Effects of oxytocin and antagonist antidote atosiban on body weight and food intake of female mice, Mus musculus

Growing evidence suggests that oxytocin (OT) plays an important factor for the control of food intake, body weight, and energy metabolism in human and non-human animals. It has reported previously, the downregulation in oxytocin receptors (OTRs) expression is linked with the development of obesity,...

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Autores principales:	Pratibha Thakur, Renu Shrivastava, Vinoy K. Shrivastava
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Oxytocin Body weight Food intake Gonadosomatic indices Energy metabolism Physiology QP1-981 Biochemistry QD415-436
Acceso en línea:	https://doaj.org/article/142a0c3f04944cd49378f4e9d96de9ec
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id	oai:doaj.org-article:142a0c3f04944cd49378f4e9d96de9ec
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spelling	oai:doaj.org-article:142a0c3f04944cd49378f4e9d96de9ec2021-11-12T04:46:23ZEffects of oxytocin and antagonist antidote atosiban on body weight and food intake of female mice, Mus musculus2589-936810.1016/j.metop.2021.100146https://doaj.org/article/142a0c3f04944cd49378f4e9d96de9ec2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589936821000700https://doaj.org/toc/2589-9368Growing evidence suggests that oxytocin (OT) plays an important factor for the control of food intake, body weight, and energy metabolism in human and non-human animals. It has reported previously, the downregulation in oxytocin receptors (OTRs) expression is linked with the development of obesity, but exogenous OT reverse body weight and food intake in obese animal model. It is important to know that, whether intraperitoneal administration crosses blood brain barrier. Therefore, in the present experiment, we study the impact of intraperitoneal administration of synthetic OT 0.0116 mg/kg and antagonist atosiban (OTA) 1 mg/kg on food intake, and body weight of female mice, Mus musculus for different duration i.e. 30, 60, and 90 days. In this study, it was observed that there was significant decrease (p<0.001, one-way analysis of variance [ANOVA]) in the body weight (BW), food intake, and gonadosmatic indices (GSI) after the intraperitoneal exposure of OT at dose 0.0116 mg/kg up to 90 days and inhibits via antagonist atosiban. These results indicates that intraperitoneal administration of OT can be used for treatment for longer duration without any side effects and maintains homeostasis in physiologic system regulates body weight and gonadal weight in female mice, which represent an important therapeutic tool for the obesity and metabolic disorder in female.Pratibha ThakurRenu ShrivastavaVinoy K. ShrivastavaElsevierarticleOxytocinBody weightFood intakeGonadosomatic indicesEnergy metabolismPhysiologyQP1-981BiochemistryQD415-436ENMetabolism Open, Vol 12, Iss , Pp 100146- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Oxytocin Body weight Food intake Gonadosomatic indices Energy metabolism Physiology QP1-981 Biochemistry QD415-436
spellingShingle	Oxytocin Body weight Food intake Gonadosomatic indices Energy metabolism Physiology QP1-981 Biochemistry QD415-436 Pratibha Thakur Renu Shrivastava Vinoy K. Shrivastava Effects of oxytocin and antagonist antidote atosiban on body weight and food intake of female mice, Mus musculus
description	Growing evidence suggests that oxytocin (OT) plays an important factor for the control of food intake, body weight, and energy metabolism in human and non-human animals. It has reported previously, the downregulation in oxytocin receptors (OTRs) expression is linked with the development of obesity, but exogenous OT reverse body weight and food intake in obese animal model. It is important to know that, whether intraperitoneal administration crosses blood brain barrier. Therefore, in the present experiment, we study the impact of intraperitoneal administration of synthetic OT 0.0116 mg/kg and antagonist atosiban (OTA) 1 mg/kg on food intake, and body weight of female mice, Mus musculus for different duration i.e. 30, 60, and 90 days. In this study, it was observed that there was significant decrease (p<0.001, one-way analysis of variance [ANOVA]) in the body weight (BW), food intake, and gonadosmatic indices (GSI) after the intraperitoneal exposure of OT at dose 0.0116 mg/kg up to 90 days and inhibits via antagonist atosiban. These results indicates that intraperitoneal administration of OT can be used for treatment for longer duration without any side effects and maintains homeostasis in physiologic system regulates body weight and gonadal weight in female mice, which represent an important therapeutic tool for the obesity and metabolic disorder in female.
format	article
author	Pratibha Thakur Renu Shrivastava Vinoy K. Shrivastava
author_facet	Pratibha Thakur Renu Shrivastava Vinoy K. Shrivastava
author_sort	Pratibha Thakur
title	Effects of oxytocin and antagonist antidote atosiban on body weight and food intake of female mice, Mus musculus
title_short	Effects of oxytocin and antagonist antidote atosiban on body weight and food intake of female mice, Mus musculus
title_full	Effects of oxytocin and antagonist antidote atosiban on body weight and food intake of female mice, Mus musculus
title_fullStr	Effects of oxytocin and antagonist antidote atosiban on body weight and food intake of female mice, Mus musculus
title_full_unstemmed	Effects of oxytocin and antagonist antidote atosiban on body weight and food intake of female mice, Mus musculus
title_sort	effects of oxytocin and antagonist antidote atosiban on body weight and food intake of female mice, mus musculus
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/142a0c3f04944cd49378f4e9d96de9ec
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Effects of oxytocin and antagonist antidote atosiban on body weight and food intake of female mice, Mus musculus

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