Do Hippocampal Neurons Really Count for Comorbid Depression in Patients With Mesial Temporal Lobe Epilepsy and Hippocampal Sclerosis? A Histopathological Study
Depression is the most frequent psychiatric comorbidity seen in mesial temporal lobe epilepsy (MTLE) patients with hippocampal sclerosis (HS). Moreover, the HS is the most frequent pathological hallmark in MTLE-HS. Although there is a well-documented hippocampal volumetric reduction in imaging studi...
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oai:doaj.org-article:144fbe02300642a3854fae6c41b6c3182021-12-01T15:33:34ZDo Hippocampal Neurons Really Count for Comorbid Depression in Patients With Mesial Temporal Lobe Epilepsy and Hippocampal Sclerosis? A Histopathological Study1662-514510.3389/fnint.2021.747237https://doaj.org/article/144fbe02300642a3854fae6c41b6c3182021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnint.2021.747237/fullhttps://doaj.org/toc/1662-5145Depression is the most frequent psychiatric comorbidity seen in mesial temporal lobe epilepsy (MTLE) patients with hippocampal sclerosis (HS). Moreover, the HS is the most frequent pathological hallmark in MTLE-HS. Although there is a well-documented hippocampal volumetric reduction in imaging studies of patients with major depressive disorder, in epilepsy with comorbid depression, the true role of the hippocampus is not entirely understood. This study aimed to verify if patients with unilateral MTLE-HS and the co-occurrence of depression have differences in neuronal density of the hippocampal sectors CA1–CA4. For this purpose, we used a histopathological approach. This was a pioneering study with patients having both clinical disorders. However, we found no difference in hippocampal neuronal density when depression co-occurs in patients with epilepsy. In this series, CA1 had the lowest counting in both groups, and HS ILAE Type 1 was the most prevalent. More studies using histological assessments are needed to clarify the physiopathology of depression in MTLE-HS.Nathália Stela Visoná de FigueiredoAnaclara Prada JardimLenon MazettoJeana Torres Corso DuarteSandra Mara ComperNeide Barreira AlonsoMaria Helena da Silva NoffsCarla Alessandra ScorzaEsper Abrão CavalheiroRicardo Silva CentenoGerardo Maria de Araújo FilhoElza Márcia Targas YacubianFrontiers Media S.A.articlehistological evaluationdepressionmesial temporal epilepsyhippocampal sclerosis (HS)neuronal countNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENFrontiers in Integrative Neuroscience, Vol 15 (2021) |
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histological evaluation depression mesial temporal epilepsy hippocampal sclerosis (HS) neuronal count Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
spellingShingle |
histological evaluation depression mesial temporal epilepsy hippocampal sclerosis (HS) neuronal count Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Nathália Stela Visoná de Figueiredo Anaclara Prada Jardim Lenon Mazetto Jeana Torres Corso Duarte Sandra Mara Comper Neide Barreira Alonso Maria Helena da Silva Noffs Carla Alessandra Scorza Esper Abrão Cavalheiro Ricardo Silva Centeno Gerardo Maria de Araújo Filho Elza Márcia Targas Yacubian Do Hippocampal Neurons Really Count for Comorbid Depression in Patients With Mesial Temporal Lobe Epilepsy and Hippocampal Sclerosis? A Histopathological Study |
description |
Depression is the most frequent psychiatric comorbidity seen in mesial temporal lobe epilepsy (MTLE) patients with hippocampal sclerosis (HS). Moreover, the HS is the most frequent pathological hallmark in MTLE-HS. Although there is a well-documented hippocampal volumetric reduction in imaging studies of patients with major depressive disorder, in epilepsy with comorbid depression, the true role of the hippocampus is not entirely understood. This study aimed to verify if patients with unilateral MTLE-HS and the co-occurrence of depression have differences in neuronal density of the hippocampal sectors CA1–CA4. For this purpose, we used a histopathological approach. This was a pioneering study with patients having both clinical disorders. However, we found no difference in hippocampal neuronal density when depression co-occurs in patients with epilepsy. In this series, CA1 had the lowest counting in both groups, and HS ILAE Type 1 was the most prevalent. More studies using histological assessments are needed to clarify the physiopathology of depression in MTLE-HS. |
format |
article |
author |
Nathália Stela Visoná de Figueiredo Anaclara Prada Jardim Lenon Mazetto Jeana Torres Corso Duarte Sandra Mara Comper Neide Barreira Alonso Maria Helena da Silva Noffs Carla Alessandra Scorza Esper Abrão Cavalheiro Ricardo Silva Centeno Gerardo Maria de Araújo Filho Elza Márcia Targas Yacubian |
author_facet |
Nathália Stela Visoná de Figueiredo Anaclara Prada Jardim Lenon Mazetto Jeana Torres Corso Duarte Sandra Mara Comper Neide Barreira Alonso Maria Helena da Silva Noffs Carla Alessandra Scorza Esper Abrão Cavalheiro Ricardo Silva Centeno Gerardo Maria de Araújo Filho Elza Márcia Targas Yacubian |
author_sort |
Nathália Stela Visoná de Figueiredo |
title |
Do Hippocampal Neurons Really Count for Comorbid Depression in Patients With Mesial Temporal Lobe Epilepsy and Hippocampal Sclerosis? A Histopathological Study |
title_short |
Do Hippocampal Neurons Really Count for Comorbid Depression in Patients With Mesial Temporal Lobe Epilepsy and Hippocampal Sclerosis? A Histopathological Study |
title_full |
Do Hippocampal Neurons Really Count for Comorbid Depression in Patients With Mesial Temporal Lobe Epilepsy and Hippocampal Sclerosis? A Histopathological Study |
title_fullStr |
Do Hippocampal Neurons Really Count for Comorbid Depression in Patients With Mesial Temporal Lobe Epilepsy and Hippocampal Sclerosis? A Histopathological Study |
title_full_unstemmed |
Do Hippocampal Neurons Really Count for Comorbid Depression in Patients With Mesial Temporal Lobe Epilepsy and Hippocampal Sclerosis? A Histopathological Study |
title_sort |
do hippocampal neurons really count for comorbid depression in patients with mesial temporal lobe epilepsy and hippocampal sclerosis? a histopathological study |
publisher |
Frontiers Media S.A. |
publishDate |
2021 |
url |
https://doaj.org/article/144fbe02300642a3854fae6c41b6c318 |
work_keys_str_mv |
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