Spiny mice activate unique transcriptional programs after severe kidney injury regenerating organ function without fibrosis

Summary: Fibrosis-driven solid organ failure is an enormous burden on global health. Spiny mice (Acomys) are terrestrial mammals that can regenerate severe skin wounds without scars to avoid predation. Whether spiny mice also regenerate internal organ injuries is unknown. Here, we show that despite...

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Autores principales:	Daryl M. Okamura, Chris M. Brewer, Paul Wakenight, Nadia Bahrami, Kristina Bernardi, Amy Tran, Jill Olson, Xiaogang Shi, Szu-Ying Yeh, Adrian Piliponsky, Sarah J. Collins, Elizabeth D. Nguyen, Andrew E. Timms, James W. MacDonald, Theo K. Bammler, Branden R. Nelson, Kathleen J. Millen, David R. Beier, Mark W. Majesky
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Animal physiology Molecular biology Developmental biology Science Q
Acceso en línea:	https://doaj.org/article/14339f301a224e7fbcad8ed0416f3953
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spelling	oai:doaj.org-article:14339f301a224e7fbcad8ed0416f39532021-11-20T05:09:06ZSpiny mice activate unique transcriptional programs after severe kidney injury regenerating organ function without fibrosis2589-004210.1016/j.isci.2021.103269https://doaj.org/article/14339f301a224e7fbcad8ed0416f39532021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221012384https://doaj.org/toc/2589-0042Summary: Fibrosis-driven solid organ failure is an enormous burden on global health. Spiny mice (Acomys) are terrestrial mammals that can regenerate severe skin wounds without scars to avoid predation. Whether spiny mice also regenerate internal organ injuries is unknown. Here, we show that despite equivalent acute obstructive or ischemic kidney injury, spiny mice fully regenerate nephron structure and organ function without fibrosis, whereas C57Bl/6 or CD1 mice progress to complete organ failure with extensive renal fibrosis. Two mechanisms for vertebrate regeneration have been proposed that emphasize either extrinsic (pro-regenerative macrophages) or intrinsic (surviving cells of the organ itself) controls. Comparative transcriptome analysis revealed that the Acomys genome appears poised at the time of injury to initiate regeneration by surviving kidney cells, whereas macrophage accumulation was not detected until about day 7. Thus, we provide evidence for rapid activation of a gene expression signature for regenerative wound healing in the spiny mouse kidney.Daryl M. OkamuraChris M. BrewerPaul WakenightNadia BahramiKristina BernardiAmy TranJill OlsonXiaogang ShiSzu-Ying YehAdrian PiliponskySarah J. CollinsElizabeth D. NguyenAndrew E. TimmsJames W. MacDonaldTheo K. BammlerBranden R. NelsonKathleen J. MillenDavid R. BeierMark W. MajeskyElsevierarticleAnimal physiologyMolecular biologyDevelopmental biologyScienceQENiScience, Vol 24, Iss 11, Pp 103269- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Animal physiology Molecular biology Developmental biology Science Q
spellingShingle	Animal physiology Molecular biology Developmental biology Science Q Daryl M. Okamura Chris M. Brewer Paul Wakenight Nadia Bahrami Kristina Bernardi Amy Tran Jill Olson Xiaogang Shi Szu-Ying Yeh Adrian Piliponsky Sarah J. Collins Elizabeth D. Nguyen Andrew E. Timms James W. MacDonald Theo K. Bammler Branden R. Nelson Kathleen J. Millen David R. Beier Mark W. Majesky Spiny mice activate unique transcriptional programs after severe kidney injury regenerating organ function without fibrosis
description	Summary: Fibrosis-driven solid organ failure is an enormous burden on global health. Spiny mice (Acomys) are terrestrial mammals that can regenerate severe skin wounds without scars to avoid predation. Whether spiny mice also regenerate internal organ injuries is unknown. Here, we show that despite equivalent acute obstructive or ischemic kidney injury, spiny mice fully regenerate nephron structure and organ function without fibrosis, whereas C57Bl/6 or CD1 mice progress to complete organ failure with extensive renal fibrosis. Two mechanisms for vertebrate regeneration have been proposed that emphasize either extrinsic (pro-regenerative macrophages) or intrinsic (surviving cells of the organ itself) controls. Comparative transcriptome analysis revealed that the Acomys genome appears poised at the time of injury to initiate regeneration by surviving kidney cells, whereas macrophage accumulation was not detected until about day 7. Thus, we provide evidence for rapid activation of a gene expression signature for regenerative wound healing in the spiny mouse kidney.
format	article
author	Daryl M. Okamura Chris M. Brewer Paul Wakenight Nadia Bahrami Kristina Bernardi Amy Tran Jill Olson Xiaogang Shi Szu-Ying Yeh Adrian Piliponsky Sarah J. Collins Elizabeth D. Nguyen Andrew E. Timms James W. MacDonald Theo K. Bammler Branden R. Nelson Kathleen J. Millen David R. Beier Mark W. Majesky
author_facet	Daryl M. Okamura Chris M. Brewer Paul Wakenight Nadia Bahrami Kristina Bernardi Amy Tran Jill Olson Xiaogang Shi Szu-Ying Yeh Adrian Piliponsky Sarah J. Collins Elizabeth D. Nguyen Andrew E. Timms James W. MacDonald Theo K. Bammler Branden R. Nelson Kathleen J. Millen David R. Beier Mark W. Majesky
author_sort	Daryl M. Okamura
title	Spiny mice activate unique transcriptional programs after severe kidney injury regenerating organ function without fibrosis
title_short	Spiny mice activate unique transcriptional programs after severe kidney injury regenerating organ function without fibrosis
title_full	Spiny mice activate unique transcriptional programs after severe kidney injury regenerating organ function without fibrosis
title_fullStr	Spiny mice activate unique transcriptional programs after severe kidney injury regenerating organ function without fibrosis
title_full_unstemmed	Spiny mice activate unique transcriptional programs after severe kidney injury regenerating organ function without fibrosis
title_sort	spiny mice activate unique transcriptional programs after severe kidney injury regenerating organ function without fibrosis
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/14339f301a224e7fbcad8ed0416f3953
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Spiny mice activate unique transcriptional programs after severe kidney injury regenerating organ function without fibrosis

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