Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis

TLX is a nuclear receptor essential for neural stem cell self-renewal and recently involved in glioblastoma development. In this study, the authors show that inhibition of TLX expression, achieved using a dendrimer nanovector-delivered siRNAs or viral vector-delivered shRNAs, reduces glioblastoma st...

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Autores principales:	Qi Cui, Su Yang, Peng Ye, E. Tian, Guoqiang Sun, Jiehua Zhou, Guihua Sun, Xiaoxuan Liu, Chao Chen, Kiyohito Murai, Chunnian Zhao, Krist T. Azizian, Lu Yang, Charles Warden, Xiwei Wu, Massimo D'Apuzzo, Christine Brown, Behnam Badie, Ling Peng, Arthur D. Riggs, John J. Rossi, Yanhong Shi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1442e58753a245f1a93ab4dce27c8c5f
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spelling	oai:doaj.org-article:1442e58753a245f1a93ab4dce27c8c5f2021-12-02T14:39:52ZDownregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis10.1038/ncomms106372041-1723https://doaj.org/article/1442e58753a245f1a93ab4dce27c8c5f2016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10637https://doaj.org/toc/2041-1723TLX is a nuclear receptor essential for neural stem cell self-renewal and recently involved in glioblastoma development. In this study, the authors show that inhibition of TLX expression, achieved using a dendrimer nanovector-delivered siRNAs or viral vector-delivered shRNAs, reduces glioblastoma stem cells self renewal and in vivotumour growth through activation of TET3.Qi CuiSu YangPeng YeE. TianGuoqiang SunJiehua ZhouGuihua SunXiaoxuan LiuChao ChenKiyohito MuraiChunnian ZhaoKrist T. AzizianLu YangCharles WardenXiwei WuMassimo D'ApuzzoChristine BrownBehnam BadieLing PengArthur D. RiggsJohn J. RossiYanhong ShiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qi Cui Su Yang Peng Ye E. Tian Guoqiang Sun Jiehua Zhou Guihua Sun Xiaoxuan Liu Chao Chen Kiyohito Murai Chunnian Zhao Krist T. Azizian Lu Yang Charles Warden Xiwei Wu Massimo D'Apuzzo Christine Brown Behnam Badie Ling Peng Arthur D. Riggs John J. Rossi Yanhong Shi Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis
description	TLX is a nuclear receptor essential for neural stem cell self-renewal and recently involved in glioblastoma development. In this study, the authors show that inhibition of TLX expression, achieved using a dendrimer nanovector-delivered siRNAs or viral vector-delivered shRNAs, reduces glioblastoma stem cells self renewal and in vivotumour growth through activation of TET3.
format	article
author	Qi Cui Su Yang Peng Ye E. Tian Guoqiang Sun Jiehua Zhou Guihua Sun Xiaoxuan Liu Chao Chen Kiyohito Murai Chunnian Zhao Krist T. Azizian Lu Yang Charles Warden Xiwei Wu Massimo D'Apuzzo Christine Brown Behnam Badie Ling Peng Arthur D. Riggs John J. Rossi Yanhong Shi
author_facet	Qi Cui Su Yang Peng Ye E. Tian Guoqiang Sun Jiehua Zhou Guihua Sun Xiaoxuan Liu Chao Chen Kiyohito Murai Chunnian Zhao Krist T. Azizian Lu Yang Charles Warden Xiwei Wu Massimo D'Apuzzo Christine Brown Behnam Badie Ling Peng Arthur D. Riggs John J. Rossi Yanhong Shi
author_sort	Qi Cui
title	Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis
title_short	Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis
title_full	Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis
title_fullStr	Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis
title_full_unstemmed	Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis
title_sort	downregulation of tlx induces tet3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/1442e58753a245f1a93ab4dce27c8c5f
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Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis

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