Spiny mice activate unique transcriptional programs after severe kidney injury regenerating organ function without fibrosis

Spiny mice activate unique transcriptional programs after severe kidney injury regenerating organ function without fibrosis

Summary: Fibrosis-driven solid organ failure is an enormous burden on global health. Spiny mice (Acomys) are terrestrial mammals that can regenerate severe skin wounds without scars to avoid predation. Whether spiny mice also regenerate internal organ injuries is unknown. Here, we show that despite...

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Auteurs principaux: Daryl M. Okamura, Chris M. Brewer, Paul Wakenight, Nadia Bahrami, Kristina Bernardi, Amy Tran, Jill Olson, Xiaogang Shi, Szu-Ying Yeh, Adrian Piliponsky, Sarah J. Collins, Elizabeth D. Nguyen, Andrew E. Timms, James W. MacDonald, Theo K. Bammler, Branden R. Nelson, Kathleen J. Millen, David R. Beier, Mark W. Majesky
Format: article
Langue:EN
Publié: Elsevier 2021
Sujets:
Animal physiology
Molecular biology
Developmental biology
Science
Q
Accès en ligne:https://doaj.org/article/14339f301a224e7fbcad8ed0416f3953
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