KCNQ channels regulate age-related memory impairment.

In humans KCNQ2/3 heteromeric channels form an M-current that acts as a brake on neuronal excitability, with mutations causing a form of epilepsy. The M-current has been shown to be a key regulator of neuronal plasticity underlying associative memory and ethanol response in mammals. Previous work ha...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sonia Cavaliere, Bilal R Malik, James J L Hodge
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1442a60120534175981982cfe0f069ed
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1442a60120534175981982cfe0f069ed
record_format	dspace
spelling	oai:doaj.org-article:1442a60120534175981982cfe0f069ed2021-11-18T07:47:29ZKCNQ channels regulate age-related memory impairment.1932-620310.1371/journal.pone.0062445https://doaj.org/article/1442a60120534175981982cfe0f069ed2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23638087/?tool=EBIhttps://doaj.org/toc/1932-6203In humans KCNQ2/3 heteromeric channels form an M-current that acts as a brake on neuronal excitability, with mutations causing a form of epilepsy. The M-current has been shown to be a key regulator of neuronal plasticity underlying associative memory and ethanol response in mammals. Previous work has shown that many of the molecules and plasticity mechanisms underlying changes in alcohol behaviour and addiction are shared with those of memory. We show that the single KCNQ channel in Drosophila (dKCNQ) when mutated show decrements in associative short- and long-term memory, with KCNQ function in the mushroom body α/βneurons being required for short-term memory. Ethanol disrupts memory in wildtype flies, but not in a KCNQ null mutant background suggesting KCNQ maybe a direct target of ethanol, the blockade of which interferes with the plasticity machinery required for memory formation. We show that as in humans, Drosophila display age-related memory impairment with the KCNQ mutant memory defect mimicking the effect of age on memory. Expression of KCNQ normally decreases in aging brains and KCNQ overexpression in the mushroom body neurons of KCNQ mutants restores age-related memory impairment. Therefore KCNQ is a central plasticity molecule that regulates age dependent memory impairment.Sonia CavaliereBilal R MalikJames J L HodgePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e62445 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sonia Cavaliere Bilal R Malik James J L Hodge KCNQ channels regulate age-related memory impairment.
description	In humans KCNQ2/3 heteromeric channels form an M-current that acts as a brake on neuronal excitability, with mutations causing a form of epilepsy. The M-current has been shown to be a key regulator of neuronal plasticity underlying associative memory and ethanol response in mammals. Previous work has shown that many of the molecules and plasticity mechanisms underlying changes in alcohol behaviour and addiction are shared with those of memory. We show that the single KCNQ channel in Drosophila (dKCNQ) when mutated show decrements in associative short- and long-term memory, with KCNQ function in the mushroom body α/βneurons being required for short-term memory. Ethanol disrupts memory in wildtype flies, but not in a KCNQ null mutant background suggesting KCNQ maybe a direct target of ethanol, the blockade of which interferes with the plasticity machinery required for memory formation. We show that as in humans, Drosophila display age-related memory impairment with the KCNQ mutant memory defect mimicking the effect of age on memory. Expression of KCNQ normally decreases in aging brains and KCNQ overexpression in the mushroom body neurons of KCNQ mutants restores age-related memory impairment. Therefore KCNQ is a central plasticity molecule that regulates age dependent memory impairment.
format	article
author	Sonia Cavaliere Bilal R Malik James J L Hodge
author_facet	Sonia Cavaliere Bilal R Malik James J L Hodge
author_sort	Sonia Cavaliere
title	KCNQ channels regulate age-related memory impairment.
title_short	KCNQ channels regulate age-related memory impairment.
title_full	KCNQ channels regulate age-related memory impairment.
title_fullStr	KCNQ channels regulate age-related memory impairment.
title_full_unstemmed	KCNQ channels regulate age-related memory impairment.
title_sort	kcnq channels regulate age-related memory impairment.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/1442a60120534175981982cfe0f069ed
work_keys_str_mv	AT soniacavaliere kcnqchannelsregulateagerelatedmemoryimpairment AT bilalrmalik kcnqchannelsregulateagerelatedmemoryimpairment AT jamesjlhodge kcnqchannelsregulateagerelatedmemoryimpairment
_version_	1718422955217649664

KCNQ channels regulate age-related memory impairment.

Ejemplares similares