Structural characterization of a novel human adeno-associated virus capsid with neurotropic properties

Adeno-associated viruses (AAVs) are vehicles for gene therapy in humans, but currently only a limited amount of AAV serotypes is available. Here, the authors identify a novel AAV, AAVv66, and demonstrate enhanced production yields, virion stability, and CNS transduction compared to the clinically ap...

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Autores principales:	Hung-Lun Hsu, Alexander Brown, Anna B. Loveland, Anoushka Lotun, Meiyu Xu, Li Luo, Guangchao Xu, Jia Li, Lingzhi Ren, Qin Su, Dominic J. Gessler, Yuquan Wei, Phillip W. L. Tai, Andrei A. Korostelev, Guangping Gao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/143cfb7a1596401ea3955f040a832c0f
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spelling	oai:doaj.org-article:143cfb7a1596401ea3955f040a832c0f2021-12-02T18:18:46ZStructural characterization of a novel human adeno-associated virus capsid with neurotropic properties10.1038/s41467-020-17047-12041-1723https://doaj.org/article/143cfb7a1596401ea3955f040a832c0f2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17047-1https://doaj.org/toc/2041-1723Adeno-associated viruses (AAVs) are vehicles for gene therapy in humans, but currently only a limited amount of AAV serotypes is available. Here, the authors identify a novel AAV, AAVv66, and demonstrate enhanced production yields, virion stability, and CNS transduction compared to the clinically approved serotype AAV2.Hung-Lun HsuAlexander BrownAnna B. LovelandAnoushka LotunMeiyu XuLi LuoGuangchao XuJia LiLingzhi RenQin SuDominic J. GesslerYuquan WeiPhillip W. L. TaiAndrei A. KorostelevGuangping GaoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hung-Lun Hsu Alexander Brown Anna B. Loveland Anoushka Lotun Meiyu Xu Li Luo Guangchao Xu Jia Li Lingzhi Ren Qin Su Dominic J. Gessler Yuquan Wei Phillip W. L. Tai Andrei A. Korostelev Guangping Gao Structural characterization of a novel human adeno-associated virus capsid with neurotropic properties
description	Adeno-associated viruses (AAVs) are vehicles for gene therapy in humans, but currently only a limited amount of AAV serotypes is available. Here, the authors identify a novel AAV, AAVv66, and demonstrate enhanced production yields, virion stability, and CNS transduction compared to the clinically approved serotype AAV2.
format	article
author	Hung-Lun Hsu Alexander Brown Anna B. Loveland Anoushka Lotun Meiyu Xu Li Luo Guangchao Xu Jia Li Lingzhi Ren Qin Su Dominic J. Gessler Yuquan Wei Phillip W. L. Tai Andrei A. Korostelev Guangping Gao
author_facet	Hung-Lun Hsu Alexander Brown Anna B. Loveland Anoushka Lotun Meiyu Xu Li Luo Guangchao Xu Jia Li Lingzhi Ren Qin Su Dominic J. Gessler Yuquan Wei Phillip W. L. Tai Andrei A. Korostelev Guangping Gao
author_sort	Hung-Lun Hsu
title	Structural characterization of a novel human adeno-associated virus capsid with neurotropic properties
title_short	Structural characterization of a novel human adeno-associated virus capsid with neurotropic properties
title_full	Structural characterization of a novel human adeno-associated virus capsid with neurotropic properties
title_fullStr	Structural characterization of a novel human adeno-associated virus capsid with neurotropic properties
title_full_unstemmed	Structural characterization of a novel human adeno-associated virus capsid with neurotropic properties
title_sort	structural characterization of a novel human adeno-associated virus capsid with neurotropic properties
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/143cfb7a1596401ea3955f040a832c0f
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Structural characterization of a novel human adeno-associated virus capsid with neurotropic properties

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