The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases

YTHDF1 is the most versatile and powerful reader protein of N6-methyladenosine (m6A)-modified RNA, and it can recognize both G(m6A)C and A(m6A)C RNAs as ligands without sequence selectivity. YTHDF1 regulates target gene expression by different mechanisms, such as promoting translation or regulating...

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Autores principales:	Zuyao Chen, Xiaolin Zhong, Min Xia, Jing Zhong
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	YTHDF1 N6-methyladenosine m6A protein translation mRNA stability tumor biology Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/142ccd92499b4b4d8c3601d6ecd4dc60
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spelling	oai:doaj.org-article:142ccd92499b4b4d8c3601d6ecd4dc602021-11-22T04:23:39ZThe roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases2162-253110.1016/j.omtn.2021.10.023https://doaj.org/article/142ccd92499b4b4d8c3601d6ecd4dc602021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2162253121002663https://doaj.org/toc/2162-2531YTHDF1 is the most versatile and powerful reader protein of N6-methyladenosine (m6A)-modified RNA, and it can recognize both G(m6A)C and A(m6A)C RNAs as ligands without sequence selectivity. YTHDF1 regulates target gene expression by different mechanisms, such as promoting translation or regulating the stability of mRNA. Numerous studies have shown that YTHDF1 plays an important role in tumor biology and nontumor lesions by mediating the protein translation of important genes or by affecting the expression of key factors involved in many important cell signaling pathways. Therefore, in this review we focus on some of the roles of YTHDF1 in tumor biology and diseases.Zuyao ChenXiaolin ZhongMin XiaJing ZhongElsevierarticleYTHDF1N6-methyladenosinem6Aprotein translationmRNA stabilitytumor biologyTherapeutics. PharmacologyRM1-950ENMolecular Therapy: Nucleic Acids, Vol 26, Iss , Pp 1270-1279 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	YTHDF1 N6-methyladenosine m6A protein translation mRNA stability tumor biology Therapeutics. Pharmacology RM1-950
spellingShingle	YTHDF1 N6-methyladenosine m6A protein translation mRNA stability tumor biology Therapeutics. Pharmacology RM1-950 Zuyao Chen Xiaolin Zhong Min Xia Jing Zhong The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases
description	YTHDF1 is the most versatile and powerful reader protein of N6-methyladenosine (m6A)-modified RNA, and it can recognize both G(m6A)C and A(m6A)C RNAs as ligands without sequence selectivity. YTHDF1 regulates target gene expression by different mechanisms, such as promoting translation or regulating the stability of mRNA. Numerous studies have shown that YTHDF1 plays an important role in tumor biology and nontumor lesions by mediating the protein translation of important genes or by affecting the expression of key factors involved in many important cell signaling pathways. Therefore, in this review we focus on some of the roles of YTHDF1 in tumor biology and diseases.
format	article
author	Zuyao Chen Xiaolin Zhong Min Xia Jing Zhong
author_facet	Zuyao Chen Xiaolin Zhong Min Xia Jing Zhong
author_sort	Zuyao Chen
title	The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases
title_short	The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases
title_full	The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases
title_fullStr	The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases
title_full_unstemmed	The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases
title_sort	roles and mechanisms of the m6a reader protein ythdf1 in tumor biology and human diseases
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/142ccd92499b4b4d8c3601d6ecd4dc60
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The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases

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