Incidence and evolution of venous thrombosis during the first 3 months after irreversible electroporation of malignant hepatic tumours

Abstract The incidence and evolution of venous thrombosis adjacent to the ablation zone after percutaneous irreversible electroporation (IRE) were evaluated to identify potential risk factors in patients with hepatic malignancies. 205 venous structures (in 87 patients) within a ≤1.0 cm radius of the...

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Autores principales:	W. Bäumler, M. Sebald, I. Einspieler, P. Wiggermann, A. Schicho, J. Schaible, L. Lürken, M. Dollinger, C. Stroszczynski, L. P. Beyer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/14317a8c59c94af8a09d30f5dcbd16c3
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spelling	oai:doaj.org-article:14317a8c59c94af8a09d30f5dcbd16c32021-12-02T13:35:02ZIncidence and evolution of venous thrombosis during the first 3 months after irreversible electroporation of malignant hepatic tumours10.1038/s41598-019-56324-y2045-2322https://doaj.org/article/14317a8c59c94af8a09d30f5dcbd16c32019-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-56324-yhttps://doaj.org/toc/2045-2322Abstract The incidence and evolution of venous thrombosis adjacent to the ablation zone after percutaneous irreversible electroporation (IRE) were evaluated to identify potential risk factors in patients with hepatic malignancies. 205 venous structures (in 87 patients) within a ≤1.0 cm radius of the ablation zone were assessed after IRE of 112 hepatic lesions (74 primary, 38 secondary hepatic malignancies) by pre-interventional and post-interventional (1–3 days, 6 weeks and 3 months after IRE) contrast-enhanced magnetic resonance imaging. The relationships between venous thrombosis and clinical features were analysed using a binary logistic regression model. In 27 of 87 patients (31%), a total of 67 venous complications were noted during the 3 months follow-up. Thrombosis represented the most frequently observed complication (n = 47; 70.1%), followed by vessel narrowing (n = 20; 29.9%). 5 (10.6%) of 47 thromboses showed spontaneous regression 3 months after IRE. A small vessel diameter (p = 0.011) and post-interventional vessel narrowing (p = 0.006) were independently associated with delayed post-ablative thrombosis. Delayed venous thrombosis frequently occurs after IRE of hepatic malignancies. Pre-existing vessel narrowing and a small vessel diameter represent significant risk factors that require further surveillance and potentially therapeutic intervention.W. BäumlerM. SebaldI. EinspielerP. WiggermannA. SchichoJ. SchaibleL. LürkenM. DollingerC. StroszczynskiL. P. BeyerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-7 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q W. Bäumler M. Sebald I. Einspieler P. Wiggermann A. Schicho J. Schaible L. Lürken M. Dollinger C. Stroszczynski L. P. Beyer Incidence and evolution of venous thrombosis during the first 3 months after irreversible electroporation of malignant hepatic tumours
description	Abstract The incidence and evolution of venous thrombosis adjacent to the ablation zone after percutaneous irreversible electroporation (IRE) were evaluated to identify potential risk factors in patients with hepatic malignancies. 205 venous structures (in 87 patients) within a ≤1.0 cm radius of the ablation zone were assessed after IRE of 112 hepatic lesions (74 primary, 38 secondary hepatic malignancies) by pre-interventional and post-interventional (1–3 days, 6 weeks and 3 months after IRE) contrast-enhanced magnetic resonance imaging. The relationships between venous thrombosis and clinical features were analysed using a binary logistic regression model. In 27 of 87 patients (31%), a total of 67 venous complications were noted during the 3 months follow-up. Thrombosis represented the most frequently observed complication (n = 47; 70.1%), followed by vessel narrowing (n = 20; 29.9%). 5 (10.6%) of 47 thromboses showed spontaneous regression 3 months after IRE. A small vessel diameter (p = 0.011) and post-interventional vessel narrowing (p = 0.006) were independently associated with delayed post-ablative thrombosis. Delayed venous thrombosis frequently occurs after IRE of hepatic malignancies. Pre-existing vessel narrowing and a small vessel diameter represent significant risk factors that require further surveillance and potentially therapeutic intervention.
format	article
author	W. Bäumler M. Sebald I. Einspieler P. Wiggermann A. Schicho J. Schaible L. Lürken M. Dollinger C. Stroszczynski L. P. Beyer
author_facet	W. Bäumler M. Sebald I. Einspieler P. Wiggermann A. Schicho J. Schaible L. Lürken M. Dollinger C. Stroszczynski L. P. Beyer
author_sort	W. Bäumler
title	Incidence and evolution of venous thrombosis during the first 3 months after irreversible electroporation of malignant hepatic tumours
title_short	Incidence and evolution of venous thrombosis during the first 3 months after irreversible electroporation of malignant hepatic tumours
title_full	Incidence and evolution of venous thrombosis during the first 3 months after irreversible electroporation of malignant hepatic tumours
title_fullStr	Incidence and evolution of venous thrombosis during the first 3 months after irreversible electroporation of malignant hepatic tumours
title_full_unstemmed	Incidence and evolution of venous thrombosis during the first 3 months after irreversible electroporation of malignant hepatic tumours
title_sort	incidence and evolution of venous thrombosis during the first 3 months after irreversible electroporation of malignant hepatic tumours
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/14317a8c59c94af8a09d30f5dcbd16c3
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Incidence and evolution of venous thrombosis during the first 3 months after irreversible electroporation of malignant hepatic tumours

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