From bench to bedside: use of human adipose-derived stem cells

Vaughan Feisst,1 Sarah Meidinger,1 Michelle B Locke2 1Dunbar Laboratory, School of Biological Sciences, 2Department of Surgery, Faculty of Medicine and Health Sciences, The University of Auckland, Auckland, New Zealand Abstract: Since the discovery of adipose-derived stem cells (ASC) in human adipos...

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Autores principales:	Feisst V, Meidinger S, Locke MB
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/142b749859044fa4999eb9b17226e7b7
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spelling	oai:doaj.org-article:142b749859044fa4999eb9b17226e7b72021-12-02T07:49:29ZFrom bench to bedside: use of human adipose-derived stem cells1178-6957https://doaj.org/article/142b749859044fa4999eb9b17226e7b72015-11-01T00:00:00Zhttps://www.dovepress.com/from-bench-to-bedside-use-of-human-adipose-derived-stem-cells-peer-reviewed-article-SCCAAhttps://doaj.org/toc/1178-6957Vaughan Feisst,1 Sarah Meidinger,1 Michelle B Locke2 1Dunbar Laboratory, School of Biological Sciences, 2Department of Surgery, Faculty of Medicine and Health Sciences, The University of Auckland, Auckland, New Zealand Abstract: Since the discovery of adipose-derived stem cells (ASC) in human adipose tissue nearly 15 years ago, significant advances have been made in progressing this promising cell therapy tool from the laboratory bench to bedside usage. Standardization of nomenclature around the different cell types used is finally being adopted, which facilitates comparison of results between research groups. In vitro studies have assessed the ability of ASC to undergo mesenchymal differentiation as well as differentiation along alternate lineages (transdifferentiation). Recently, focus has shifted to the immune modulatory and paracrine effects of transplanted ASC, with growing interest in the ASC secretome as a source of clinical effect. Bedside use of ASC is advancing alongside basic research. An increasing number of safety-focused Phase I and Phase IIb trials have been published without identifying any significant risks or adverse events in the short term. Phase III trials to assess efficacy are currently underway. In many countries, regulatory frameworks are being developed to monitor their use and assure their safety. As many trials rely on ASC injected at a distant site from the area of clinical need, strategies to improve the homing and efficacy of transplanted cells are also being explored. This review highlights each of these aspects of the bench-to-bedside use of ASC and summarizes their clinical utility across a variety of medical specialties. Keywords: standardization, bystander effect, stromal cells, mesenchymal stem cells, stromal vascular fractionFeisst VMeidinger SLocke MBDove Medical PressarticleCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol 2015, Iss default, Pp 149-162 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Feisst V Meidinger S Locke MB From bench to bedside: use of human adipose-derived stem cells
description	Vaughan Feisst,1 Sarah Meidinger,1 Michelle B Locke2 1Dunbar Laboratory, School of Biological Sciences, 2Department of Surgery, Faculty of Medicine and Health Sciences, The University of Auckland, Auckland, New Zealand Abstract: Since the discovery of adipose-derived stem cells (ASC) in human adipose tissue nearly 15 years ago, significant advances have been made in progressing this promising cell therapy tool from the laboratory bench to bedside usage. Standardization of nomenclature around the different cell types used is finally being adopted, which facilitates comparison of results between research groups. In vitro studies have assessed the ability of ASC to undergo mesenchymal differentiation as well as differentiation along alternate lineages (transdifferentiation). Recently, focus has shifted to the immune modulatory and paracrine effects of transplanted ASC, with growing interest in the ASC secretome as a source of clinical effect. Bedside use of ASC is advancing alongside basic research. An increasing number of safety-focused Phase I and Phase IIb trials have been published without identifying any significant risks or adverse events in the short term. Phase III trials to assess efficacy are currently underway. In many countries, regulatory frameworks are being developed to monitor their use and assure their safety. As many trials rely on ASC injected at a distant site from the area of clinical need, strategies to improve the homing and efficacy of transplanted cells are also being explored. This review highlights each of these aspects of the bench-to-bedside use of ASC and summarizes their clinical utility across a variety of medical specialties. Keywords: standardization, bystander effect, stromal cells, mesenchymal stem cells, stromal vascular fraction
format	article
author	Feisst V Meidinger S Locke MB
author_facet	Feisst V Meidinger S Locke MB
author_sort	Feisst V
title	From bench to bedside: use of human adipose-derived stem cells
title_short	From bench to bedside: use of human adipose-derived stem cells
title_full	From bench to bedside: use of human adipose-derived stem cells
title_fullStr	From bench to bedside: use of human adipose-derived stem cells
title_full_unstemmed	From bench to bedside: use of human adipose-derived stem cells
title_sort	from bench to bedside: use of human adipose-derived stem cells
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/142b749859044fa4999eb9b17226e7b7
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From bench to bedside: use of human adipose-derived stem cells

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