Effects of Soy Isoflavones, Resistant Starch and Antibiotics on Polycystic Ovary Syndrome (PCOS)-Like Features in Letrozole-Treated Rats

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive-aged women. Recently, various dietary interventions have been used extensively as a novel therapy against PCOS. In the present study, we show that soy isoflavone metabolites and resistant starch, together with gut...

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Autores principales:	Geethika S. G. Liyanage, Ryo Inoue, Mina Fujitani, Tomoko Ishijima, Taisei Shibutani, Keiko Abe, Taro Kishida, Shinji Okada
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	PCOS soy isoflavones resistant starch antibiotics gut microbiota Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/14396eea581a466fbc1137b6af0c8520
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spelling	oai:doaj.org-article:14396eea581a466fbc1137b6af0c85202021-11-25T18:33:49ZEffects of Soy Isoflavones, Resistant Starch and Antibiotics on Polycystic Ovary Syndrome (PCOS)-Like Features in Letrozole-Treated Rats10.3390/nu131137592072-6643https://doaj.org/article/14396eea581a466fbc1137b6af0c85202021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3759https://doaj.org/toc/2072-6643Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive-aged women. Recently, various dietary interventions have been used extensively as a novel therapy against PCOS. In the present study, we show that soy isoflavone metabolites and resistant starch, together with gut microbiota modulations, were successful in decreasing the severity of PCOS-like reproductive features while increasing the expression of gut barrier markers and butyric acid in the gut. In the letrozole-induced PCOS model rats, the intake of both 0.05% soy isoflavones and 11% resistant starch, even with letrozole treatment, reduced the severity of menstrual irregularity and polycystic ovaries with a high concentration of soy isoflavones and equol in plasma. Antibiotic cocktail treatment suppressed soy isoflavone metabolism in the gut and showed no considerable effects on reducing the PCOS-like symptoms. The mRNA expression level of occludin significantly increased with soy isoflavone and resistant starch combined treatment. Bacterial genera such as <i>Blautia</i>, <i>Dorea</i> and <i>Clostridium</i> were positively correlated with menstrual irregularity under resistant starch intake. Moreover, the concentration of butyric acid was elevated by resistant starch intake. In conclusion, we propose that both dietary interventions and gut microbiota modulations could be effectively used in reducing the severity of PCOS reproductive features.Geethika S. G. LiyanageRyo InoueMina FujitaniTomoko IshijimaTaisei ShibutaniKeiko AbeTaro KishidaShinji OkadaMDPI AGarticlePCOSsoy isoflavonesresistant starchantibioticsgut microbiotaNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3759, p 3759 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	PCOS soy isoflavones resistant starch antibiotics gut microbiota Nutrition. Foods and food supply TX341-641
spellingShingle	PCOS soy isoflavones resistant starch antibiotics gut microbiota Nutrition. Foods and food supply TX341-641 Geethika S. G. Liyanage Ryo Inoue Mina Fujitani Tomoko Ishijima Taisei Shibutani Keiko Abe Taro Kishida Shinji Okada Effects of Soy Isoflavones, Resistant Starch and Antibiotics on Polycystic Ovary Syndrome (PCOS)-Like Features in Letrozole-Treated Rats
description	Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive-aged women. Recently, various dietary interventions have been used extensively as a novel therapy against PCOS. In the present study, we show that soy isoflavone metabolites and resistant starch, together with gut microbiota modulations, were successful in decreasing the severity of PCOS-like reproductive features while increasing the expression of gut barrier markers and butyric acid in the gut. In the letrozole-induced PCOS model rats, the intake of both 0.05% soy isoflavones and 11% resistant starch, even with letrozole treatment, reduced the severity of menstrual irregularity and polycystic ovaries with a high concentration of soy isoflavones and equol in plasma. Antibiotic cocktail treatment suppressed soy isoflavone metabolism in the gut and showed no considerable effects on reducing the PCOS-like symptoms. The mRNA expression level of occludin significantly increased with soy isoflavone and resistant starch combined treatment. Bacterial genera such as <i>Blautia</i>, <i>Dorea</i> and <i>Clostridium</i> were positively correlated with menstrual irregularity under resistant starch intake. Moreover, the concentration of butyric acid was elevated by resistant starch intake. In conclusion, we propose that both dietary interventions and gut microbiota modulations could be effectively used in reducing the severity of PCOS reproductive features.
format	article
author	Geethika S. G. Liyanage Ryo Inoue Mina Fujitani Tomoko Ishijima Taisei Shibutani Keiko Abe Taro Kishida Shinji Okada
author_facet	Geethika S. G. Liyanage Ryo Inoue Mina Fujitani Tomoko Ishijima Taisei Shibutani Keiko Abe Taro Kishida Shinji Okada
author_sort	Geethika S. G. Liyanage
title	Effects of Soy Isoflavones, Resistant Starch and Antibiotics on Polycystic Ovary Syndrome (PCOS)-Like Features in Letrozole-Treated Rats
title_short	Effects of Soy Isoflavones, Resistant Starch and Antibiotics on Polycystic Ovary Syndrome (PCOS)-Like Features in Letrozole-Treated Rats
title_full	Effects of Soy Isoflavones, Resistant Starch and Antibiotics on Polycystic Ovary Syndrome (PCOS)-Like Features in Letrozole-Treated Rats
title_fullStr	Effects of Soy Isoflavones, Resistant Starch and Antibiotics on Polycystic Ovary Syndrome (PCOS)-Like Features in Letrozole-Treated Rats
title_full_unstemmed	Effects of Soy Isoflavones, Resistant Starch and Antibiotics on Polycystic Ovary Syndrome (PCOS)-Like Features in Letrozole-Treated Rats
title_sort	effects of soy isoflavones, resistant starch and antibiotics on polycystic ovary syndrome (pcos)-like features in letrozole-treated rats
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/14396eea581a466fbc1137b6af0c8520
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Effects of Soy Isoflavones, Resistant Starch and Antibiotics on Polycystic Ovary Syndrome (PCOS)-Like Features in Letrozole-Treated Rats

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