Association of Tumor Hydroxyindole O-Methyltransferase and Serum 5-Methoxytryptophan with Long-Term Survival of Hepatocellular Carcinoma

5-methoxytryptophan (5-MTP) is a recently discovered tryptophan (Trp) metabolite with anti-inflammatory and tumor-suppressing actions. Its synthesis is catalyzed by hydroxyindole O-methyltransferase (HIOMT). HIOMT levels were reported to be decreased in some patients with colorectal, pancreatic and...

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Autores principales:	Bor-Sheng Ko, Shu-Man Liang, Tzu-Ching Chang, Jing-Yiing Wu, Po-Hsun Lee, Yu-Juei Hsu, Cheng-Chin Kuo, Jun-Yang Liou, Kenneth K. Wu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hepatocellular carcinoma 5-methoxytryptophan hydroxyindole O-methyltransferase kynurenine biomarker Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/143ff198450c463e8f789de7ad4104c8
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spelling	oai:doaj.org-article:143ff198450c463e8f789de7ad4104c82021-11-11T15:28:02ZAssociation of Tumor Hydroxyindole O-Methyltransferase and Serum 5-Methoxytryptophan with Long-Term Survival of Hepatocellular Carcinoma10.3390/cancers132153112072-6694https://doaj.org/article/143ff198450c463e8f789de7ad4104c82021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5311https://doaj.org/toc/2072-66945-methoxytryptophan (5-MTP) is a recently discovered tryptophan (Trp) metabolite with anti-inflammatory and tumor-suppressing actions. Its synthesis is catalyzed by hydroxyindole O-methyltransferase (HIOMT). HIOMT levels were reported to be decreased in some patients with colorectal, pancreatic and breast cancer. It is unclear whether tissue HIOMT levels is altered in hepatocellular carcinoma (HCC). It is also unclear whether serum 5-MTP concentration is influenced by HCC. In this study, 150 HCC and adjacent normal liver tissues and serum samples were obtained from the HCC biobank established by a prospective multicenter study. Serum samples from 47 healthy subjects were included as a reference. HIOMT mRNA was measured by real time PCR. Serum 5-MTP and selected Trp metabolites were analyzed by quantitative LC-MS. HCC tissue HIOMT mRNA levels adjusted for adjacent normal tissue HIOMT mRNA levels was associated with overall and relapse-free (RF) survival. Combined serum 5-MTP or tissue HIOMT mRNA and serum kynurenine (Kyn) analysis predicted prolonged overall and RF survival following liver resection. A high serum 5-MTP or tissue HIOMT mRNA and low serum Kyn is associated with long-term survival. In conclusion, tumor tissue HIOMT mRNA and serum 5-MTP are potential biomarkers of HCC, especially when analyzed in combination with serum Kyn.Bor-Sheng KoShu-Man LiangTzu-Ching ChangJing-Yiing WuPo-Hsun LeeYu-Juei HsuCheng-Chin KuoJun-Yang LiouKenneth K. WuMDPI AGarticlehepatocellular carcinoma5-methoxytryptophanhydroxyindole O-methyltransferasekynureninebiomarkerNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5311, p 5311 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hepatocellular carcinoma 5-methoxytryptophan hydroxyindole O-methyltransferase kynurenine biomarker Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	hepatocellular carcinoma 5-methoxytryptophan hydroxyindole O-methyltransferase kynurenine biomarker Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Bor-Sheng Ko Shu-Man Liang Tzu-Ching Chang Jing-Yiing Wu Po-Hsun Lee Yu-Juei Hsu Cheng-Chin Kuo Jun-Yang Liou Kenneth K. Wu Association of Tumor Hydroxyindole O-Methyltransferase and Serum 5-Methoxytryptophan with Long-Term Survival of Hepatocellular Carcinoma
description	5-methoxytryptophan (5-MTP) is a recently discovered tryptophan (Trp) metabolite with anti-inflammatory and tumor-suppressing actions. Its synthesis is catalyzed by hydroxyindole O-methyltransferase (HIOMT). HIOMT levels were reported to be decreased in some patients with colorectal, pancreatic and breast cancer. It is unclear whether tissue HIOMT levels is altered in hepatocellular carcinoma (HCC). It is also unclear whether serum 5-MTP concentration is influenced by HCC. In this study, 150 HCC and adjacent normal liver tissues and serum samples were obtained from the HCC biobank established by a prospective multicenter study. Serum samples from 47 healthy subjects were included as a reference. HIOMT mRNA was measured by real time PCR. Serum 5-MTP and selected Trp metabolites were analyzed by quantitative LC-MS. HCC tissue HIOMT mRNA levels adjusted for adjacent normal tissue HIOMT mRNA levels was associated with overall and relapse-free (RF) survival. Combined serum 5-MTP or tissue HIOMT mRNA and serum kynurenine (Kyn) analysis predicted prolonged overall and RF survival following liver resection. A high serum 5-MTP or tissue HIOMT mRNA and low serum Kyn is associated with long-term survival. In conclusion, tumor tissue HIOMT mRNA and serum 5-MTP are potential biomarkers of HCC, especially when analyzed in combination with serum Kyn.
format	article
author	Bor-Sheng Ko Shu-Man Liang Tzu-Ching Chang Jing-Yiing Wu Po-Hsun Lee Yu-Juei Hsu Cheng-Chin Kuo Jun-Yang Liou Kenneth K. Wu
author_facet	Bor-Sheng Ko Shu-Man Liang Tzu-Ching Chang Jing-Yiing Wu Po-Hsun Lee Yu-Juei Hsu Cheng-Chin Kuo Jun-Yang Liou Kenneth K. Wu
author_sort	Bor-Sheng Ko
title	Association of Tumor Hydroxyindole O-Methyltransferase and Serum 5-Methoxytryptophan with Long-Term Survival of Hepatocellular Carcinoma
title_short	Association of Tumor Hydroxyindole O-Methyltransferase and Serum 5-Methoxytryptophan with Long-Term Survival of Hepatocellular Carcinoma
title_full	Association of Tumor Hydroxyindole O-Methyltransferase and Serum 5-Methoxytryptophan with Long-Term Survival of Hepatocellular Carcinoma
title_fullStr	Association of Tumor Hydroxyindole O-Methyltransferase and Serum 5-Methoxytryptophan with Long-Term Survival of Hepatocellular Carcinoma
title_full_unstemmed	Association of Tumor Hydroxyindole O-Methyltransferase and Serum 5-Methoxytryptophan with Long-Term Survival of Hepatocellular Carcinoma
title_sort	association of tumor hydroxyindole o-methyltransferase and serum 5-methoxytryptophan with long-term survival of hepatocellular carcinoma
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/143ff198450c463e8f789de7ad4104c8
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Association of Tumor Hydroxyindole O-Methyltransferase and Serum 5-Methoxytryptophan with Long-Term Survival of Hepatocellular Carcinoma

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