanysngan aberrantcholesterolmetabolisminovariancanceridentificationofnoveltherapeutictargets AT karenklchan aberrantcholesterolmetabolisminovariancanceridentificationofnoveltherapeutictargets
_version_	1718442881347223552

Aberrant Cholesterol Metabolism in Ovarian Cancer: Identification of Novel Therapeutic Targets

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