Altered static and dynamic functional network connectivity in post-traumatic headache

Abstract Background Post-traumatic headache (PTH) is a very common symptom following mild traumatic brain injury (mTBI), yet much remains unknown about the underlying pathophysiological mechanisms of PTH. Neuroimaging studies suggest that aberrant functional network connectivity (FNC) may be an impo...

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Autores principales:	Fengfang Li, Liyan Lu, Song’an Shang, Huiyou Chen, Peng Wang, Vijaya Prakash Muthaiah, Xindao Yin, Yu-Chen Chen
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Post-traumatic headache Mild traumatic brain injury Functional magnetic resonance imaging Functional network connectivity Medicine R
Acceso en línea:	https://doaj.org/article/1442a5b3399d43eab6a84e6bef04cb60
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spelling	oai:doaj.org-article:1442a5b3399d43eab6a84e6bef04cb602021-11-14T12:37:31ZAltered static and dynamic functional network connectivity in post-traumatic headache10.1186/s10194-021-01348-x1129-23691129-2377https://doaj.org/article/1442a5b3399d43eab6a84e6bef04cb602021-11-01T00:00:00Zhttps://doi.org/10.1186/s10194-021-01348-xhttps://doaj.org/toc/1129-2369https://doaj.org/toc/1129-2377Abstract Background Post-traumatic headache (PTH) is a very common symptom following mild traumatic brain injury (mTBI), yet much remains unknown about the underlying pathophysiological mechanisms of PTH. Neuroimaging studies suggest that aberrant functional network connectivity (FNC) may be an important factor in pain disorders. The present study aimed to investigate the functional characteristics of static FNC (sFNC) and dynamic FNC (dFNC) in mTBI patients with PTH. Methods With Institutional Review Board (IRB) approval, we prospectively recruited 50 mTBI patients with PTH, who were diagnosed with ICHD-3 beta diagnostic criteria and 39 mTBI without PTH who were well matched for age, gender and education. Resting-state functional magnetic resonance imaging (fMRI) scanning (3.0 T, Philips Medical Systems, Netherlands), Montreal Cognitive Assessment (MoCA) and headache symptom measurement (headache frequency and headache intensity) were performed. The resting-state fMRI sequence took 8 min and 10 s. Independent component analysis and sliding window method were applied to examine the FNC on the basis of nine resting-state networks, namely, default mode network (DMN), sensorimotor network (SMN), executive control network (ECN), auditory network (AuN), attention network (AN), salience network (SN), visual network (VN), and cerebellum network (CN). The differences in sFNC and dFNC were determined and correlated with clinical variables using Pearson rank correlation. Results For sFNC, compared with mTBI patients without PTH, mTB with PTH group showed four altered interactions, including decreased interactions in SN-SMN and VN-DMN pairs, increased sFNC in SN-ECN and SMN-DMN pairs. For dFNC, significant group differences were found in State 2, including increased connectivity alteration in the DMN with CN, DMN with SMN, and AuN with CN. Significant reduced connectivity changes in the DMN with VN was found in State 4. Furthermore, the number of transitions (r=0.394, p=0.005) between states was positively associated with headache frequency. Additionally, dwell time (r=-0.320, p=0.025) in State 1 was negatively correlated with MoCA score. Conclusions MTBI patients with PTH are characterized with altered sFNC and dFNC, which could provide new perspective to understand the neuropathological mechanism underlying the PTH to determine more appropriate management, and may be a useful imaging biomarker for identifying and predicting mTBI with PTH.Fengfang LiLiyan LuSong’an ShangHuiyou ChenPeng WangVijaya Prakash MuthaiahXindao YinYu-Chen ChenBMCarticlePost-traumatic headacheMild traumatic brain injuryFunctional magnetic resonance imagingFunctional network connectivityMedicineRENThe Journal of Headache and Pain, Vol 22, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Post-traumatic headache Mild traumatic brain injury Functional magnetic resonance imaging Functional network connectivity Medicine R
spellingShingle	Post-traumatic headache Mild traumatic brain injury Functional magnetic resonance imaging Functional network connectivity Medicine R Fengfang Li Liyan Lu Song’an Shang Huiyou Chen Peng Wang Vijaya Prakash Muthaiah Xindao Yin Yu-Chen Chen Altered static and dynamic functional network connectivity in post-traumatic headache
description	Abstract Background Post-traumatic headache (PTH) is a very common symptom following mild traumatic brain injury (mTBI), yet much remains unknown about the underlying pathophysiological mechanisms of PTH. Neuroimaging studies suggest that aberrant functional network connectivity (FNC) may be an important factor in pain disorders. The present study aimed to investigate the functional characteristics of static FNC (sFNC) and dynamic FNC (dFNC) in mTBI patients with PTH. Methods With Institutional Review Board (IRB) approval, we prospectively recruited 50 mTBI patients with PTH, who were diagnosed with ICHD-3 beta diagnostic criteria and 39 mTBI without PTH who were well matched for age, gender and education. Resting-state functional magnetic resonance imaging (fMRI) scanning (3.0 T, Philips Medical Systems, Netherlands), Montreal Cognitive Assessment (MoCA) and headache symptom measurement (headache frequency and headache intensity) were performed. The resting-state fMRI sequence took 8 min and 10 s. Independent component analysis and sliding window method were applied to examine the FNC on the basis of nine resting-state networks, namely, default mode network (DMN), sensorimotor network (SMN), executive control network (ECN), auditory network (AuN), attention network (AN), salience network (SN), visual network (VN), and cerebellum network (CN). The differences in sFNC and dFNC were determined and correlated with clinical variables using Pearson rank correlation. Results For sFNC, compared with mTBI patients without PTH, mTB with PTH group showed four altered interactions, including decreased interactions in SN-SMN and VN-DMN pairs, increased sFNC in SN-ECN and SMN-DMN pairs. For dFNC, significant group differences were found in State 2, including increased connectivity alteration in the DMN with CN, DMN with SMN, and AuN with CN. Significant reduced connectivity changes in the DMN with VN was found in State 4. Furthermore, the number of transitions (r=0.394, p=0.005) between states was positively associated with headache frequency. Additionally, dwell time (r=-0.320, p=0.025) in State 1 was negatively correlated with MoCA score. Conclusions MTBI patients with PTH are characterized with altered sFNC and dFNC, which could provide new perspective to understand the neuropathological mechanism underlying the PTH to determine more appropriate management, and may be a useful imaging biomarker for identifying and predicting mTBI with PTH.
format	article
author	Fengfang Li Liyan Lu Song’an Shang Huiyou Chen Peng Wang Vijaya Prakash Muthaiah Xindao Yin Yu-Chen Chen
author_facet	Fengfang Li Liyan Lu Song’an Shang Huiyou Chen Peng Wang Vijaya Prakash Muthaiah Xindao Yin Yu-Chen Chen
author_sort	Fengfang Li
title	Altered static and dynamic functional network connectivity in post-traumatic headache
title_short	Altered static and dynamic functional network connectivity in post-traumatic headache
title_full	Altered static and dynamic functional network connectivity in post-traumatic headache
title_fullStr	Altered static and dynamic functional network connectivity in post-traumatic headache
title_full_unstemmed	Altered static and dynamic functional network connectivity in post-traumatic headache
title_sort	altered static and dynamic functional network connectivity in post-traumatic headache
publisher	BMC
publishDate	2021
url	https://doaj.org/article/1442a5b3399d43eab6a84e6bef04cb60
work_keys_str_mv	AT fengfangli alteredstaticanddynamicfunctionalnetworkconnectivityinposttraumaticheadache AT liyanlu alteredstaticanddynamicfunctionalnetworkconnectivityinposttraumaticheadache AT songanshang alteredstaticanddynamicfunctionalnetworkconnectivityinposttraumaticheadache AT huiyouchen alteredstaticanddynamicfunctionalnetworkconnectivityinposttraumaticheadache AT pengwang alteredstaticanddynamicfunctionalnetworkconnectivityinposttraumaticheadache AT vijayaprakashmuthaiah alteredstaticanddynamicfunctionalnetworkconnectivityinposttraumaticheadache AT xindaoyin alteredstaticanddynamicfunctionalnetworkconnectivityinposttraumaticheadache AT yuchenchen alteredstaticanddynamicfunctionalnetworkconnectivityinposttraumaticheadache
_version_	1718429090970599424

Altered static and dynamic functional network connectivity in post-traumatic headache

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