From DNA Damage to Cancer Progression: Potential Effects of Cytolethal Distending Toxin

Cytolethal distending toxin (CDT), one of the most important genotoxins, is produced by several gram-negative bacteria and is involved in bacterial pathogenesis. Recent studies have shown that bacteria producing this peculiar genotoxin target host DNA, which potentially contributes to development of...

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Autores principales:	Yi-Ru Lai, Yu-Fang Chang, Jason Ma, Cheng-Hsun Chiu, Ming-Ling Kuo, Chih-Ho Lai
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	bacterial genotoxin cytolethal distending toxin DNA damage genotoxicity cancer development Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/1430b766d95e44a594c09933b2f73277
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spelling	oai:doaj.org-article:1430b766d95e44a594c09933b2f732772021-11-15T06:00:48ZFrom DNA Damage to Cancer Progression: Potential Effects of Cytolethal Distending Toxin1664-322410.3389/fimmu.2021.760451https://doaj.org/article/1430b766d95e44a594c09933b2f732772021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.760451/fullhttps://doaj.org/toc/1664-3224Cytolethal distending toxin (CDT), one of the most important genotoxins, is produced by several gram-negative bacteria and is involved in bacterial pathogenesis. Recent studies have shown that bacteria producing this peculiar genotoxin target host DNA, which potentially contributes to development of cancer. In this review, we highlighted the recent studies focusing on the idea that CDT leads to DNA damage, and the cells with inappropriately repaired DNA continue cycling, resulting in cancer development. Understanding the detailed mechanisms of genotoxins that cause DNA damage might be useful for targeting potential markers that drive cancer progression and help to discover new therapeutic strategies to prevent diseases caused by pathogens.Yi-Ru LaiYi-Ru LaiYu-Fang ChangYu-Fang ChangJason MaJason MaCheng-Hsun ChiuCheng-Hsun ChiuCheng-Hsun ChiuMing-Ling KuoMing-Ling KuoMing-Ling KuoChih-Ho LaiChih-Ho LaiChih-Ho LaiChih-Ho LaiChih-Ho LaiFrontiers Media S.A.articlebacterial genotoxincytolethal distending toxinDNA damagegenotoxicitycancer developmentImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bacterial genotoxin cytolethal distending toxin DNA damage genotoxicity cancer development Immunologic diseases. Allergy RC581-607
spellingShingle	bacterial genotoxin cytolethal distending toxin DNA damage genotoxicity cancer development Immunologic diseases. Allergy RC581-607 Yi-Ru Lai Yi-Ru Lai Yu-Fang Chang Yu-Fang Chang Jason Ma Jason Ma Cheng-Hsun Chiu Cheng-Hsun Chiu Cheng-Hsun Chiu Ming-Ling Kuo Ming-Ling Kuo Ming-Ling Kuo Chih-Ho Lai Chih-Ho Lai Chih-Ho Lai Chih-Ho Lai Chih-Ho Lai From DNA Damage to Cancer Progression: Potential Effects of Cytolethal Distending Toxin
description	Cytolethal distending toxin (CDT), one of the most important genotoxins, is produced by several gram-negative bacteria and is involved in bacterial pathogenesis. Recent studies have shown that bacteria producing this peculiar genotoxin target host DNA, which potentially contributes to development of cancer. In this review, we highlighted the recent studies focusing on the idea that CDT leads to DNA damage, and the cells with inappropriately repaired DNA continue cycling, resulting in cancer development. Understanding the detailed mechanisms of genotoxins that cause DNA damage might be useful for targeting potential markers that drive cancer progression and help to discover new therapeutic strategies to prevent diseases caused by pathogens.
format	article
author	Yi-Ru Lai Yi-Ru Lai Yu-Fang Chang Yu-Fang Chang Jason Ma Jason Ma Cheng-Hsun Chiu Cheng-Hsun Chiu Cheng-Hsun Chiu Ming-Ling Kuo Ming-Ling Kuo Ming-Ling Kuo Chih-Ho Lai Chih-Ho Lai Chih-Ho Lai Chih-Ho Lai Chih-Ho Lai
author_facet	Yi-Ru Lai Yi-Ru Lai Yu-Fang Chang Yu-Fang Chang Jason Ma Jason Ma Cheng-Hsun Chiu Cheng-Hsun Chiu Cheng-Hsun Chiu Ming-Ling Kuo Ming-Ling Kuo Ming-Ling Kuo Chih-Ho Lai Chih-Ho Lai Chih-Ho Lai Chih-Ho Lai Chih-Ho Lai
author_sort	Yi-Ru Lai
title	From DNA Damage to Cancer Progression: Potential Effects of Cytolethal Distending Toxin
title_short	From DNA Damage to Cancer Progression: Potential Effects of Cytolethal Distending Toxin
title_full	From DNA Damage to Cancer Progression: Potential Effects of Cytolethal Distending Toxin
title_fullStr	From DNA Damage to Cancer Progression: Potential Effects of Cytolethal Distending Toxin
title_full_unstemmed	From DNA Damage to Cancer Progression: Potential Effects of Cytolethal Distending Toxin
title_sort	from dna damage to cancer progression: potential effects of cytolethal distending toxin
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/1430b766d95e44a594c09933b2f73277
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From DNA Damage to Cancer Progression: Potential Effects of Cytolethal Distending Toxin

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