A salvage pathway maintains highly functional respiratory complex I
Maintenance and quality control of the mitochondrial respiratory chain complexes responsible for bulk energy production are unclear. Here, the authors show that the mitochondrial protease ClpXP is required for the rapid turnover of the core N-module of respiratory complex I, which happens independen...
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Nature Portfolio
2020
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oai:doaj.org-article:1441c467d7c84761ba914e66d3b9d5a72021-12-02T14:42:13ZA salvage pathway maintains highly functional respiratory complex I10.1038/s41467-020-15467-72041-1723https://doaj.org/article/1441c467d7c84761ba914e66d3b9d5a72020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15467-7https://doaj.org/toc/2041-1723Maintenance and quality control of the mitochondrial respiratory chain complexes responsible for bulk energy production are unclear. Here, the authors show that the mitochondrial protease ClpXP is required for the rapid turnover of the core N-module of respiratory complex I, which happens independently of other modules in the complex.Karolina SzczepanowskaKatharina SenftJuliana HeidlerMarija HerholzAlexandra KukatMichaela Nicole HöhneEduard HofsetzChristina BeckerSophie KasparHeiko GieseKlaus ZwickerSergio Guerrero-CastilloLinda BaumannJohanna KauppilaAnastasia RumyantsevaStefan MüllerChristian K. FreseUlrich BrandtJan RiemerIlka WittigAleksandra TrifunovicNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Karolina Szczepanowska Katharina Senft Juliana Heidler Marija Herholz Alexandra Kukat Michaela Nicole Höhne Eduard Hofsetz Christina Becker Sophie Kaspar Heiko Giese Klaus Zwicker Sergio Guerrero-Castillo Linda Baumann Johanna Kauppila Anastasia Rumyantseva Stefan Müller Christian K. Frese Ulrich Brandt Jan Riemer Ilka Wittig Aleksandra Trifunovic A salvage pathway maintains highly functional respiratory complex I |
| description |
Maintenance and quality control of the mitochondrial respiratory chain complexes responsible for bulk energy production are unclear. Here, the authors show that the mitochondrial protease ClpXP is required for the rapid turnover of the core N-module of respiratory complex I, which happens independently of other modules in the complex. |
| format |
article |
| author |
Karolina Szczepanowska Katharina Senft Juliana Heidler Marija Herholz Alexandra Kukat Michaela Nicole Höhne Eduard Hofsetz Christina Becker Sophie Kaspar Heiko Giese Klaus Zwicker Sergio Guerrero-Castillo Linda Baumann Johanna Kauppila Anastasia Rumyantseva Stefan Müller Christian K. Frese Ulrich Brandt Jan Riemer Ilka Wittig Aleksandra Trifunovic |
| author_facet |
Karolina Szczepanowska Katharina Senft Juliana Heidler Marija Herholz Alexandra Kukat Michaela Nicole Höhne Eduard Hofsetz Christina Becker Sophie Kaspar Heiko Giese Klaus Zwicker Sergio Guerrero-Castillo Linda Baumann Johanna Kauppila Anastasia Rumyantseva Stefan Müller Christian K. Frese Ulrich Brandt Jan Riemer Ilka Wittig Aleksandra Trifunovic |
| author_sort |
Karolina Szczepanowska |
| title |
A salvage pathway maintains highly functional respiratory complex I |
| title_short |
A salvage pathway maintains highly functional respiratory complex I |
| title_full |
A salvage pathway maintains highly functional respiratory complex I |
| title_fullStr |
A salvage pathway maintains highly functional respiratory complex I |
| title_full_unstemmed |
A salvage pathway maintains highly functional respiratory complex I |
| title_sort |
salvage pathway maintains highly functional respiratory complex i |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/1441c467d7c84761ba914e66d3b9d5a7 |
| work_keys_str_mv |
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| _version_ |
1718389736259715072 |