The role of microglia in multiple sclerosis
Chun Luo,1 Chongdong Jian,1 Yuhan Liao,1 Qi Huang,1 Yuejuan Wu,1 Xixia Liu,1 Donghua Zou,2 Yuan Wu1 1Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, 2Department of Neurology, The Fifth Affiliated Hospital of Guangxi Medical University and The First People&r...
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Dove Medical Press
2017
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oai:doaj.org-article:144969423d304ac3a810349dda76a1542021-12-02T09:41:06ZThe role of microglia in multiple sclerosis1178-2021https://doaj.org/article/144969423d304ac3a810349dda76a1542017-06-01T00:00:00Zhttps://www.dovepress.com/the-role-of-microglia-in-multiple-sclerosis-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Chun Luo,1 Chongdong Jian,1 Yuhan Liao,1 Qi Huang,1 Yuejuan Wu,1 Xixia Liu,1 Donghua Zou,2 Yuan Wu1 1Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, 2Department of Neurology, The Fifth Affiliated Hospital of Guangxi Medical University and The First People’s Hospital of Nanning, Nanning, People’s Republic of China Abstract: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). Microglia are the resident innate immune cells in the CNS; they play an important role in the processes of demyelination and remyelination in MS. Microglia can function as antigen-presenting cells and phagocytes. In the past, microglia were considered to be the same cell type as macrophages, and researchers have different opinions about the role of microglia in MS. This review focuses on the original classification of microglia and their role in the pathogenesis of MS. Moreover, we present a hypothetical model for the role of microglia in the pathogenesis of MS based on recent findings. Keywords: microglia, multiple sclerosis, macrophage, myelinLuo CJian CLiao YHuang QWu YLiu XZou DWu YDove Medical Pressarticlemicrogliamultiple sclerosismacrophagemyelincentral nervous systempathogenesisNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 1661-1667 (2017) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
microglia multiple sclerosis macrophage myelin central nervous system pathogenesis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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microglia multiple sclerosis macrophage myelin central nervous system pathogenesis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Luo C Jian C Liao Y Huang Q Wu Y Liu X Zou D Wu Y The role of microglia in multiple sclerosis |
| description |
Chun Luo,1 Chongdong Jian,1 Yuhan Liao,1 Qi Huang,1 Yuejuan Wu,1 Xixia Liu,1 Donghua Zou,2 Yuan Wu1 1Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, 2Department of Neurology, The Fifth Affiliated Hospital of Guangxi Medical University and The First People’s Hospital of Nanning, Nanning, People’s Republic of China Abstract: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). Microglia are the resident innate immune cells in the CNS; they play an important role in the processes of demyelination and remyelination in MS. Microglia can function as antigen-presenting cells and phagocytes. In the past, microglia were considered to be the same cell type as macrophages, and researchers have different opinions about the role of microglia in MS. This review focuses on the original classification of microglia and their role in the pathogenesis of MS. Moreover, we present a hypothetical model for the role of microglia in the pathogenesis of MS based on recent findings. Keywords: microglia, multiple sclerosis, macrophage, myelin |
| format |
article |
| author |
Luo C Jian C Liao Y Huang Q Wu Y Liu X Zou D Wu Y |
| author_facet |
Luo C Jian C Liao Y Huang Q Wu Y Liu X Zou D Wu Y |
| author_sort |
Luo C |
| title |
The role of microglia in multiple sclerosis |
| title_short |
The role of microglia in multiple sclerosis |
| title_full |
The role of microglia in multiple sclerosis |
| title_fullStr |
The role of microglia in multiple sclerosis |
| title_full_unstemmed |
The role of microglia in multiple sclerosis |
| title_sort |
role of microglia in multiple sclerosis |
| publisher |
Dove Medical Press |
| publishDate |
2017 |
| url |
https://doaj.org/article/144969423d304ac3a810349dda76a154 |
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