Exposure to titanium dioxide and other metallic oxide nanoparticles induces cytotoxicity on human neural cells and fibroblasts

James C K Lai1, Maria B Lai1, Sirisha Jandhyam1, Vikas V Dukhande1, Alok Bhushan1, Christopher K Daniels1, Solomon W Leung21Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, and Biomedical Research Institute; 2Department of Civil and Environmental Engineering, College of Eng...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	James C K Lai, Maria B Lai, Sirisha Jandhyam, Vikas V Dukhande, Alok Bhushan, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/142da0a434284cd18aea897ef419edb7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:142da0a434284cd18aea897ef419edb7
record_format	dspace
spelling	oai:doaj.org-article:142da0a434284cd18aea897ef419edb72021-12-02T07:37:04ZExposure to titanium dioxide and other metallic oxide nanoparticles induces cytotoxicity on human neural cells and fibroblasts1176-91141178-2013https://doaj.org/article/142da0a434284cd18aea897ef419edb72008-12-01T00:00:00Zhttp://www.dovepress.com/exposure-to-titanium-dioxide-and-other-metallic-oxide-nanoparticles-in-a2726https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013James C K Lai1, Maria B Lai1, Sirisha Jandhyam1, Vikas V Dukhande1, Alok Bhushan1, Christopher K Daniels1, Solomon W Leung21Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, and Biomedical Research Institute; 2Department of Civil and Environmental Engineering, College of Engineering and Biomedical Research Institute, Idaho State University, Pocatello, ID, USAAbstract: The use of titanium dioxide (TiO2) in various industrial applications (eg, production of paper, plastics, cosmetics, and paints) has been expanding thereby increasing the occupational and other environmental exposure of these nanoparticles to humans and other species. However, the health effects of exposure to TiO2 nanoparticles have not been systematically assessed even though recent studies suggest that such exposure induces inflammatory responses in lung tissue and cells. Because the effects of such nanoparticles on human neural cells are unknown, we have determined the putative cytotoxic effects of these nanoparticles on human astrocytes-like astrocytoma U87 cells and compared their effects on normal human fibroblasts. We found that TiO2 micro- and nanoparticles induced cell death on both human cell types in a concentration-related manner. We further noted that zinc oxide (ZnO) nanoparticles were the most effective, TiO2 nanoparticles the second most effective, and magnesium oxide (MgO) nanoparticles the least effective in inducing cell death in U87 cells. The cell death mechanisms underlying the effects of TiO2&nbsp;micro- and nanoparticles on U87 cells include apoptosis, necrosis, and possibly apoptosis-like and necrosis-like cell death types. Thus, our findings may have toxicological and other pathophysiological implications on exposure of humans and other mammalian species to metallic oxide nanoparticles.Keywords: cytotoxicity of titanium dioxide micro- and nanoparticles, cytotoxicity of zinc oxide and magnesium oxide nanoparticles, human neural cells, human fibroblasts, nanotoxicity, cell death mechanisms James C K LaiMaria B LaiSirisha JandhyamVikas V DukhandeAlok Bhushanet alDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2008, Iss Issue 4, Pp 533-545 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 James C K Lai Maria B Lai Sirisha Jandhyam Vikas V Dukhande Alok Bhushan et al Exposure to titanium dioxide and other metallic oxide nanoparticles induces cytotoxicity on human neural cells and fibroblasts
description	James C K Lai1, Maria B Lai1, Sirisha Jandhyam1, Vikas V Dukhande1, Alok Bhushan1, Christopher K Daniels1, Solomon W Leung21Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, and Biomedical Research Institute; 2Department of Civil and Environmental Engineering, College of Engineering and Biomedical Research Institute, Idaho State University, Pocatello, ID, USAAbstract: The use of titanium dioxide (TiO2) in various industrial applications (eg, production of paper, plastics, cosmetics, and paints) has been expanding thereby increasing the occupational and other environmental exposure of these nanoparticles to humans and other species. However, the health effects of exposure to TiO2 nanoparticles have not been systematically assessed even though recent studies suggest that such exposure induces inflammatory responses in lung tissue and cells. Because the effects of such nanoparticles on human neural cells are unknown, we have determined the putative cytotoxic effects of these nanoparticles on human astrocytes-like astrocytoma U87 cells and compared their effects on normal human fibroblasts. We found that TiO2 micro- and nanoparticles induced cell death on both human cell types in a concentration-related manner. We further noted that zinc oxide (ZnO) nanoparticles were the most effective, TiO2 nanoparticles the second most effective, and magnesium oxide (MgO) nanoparticles the least effective in inducing cell death in U87 cells. The cell death mechanisms underlying the effects of TiO2&nbsp;micro- and nanoparticles on U87 cells include apoptosis, necrosis, and possibly apoptosis-like and necrosis-like cell death types. Thus, our findings may have toxicological and other pathophysiological implications on exposure of humans and other mammalian species to metallic oxide nanoparticles.Keywords: cytotoxicity of titanium dioxide micro- and nanoparticles, cytotoxicity of zinc oxide and magnesium oxide nanoparticles, human neural cells, human fibroblasts, nanotoxicity, cell death mechanisms
format	article
author	James C K Lai Maria B Lai Sirisha Jandhyam Vikas V Dukhande Alok Bhushan et al
author_facet	James C K Lai Maria B Lai Sirisha Jandhyam Vikas V Dukhande Alok Bhushan et al
author_sort	James C K Lai
title	Exposure to titanium dioxide and other metallic oxide nanoparticles induces cytotoxicity on human neural cells and fibroblasts
title_short	Exposure to titanium dioxide and other metallic oxide nanoparticles induces cytotoxicity on human neural cells and fibroblasts
title_full	Exposure to titanium dioxide and other metallic oxide nanoparticles induces cytotoxicity on human neural cells and fibroblasts
title_fullStr	Exposure to titanium dioxide and other metallic oxide nanoparticles induces cytotoxicity on human neural cells and fibroblasts
title_full_unstemmed	Exposure to titanium dioxide and other metallic oxide nanoparticles induces cytotoxicity on human neural cells and fibroblasts
title_sort	exposure to titanium dioxide and other metallic oxide nanoparticles induces cytotoxicity on human neural cells and fibroblasts
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/142da0a434284cd18aea897ef419edb7
work_keys_str_mv	AT jamescklai exposuretotitaniumdioxideandothermetallicoxidenanoparticlesinducescytotoxicityonhumanneuralcellsandfibroblasts AT mariablai exposuretotitaniumdioxideandothermetallicoxidenanoparticlesinducescytotoxicityonhumanneuralcellsandfibroblasts AT sirishajandhyam exposuretotitaniumdioxideandothermetallicoxidenanoparticlesinducescytotoxicityonhumanneuralcellsandfibroblasts AT vikasvdukhande exposuretotitaniumdioxideandothermetallicoxidenanoparticlesinducescytotoxicityonhumanneuralcellsandfibroblasts AT alokbhushan exposuretotitaniumdioxideandothermetallicoxidenanoparticlesinducescytotoxicityonhumanneuralcellsandfibroblasts AT etal exposuretotitaniumdioxideandothermetallicoxidenanoparticlesinducescytotoxicityonhumanneuralcellsandfibroblasts
_version_	1718399264246202368

Exposure to titanium dioxide and other metallic oxide nanoparticles induces cytotoxicity on human neural cells and fibroblasts

Ejemplares similares