Self-patterning of rostral-caudal neuroectoderm requires dual role of Fgf signaling for localized Wnt antagonism

Self-patterning of rostral-caudal neuroectoderm requires dual role of Fgf signaling for localized Wnt antagonism

The neuroectoderm is patterned in a rostral-caudal axis in the embryo but how positional information is interpreted, is unclear. Here, the authors show that in mouse 3D embryonic stem cell cultures, there is self-patterning that depends on sequential activation of localised Fgf then Wnt signalling.

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Autores principales: Nozomu Takata, Eriko Sakakura, Mototsugu Eiraku, Takeya Kasukawa, Yoshiki Sasai
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/1440dcdddfed461ca36cc2598fcdb630
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spelling oai:doaj.org-article:1440dcdddfed461ca36cc2598fcdb6302021-12-02T14:40:26ZSelf-patterning of rostral-caudal neuroectoderm requires dual role of Fgf signaling for localized Wnt antagonism10.1038/s41467-017-01105-22041-1723https://doaj.org/article/1440dcdddfed461ca36cc2598fcdb6302017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01105-2https://doaj.org/toc/2041-1723The neuroectoderm is patterned in a rostral-caudal axis in the embryo but how positional information is interpreted, is unclear. Here, the authors show that in mouse 3D embryonic stem cell cultures, there is self-patterning that depends on sequential activation of localised Fgf then Wnt signalling.Nozomu TakataEriko SakakuraMototsugu EirakuTakeya KasukawaYoshiki SasaiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Nozomu Takata
Eriko Sakakura
Mototsugu Eiraku
Takeya Kasukawa
Yoshiki Sasai
Self-patterning of rostral-caudal neuroectoderm requires dual role of Fgf signaling for localized Wnt antagonism
description The neuroectoderm is patterned in a rostral-caudal axis in the embryo but how positional information is interpreted, is unclear. Here, the authors show that in mouse 3D embryonic stem cell cultures, there is self-patterning that depends on sequential activation of localised Fgf then Wnt signalling.
format article
author Nozomu Takata
Eriko Sakakura
Mototsugu Eiraku
Takeya Kasukawa
Yoshiki Sasai
author_facet Nozomu Takata
Eriko Sakakura
Mototsugu Eiraku
Takeya Kasukawa
Yoshiki Sasai
author_sort Nozomu Takata
title Self-patterning of rostral-caudal neuroectoderm requires dual role of Fgf signaling for localized Wnt antagonism
title_short Self-patterning of rostral-caudal neuroectoderm requires dual role of Fgf signaling for localized Wnt antagonism
title_full Self-patterning of rostral-caudal neuroectoderm requires dual role of Fgf signaling for localized Wnt antagonism
title_fullStr Self-patterning of rostral-caudal neuroectoderm requires dual role of Fgf signaling for localized Wnt antagonism
title_full_unstemmed Self-patterning of rostral-caudal neuroectoderm requires dual role of Fgf signaling for localized Wnt antagonism
title_sort self-patterning of rostral-caudal neuroectoderm requires dual role of fgf signaling for localized wnt antagonism
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/1440dcdddfed461ca36cc2598fcdb630
work_keys_str_mv AT nozomutakata selfpatterningofrostralcaudalneuroectodermrequiresdualroleoffgfsignalingforlocalizedwntantagonism
AT erikosakakura selfpatterningofrostralcaudalneuroectodermrequiresdualroleoffgfsignalingforlocalizedwntantagonism
AT mototsugueiraku selfpatterningofrostralcaudalneuroectodermrequiresdualroleoffgfsignalingforlocalizedwntantagonism
AT takeyakasukawa selfpatterningofrostralcaudalneuroectodermrequiresdualroleoffgfsignalingforlocalizedwntantagonism
AT yoshikisasai selfpatterningofrostralcaudalneuroectodermrequiresdualroleoffgfsignalingforlocalizedwntantagonism
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