ACTIVATION OF T. GONDII INFECTION AFTER ALLOGENEIC TRANSPLANTATION OF HEMATOPOIETIC STEM CELLS: DEPENDENCE ON TIME OF TRANSPLANTATION AND SEROLOGICAL STATUS OF THE PATIENTS

The article focuses on aspects of T. gondii reactivation/reinfection in patients undergoing allogeneic hematopoietic stem cell transplantation (alloHSCT). We have observed 297 patients who received conditioning therapy and allogeneic grafts due to different oncohematological or lymphoproliferative d...

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Autores principales:	A. B. Chukhlovin, L. S. Zubarovskaya, S. N. Bondarenko, Yu. A. Eismont, A. V. Semenov, M. D. Vladovskaya, Areg A. Totolian, B. V. Afanasyev
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2015
Materias:	hematopoietic stem cell transplantation toxoplasma gondii reactivation dna diagnostics igg antibodies Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/1434dd6499444942a9a35bdd0d2972bc
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spelling	oai:doaj.org-article:1434dd6499444942a9a35bdd0d2972bc2021-11-22T07:09:47ZACTIVATION OF T. GONDII INFECTION AFTER ALLOGENEIC TRANSPLANTATION OF HEMATOPOIETIC STEM CELLS: DEPENDENCE ON TIME OF TRANSPLANTATION AND SEROLOGICAL STATUS OF THE PATIENTS2220-76192313-739810.15789/2220-7619-2014-4-381-386https://doaj.org/article/1434dd6499444942a9a35bdd0d2972bc2015-02-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/250https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398The article focuses on aspects of T. gondii reactivation/reinfection in patients undergoing allogeneic hematopoietic stem cell transplantation (alloHSCT). We have observed 297 patients who received conditioning therapy and allogeneic grafts due to different oncohematological or lymphoproliferative diseases (1 to 60 years old, at a mediane of 19 years). Conditioning regimens were either myeloablative (35%), or non-myeloablative (65%). DNA diagnostics of T. gondii was performed on a regular basis at 0 to 6 months post-HSCT. IgG and IgM antibodies against T. gondii were determined in 78 patients before HSCT, as well as in their donors. T. gondii DNA post-transplant proved to be positive in 13% of blood specimens, 9% of cerebrospinal liquor samples, 11% of bronchoalveolar cell lavages, and in 5% of urine sediments. In adolescent patients (10 to 14 years old), an increased prevalence of T. gondii was found in patients who received myeloablative treatment (p = 0.01). When assessing posttransplant dynamics of T. gondii, we have revealed distinct increase in the pathogen excretion within 1st month after HSCT (p = 0.03). Finally, initial presence of IgG antibodies against T. gondii in the patients was associated with lower incidence of the pathogen reactivation post-transplant.A. B. ChukhlovinL. S. ZubarovskayaS. N. BondarenkoYu. A. EismontA. V. SemenovM. D. VladovskayaAreg A. TotolianB. V. AfanasyevSankt-Peterburg : NIIÈM imeni Pasteraarticlehematopoietic stem cell transplantationtoxoplasma gondiireactivationdna diagnosticsigg antibodiesInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 4, Iss 4, Pp 381-386 (2015)
institution	DOAJ
collection	DOAJ
language	RU
topic	hematopoietic stem cell transplantation toxoplasma gondii reactivation dna diagnostics igg antibodies Infectious and parasitic diseases RC109-216
spellingShingle	hematopoietic stem cell transplantation toxoplasma gondii reactivation dna diagnostics igg antibodies Infectious and parasitic diseases RC109-216 A. B. Chukhlovin L. S. Zubarovskaya S. N. Bondarenko Yu. A. Eismont A. V. Semenov M. D. Vladovskaya Areg A. Totolian B. V. Afanasyev ACTIVATION OF T. GONDII INFECTION AFTER ALLOGENEIC TRANSPLANTATION OF HEMATOPOIETIC STEM CELLS: DEPENDENCE ON TIME OF TRANSPLANTATION AND SEROLOGICAL STATUS OF THE PATIENTS
description	The article focuses on aspects of T. gondii reactivation/reinfection in patients undergoing allogeneic hematopoietic stem cell transplantation (alloHSCT). We have observed 297 patients who received conditioning therapy and allogeneic grafts due to different oncohematological or lymphoproliferative diseases (1 to 60 years old, at a mediane of 19 years). Conditioning regimens were either myeloablative (35%), or non-myeloablative (65%). DNA diagnostics of T. gondii was performed on a regular basis at 0 to 6 months post-HSCT. IgG and IgM antibodies against T. gondii were determined in 78 patients before HSCT, as well as in their donors. T. gondii DNA post-transplant proved to be positive in 13% of blood specimens, 9% of cerebrospinal liquor samples, 11% of bronchoalveolar cell lavages, and in 5% of urine sediments. In adolescent patients (10 to 14 years old), an increased prevalence of T. gondii was found in patients who received myeloablative treatment (p = 0.01). When assessing posttransplant dynamics of T. gondii, we have revealed distinct increase in the pathogen excretion within 1st month after HSCT (p = 0.03). Finally, initial presence of IgG antibodies against T. gondii in the patients was associated with lower incidence of the pathogen reactivation post-transplant.
format	article
author	A. B. Chukhlovin L. S. Zubarovskaya S. N. Bondarenko Yu. A. Eismont A. V. Semenov M. D. Vladovskaya Areg A. Totolian B. V. Afanasyev
author_facet	A. B. Chukhlovin L. S. Zubarovskaya S. N. Bondarenko Yu. A. Eismont A. V. Semenov M. D. Vladovskaya Areg A. Totolian B. V. Afanasyev
author_sort	A. B. Chukhlovin
title	ACTIVATION OF T. GONDII INFECTION AFTER ALLOGENEIC TRANSPLANTATION OF HEMATOPOIETIC STEM CELLS: DEPENDENCE ON TIME OF TRANSPLANTATION AND SEROLOGICAL STATUS OF THE PATIENTS
title_short	ACTIVATION OF T. GONDII INFECTION AFTER ALLOGENEIC TRANSPLANTATION OF HEMATOPOIETIC STEM CELLS: DEPENDENCE ON TIME OF TRANSPLANTATION AND SEROLOGICAL STATUS OF THE PATIENTS
title_full	ACTIVATION OF T. GONDII INFECTION AFTER ALLOGENEIC TRANSPLANTATION OF HEMATOPOIETIC STEM CELLS: DEPENDENCE ON TIME OF TRANSPLANTATION AND SEROLOGICAL STATUS OF THE PATIENTS
title_fullStr	ACTIVATION OF T. GONDII INFECTION AFTER ALLOGENEIC TRANSPLANTATION OF HEMATOPOIETIC STEM CELLS: DEPENDENCE ON TIME OF TRANSPLANTATION AND SEROLOGICAL STATUS OF THE PATIENTS
title_full_unstemmed	ACTIVATION OF T. GONDII INFECTION AFTER ALLOGENEIC TRANSPLANTATION OF HEMATOPOIETIC STEM CELLS: DEPENDENCE ON TIME OF TRANSPLANTATION AND SEROLOGICAL STATUS OF THE PATIENTS
title_sort	activation of t. gondii infection after allogeneic transplantation of hematopoietic stem cells: dependence on time of transplantation and serological status of the patients
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2015
url	https://doaj.org/article/1434dd6499444942a9a35bdd0d2972bc
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ACTIVATION OF T. GONDII INFECTION AFTER ALLOGENEIC TRANSPLANTATION OF HEMATOPOIETIC STEM CELLS: DEPENDENCE ON TIME OF TRANSPLANTATION AND SEROLOGICAL STATUS OF THE PATIENTS

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