Nutritional Status as a Predictive Biomarker for Immunotherapy Outcomes in Advanced Head and Neck Cancer
The association between pretreatment nutritional status and immunotherapy response in patients with advanced head and neck cancer is unclear. We retrospectively analyzed a cohort of 99 patients who underwent treatment with anti-PD-1 or anti-CTLA-4 antibodies (or both) for stage IV HNSCC between 2014...
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MDPI AG
2021
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oai:doaj.org-article:142c6576243d47a39c94cf7c994228672021-11-25T17:03:51ZNutritional Status as a Predictive Biomarker for Immunotherapy Outcomes in Advanced Head and Neck Cancer10.3390/cancers132257722072-6694https://doaj.org/article/142c6576243d47a39c94cf7c994228672021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5772https://doaj.org/toc/2072-6694The association between pretreatment nutritional status and immunotherapy response in patients with advanced head and neck cancer is unclear. We retrospectively analyzed a cohort of 99 patients who underwent treatment with anti-PD-1 or anti-CTLA-4 antibodies (or both) for stage IV HNSCC between 2014 and 2020 at the Johns Hopkins Hospital. Patient demographics and clinical characteristics were retrieved from electronic medical records. Baseline prognostic nutritional index (PNI) scores and pretreatment body mass index (BMI) trends were calculated. Associations between PNI and BMI were correlated with overall survival (OS), progression-free survival (PFS), and immunotherapy response. In univariate analysis, there was a significant correlation between OS and PFS with baseline PNI (OS: HR: 0.464; 95% CI: 0.265–0.814; PFS: <i>p</i> = 0.007 and HR: 0.525; 95% CI: 0.341–0.808; <i>p</i> = 0.003). Poor OS was also associated with a greater decrease in pretreatment BMI trend (HR: 0.42; 95% CI: 0.229–0.77; <i>p</i> = 0.005). In multivariate analysis, baseline PNI but not BMI trend was significantly associated with OS and PFS (OS: log (HR) = −0.79, CI: −1.6, −0.03, <i>p</i> = 0.041; PFS: log (HR) = −0.78, CI: −1.4, −0.18, <i>p</i> = 0.011). In conclusion, poor pretreatment nutritional status is associated with negative post-immunotherapy outcomes.Meytal GullerMatthew HerbergNeha AminHosam AlkhatibChristopher MarounEvan WuHailey AllenYing ZhengChristine GourinPeter VoslerMarietta TanWayne KochDavid EiseleTanguy SeiwertCarole FakhryDrew PardollGangcai ZhuRajarsi MandalMDPI AGarticleprognostic nutritional indexbody mass indeximmunotherapyhead and neck cancernutritional statusoncologyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5772, p 5772 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
prognostic nutritional index body mass index immunotherapy head and neck cancer nutritional status oncology Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
| spellingShingle |
prognostic nutritional index body mass index immunotherapy head and neck cancer nutritional status oncology Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Meytal Guller Matthew Herberg Neha Amin Hosam Alkhatib Christopher Maroun Evan Wu Hailey Allen Ying Zheng Christine Gourin Peter Vosler Marietta Tan Wayne Koch David Eisele Tanguy Seiwert Carole Fakhry Drew Pardoll Gangcai Zhu Rajarsi Mandal Nutritional Status as a Predictive Biomarker for Immunotherapy Outcomes in Advanced Head and Neck Cancer |
| description |
The association between pretreatment nutritional status and immunotherapy response in patients with advanced head and neck cancer is unclear. We retrospectively analyzed a cohort of 99 patients who underwent treatment with anti-PD-1 or anti-CTLA-4 antibodies (or both) for stage IV HNSCC between 2014 and 2020 at the Johns Hopkins Hospital. Patient demographics and clinical characteristics were retrieved from electronic medical records. Baseline prognostic nutritional index (PNI) scores and pretreatment body mass index (BMI) trends were calculated. Associations between PNI and BMI were correlated with overall survival (OS), progression-free survival (PFS), and immunotherapy response. In univariate analysis, there was a significant correlation between OS and PFS with baseline PNI (OS: HR: 0.464; 95% CI: 0.265–0.814; PFS: <i>p</i> = 0.007 and HR: 0.525; 95% CI: 0.341–0.808; <i>p</i> = 0.003). Poor OS was also associated with a greater decrease in pretreatment BMI trend (HR: 0.42; 95% CI: 0.229–0.77; <i>p</i> = 0.005). In multivariate analysis, baseline PNI but not BMI trend was significantly associated with OS and PFS (OS: log (HR) = −0.79, CI: −1.6, −0.03, <i>p</i> = 0.041; PFS: log (HR) = −0.78, CI: −1.4, −0.18, <i>p</i> = 0.011). In conclusion, poor pretreatment nutritional status is associated with negative post-immunotherapy outcomes. |
| format |
article |
| author |
Meytal Guller Matthew Herberg Neha Amin Hosam Alkhatib Christopher Maroun Evan Wu Hailey Allen Ying Zheng Christine Gourin Peter Vosler Marietta Tan Wayne Koch David Eisele Tanguy Seiwert Carole Fakhry Drew Pardoll Gangcai Zhu Rajarsi Mandal |
| author_facet |
Meytal Guller Matthew Herberg Neha Amin Hosam Alkhatib Christopher Maroun Evan Wu Hailey Allen Ying Zheng Christine Gourin Peter Vosler Marietta Tan Wayne Koch David Eisele Tanguy Seiwert Carole Fakhry Drew Pardoll Gangcai Zhu Rajarsi Mandal |
| author_sort |
Meytal Guller |
| title |
Nutritional Status as a Predictive Biomarker for Immunotherapy Outcomes in Advanced Head and Neck Cancer |
| title_short |
Nutritional Status as a Predictive Biomarker for Immunotherapy Outcomes in Advanced Head and Neck Cancer |
| title_full |
Nutritional Status as a Predictive Biomarker for Immunotherapy Outcomes in Advanced Head and Neck Cancer |
| title_fullStr |
Nutritional Status as a Predictive Biomarker for Immunotherapy Outcomes in Advanced Head and Neck Cancer |
| title_full_unstemmed |
Nutritional Status as a Predictive Biomarker for Immunotherapy Outcomes in Advanced Head and Neck Cancer |
| title_sort |
nutritional status as a predictive biomarker for immunotherapy outcomes in advanced head and neck cancer |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/142c6576243d47a39c94cf7c99422867 |
| work_keys_str_mv |
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| _version_ |
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