Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors

STING is an intracellular DNA sensor that can alter response to infection, but in the case of malaria it is unclear how parasite DNA in red blood cells (RBCs) reaches DNA sensors in immune cells. Here the authors show that STING in human monocytes can sense P. falciparum nucleic acids transported fr...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xavier Sisquella, Yifat Ofir-Birin, Matthew A. Pimentel, Lesley Cheng, Paula Abou Karam, Natália G. Sampaio, Jocelyn Sietsma Penington, Dympna Connolly, Tal Giladi, Benjamin J. Scicluna, Robyn A. Sharples, Andreea Waltmann, Dror Avni, Eli Schwartz, Louis Schofield, Ziv Porat, Diana S. Hansen, Anthony T. Papenfuss, Emily M. Eriksson, Motti Gerlic, Andrew F. Hill, Andrew G. Bowie, Neta Regev-Rudzki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/144b9d639c34432f83aff80548d8d525
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:144b9d639c34432f83aff80548d8d525
record_format	dspace
spelling	oai:doaj.org-article:144b9d639c34432f83aff80548d8d5252021-12-02T15:37:04ZMalaria parasite DNA-harbouring vesicles activate cytosolic immune sensors10.1038/s41467-017-02083-12041-1723https://doaj.org/article/144b9d639c34432f83aff80548d8d5252017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02083-1https://doaj.org/toc/2041-1723STING is an intracellular DNA sensor that can alter response to infection, but in the case of malaria it is unclear how parasite DNA in red blood cells (RBCs) reaches DNA sensors in immune cells. Here the authors show that STING in human monocytes can sense P. falciparum nucleic acids transported from infected RBCs via parasite extracellular vesicles.Xavier SisquellaYifat Ofir-BirinMatthew A. PimentelLesley ChengPaula Abou KaramNatália G. SampaioJocelyn Sietsma PeningtonDympna ConnollyTal GiladiBenjamin J. SciclunaRobyn A. SharplesAndreea WaltmannDror AvniEli SchwartzLouis SchofieldZiv PoratDiana S. HansenAnthony T. PapenfussEmily M. ErikssonMotti GerlicAndrew F. HillAndrew G. BowieNeta Regev-RudzkiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xavier Sisquella Yifat Ofir-Birin Matthew A. Pimentel Lesley Cheng Paula Abou Karam Natália G. Sampaio Jocelyn Sietsma Penington Dympna Connolly Tal Giladi Benjamin J. Scicluna Robyn A. Sharples Andreea Waltmann Dror Avni Eli Schwartz Louis Schofield Ziv Porat Diana S. Hansen Anthony T. Papenfuss Emily M. Eriksson Motti Gerlic Andrew F. Hill Andrew G. Bowie Neta Regev-Rudzki Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors
description	STING is an intracellular DNA sensor that can alter response to infection, but in the case of malaria it is unclear how parasite DNA in red blood cells (RBCs) reaches DNA sensors in immune cells. Here the authors show that STING in human monocytes can sense P. falciparum nucleic acids transported from infected RBCs via parasite extracellular vesicles.
format	article
author	Xavier Sisquella Yifat Ofir-Birin Matthew A. Pimentel Lesley Cheng Paula Abou Karam Natália G. Sampaio Jocelyn Sietsma Penington Dympna Connolly Tal Giladi Benjamin J. Scicluna Robyn A. Sharples Andreea Waltmann Dror Avni Eli Schwartz Louis Schofield Ziv Porat Diana S. Hansen Anthony T. Papenfuss Emily M. Eriksson Motti Gerlic Andrew F. Hill Andrew G. Bowie Neta Regev-Rudzki
author_facet	Xavier Sisquella Yifat Ofir-Birin Matthew A. Pimentel Lesley Cheng Paula Abou Karam Natália G. Sampaio Jocelyn Sietsma Penington Dympna Connolly Tal Giladi Benjamin J. Scicluna Robyn A. Sharples Andreea Waltmann Dror Avni Eli Schwartz Louis Schofield Ziv Porat Diana S. Hansen Anthony T. Papenfuss Emily M. Eriksson Motti Gerlic Andrew F. Hill Andrew G. Bowie Neta Regev-Rudzki
author_sort	Xavier Sisquella
title	Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors
title_short	Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors
title_full	Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors
title_fullStr	Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors
title_full_unstemmed	Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors
title_sort	malaria parasite dna-harbouring vesicles activate cytosolic immune sensors
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/144b9d639c34432f83aff80548d8d525
work_keys_str_mv	AT xaviersisquella malariaparasitednaharbouringvesiclesactivatecytosolicimmunesensors AT yifatofirbirin malariaparasitednaharbouringvesiclesactivatecytosolicimmunesensors AT matthewapimentel malariaparasitednaharbouringvesiclesactivatecytosolicimmunesensors AT lesleycheng malariaparasitednaharbouringvesiclesactivatecytosolicimmunesensors AT paulaaboukaram malariaparasitednaharbouringvesiclesactivatecytosolicimmunesensors AT nataliagsampaio malariaparasitednaharbouringvesiclesactivatecytosolicimmunesensors AT jocelynsietsmapenington malariaparasitednaharbouringvesiclesactivatecytosolicimmunesensors AT dympnaconnolly malariaparasitednaharbouringvesiclesactivatecytosolicimmunesensors AT talgiladi malariaparasitednaharbouringvesiclesactivatecytosolicimmunesensors AT benjaminjscicluna malariaparasitednaharbouringvesiclesactivatecytosolicimmunesensors AT robynasharples malariaparasitednaharbouringvesiclesactivatecytosolicimmunesensors AT andreeawaltmann malariaparasitednaharbouringvesiclesactivatecytosolicimmunesensors AT droravni malariaparasitednaharbouringvesiclesactivatecytosolicimmunesensors AT elischwartz malariaparasitednaharbouringvesiclesactivatecytosolicimmunesensors AT louisschofield malariaparasitednaharbouringvesiclesactivatecytosolicimmunesensors AT zivporat malariaparasitednaharbouringvesiclesactivatecytosolicimmunesensors AT dianashansen malariaparasitednaharbouringvesiclesactivatecytosolicimmunesensors AT anthonytpapenfuss malariaparasitednaharbouringvesiclesactivatecytosolicimmunesensors AT emilymeriksson malariaparasitednaharbouringvesiclesactivatecytosolicimmunesensors AT mottigerlic malariaparasitednaharbouringvesiclesactivatecytosolicimmunesensors AT andrewfhill malariaparasitednaharbouringvesiclesactivatecytosolicimmunesensors AT andrewgbowie malariaparasitednaharbouringvesiclesactivatecytosolicimmunesensors AT netaregevrudzki malariaparasitednaharbouringvesiclesactivatecytosolicimmunesensors
_version_	1718386216208957440

Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors

Ejemplares similares