Do Hippocampal Neurons Really Count for Comorbid Depression in Patients With Mesial Temporal Lobe Epilepsy and Hippocampal Sclerosis? A Histopathological Study

Depression is the most frequent psychiatric comorbidity seen in mesial temporal lobe epilepsy (MTLE) patients with hippocampal sclerosis (HS). Moreover, the HS is the most frequent pathological hallmark in MTLE-HS. Although there is a well-documented hippocampal volumetric reduction in imaging studi...

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Autores principales: Nathália Stela Visoná de Figueiredo, Anaclara Prada Jardim, Lenon Mazetto, Jeana Torres Corso Duarte, Sandra Mara Comper, Neide Barreira Alonso, Maria Helena da Silva Noffs, Carla Alessandra Scorza, Esper Abrão Cavalheiro, Ricardo Silva Centeno, Gerardo Maria de Araújo Filho, Elza Márcia Targas Yacubian
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Publicado: Frontiers Media S.A. 2021
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Acceso en línea:https://doaj.org/article/144fbe02300642a3854fae6c41b6c318
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spelling oai:doaj.org-article:144fbe02300642a3854fae6c41b6c3182021-12-01T15:33:34ZDo Hippocampal Neurons Really Count for Comorbid Depression in Patients With Mesial Temporal Lobe Epilepsy and Hippocampal Sclerosis? A Histopathological Study1662-514510.3389/fnint.2021.747237https://doaj.org/article/144fbe02300642a3854fae6c41b6c3182021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnint.2021.747237/fullhttps://doaj.org/toc/1662-5145Depression is the most frequent psychiatric comorbidity seen in mesial temporal lobe epilepsy (MTLE) patients with hippocampal sclerosis (HS). Moreover, the HS is the most frequent pathological hallmark in MTLE-HS. Although there is a well-documented hippocampal volumetric reduction in imaging studies of patients with major depressive disorder, in epilepsy with comorbid depression, the true role of the hippocampus is not entirely understood. This study aimed to verify if patients with unilateral MTLE-HS and the co-occurrence of depression have differences in neuronal density of the hippocampal sectors CA1–CA4. For this purpose, we used a histopathological approach. This was a pioneering study with patients having both clinical disorders. However, we found no difference in hippocampal neuronal density when depression co-occurs in patients with epilepsy. In this series, CA1 had the lowest counting in both groups, and HS ILAE Type 1 was the most prevalent. More studies using histological assessments are needed to clarify the physiopathology of depression in MTLE-HS.Nathália Stela Visoná de FigueiredoAnaclara Prada JardimLenon MazettoJeana Torres Corso DuarteSandra Mara ComperNeide Barreira AlonsoMaria Helena da Silva NoffsCarla Alessandra ScorzaEsper Abrão CavalheiroRicardo Silva CentenoGerardo Maria de Araújo FilhoElza Márcia Targas YacubianFrontiers Media S.A.articlehistological evaluationdepressionmesial temporal epilepsyhippocampal sclerosis (HS)neuronal countNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENFrontiers in Integrative Neuroscience, Vol 15 (2021)
institution DOAJ
collection DOAJ
language EN
topic histological evaluation
depression
mesial temporal epilepsy
hippocampal sclerosis (HS)
neuronal count
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle histological evaluation
depression
mesial temporal epilepsy
hippocampal sclerosis (HS)
neuronal count
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Nathália Stela Visoná de Figueiredo
Anaclara Prada Jardim
Lenon Mazetto
Jeana Torres Corso Duarte
Sandra Mara Comper
Neide Barreira Alonso
Maria Helena da Silva Noffs
Carla Alessandra Scorza
Esper Abrão Cavalheiro
Ricardo Silva Centeno
Gerardo Maria de Araújo Filho
Elza Márcia Targas Yacubian
Do Hippocampal Neurons Really Count for Comorbid Depression in Patients With Mesial Temporal Lobe Epilepsy and Hippocampal Sclerosis? A Histopathological Study
description Depression is the most frequent psychiatric comorbidity seen in mesial temporal lobe epilepsy (MTLE) patients with hippocampal sclerosis (HS). Moreover, the HS is the most frequent pathological hallmark in MTLE-HS. Although there is a well-documented hippocampal volumetric reduction in imaging studies of patients with major depressive disorder, in epilepsy with comorbid depression, the true role of the hippocampus is not entirely understood. This study aimed to verify if patients with unilateral MTLE-HS and the co-occurrence of depression have differences in neuronal density of the hippocampal sectors CA1–CA4. For this purpose, we used a histopathological approach. This was a pioneering study with patients having both clinical disorders. However, we found no difference in hippocampal neuronal density when depression co-occurs in patients with epilepsy. In this series, CA1 had the lowest counting in both groups, and HS ILAE Type 1 was the most prevalent. More studies using histological assessments are needed to clarify the physiopathology of depression in MTLE-HS.
format article
author Nathália Stela Visoná de Figueiredo
Anaclara Prada Jardim
Lenon Mazetto
Jeana Torres Corso Duarte
Sandra Mara Comper
Neide Barreira Alonso
Maria Helena da Silva Noffs
Carla Alessandra Scorza
Esper Abrão Cavalheiro
Ricardo Silva Centeno
Gerardo Maria de Araújo Filho
Elza Márcia Targas Yacubian
author_facet Nathália Stela Visoná de Figueiredo
Anaclara Prada Jardim
Lenon Mazetto
Jeana Torres Corso Duarte
Sandra Mara Comper
Neide Barreira Alonso
Maria Helena da Silva Noffs
Carla Alessandra Scorza
Esper Abrão Cavalheiro
Ricardo Silva Centeno
Gerardo Maria de Araújo Filho
Elza Márcia Targas Yacubian
author_sort Nathália Stela Visoná de Figueiredo
title Do Hippocampal Neurons Really Count for Comorbid Depression in Patients With Mesial Temporal Lobe Epilepsy and Hippocampal Sclerosis? A Histopathological Study
title_short Do Hippocampal Neurons Really Count for Comorbid Depression in Patients With Mesial Temporal Lobe Epilepsy and Hippocampal Sclerosis? A Histopathological Study
title_full Do Hippocampal Neurons Really Count for Comorbid Depression in Patients With Mesial Temporal Lobe Epilepsy and Hippocampal Sclerosis? A Histopathological Study
title_fullStr Do Hippocampal Neurons Really Count for Comorbid Depression in Patients With Mesial Temporal Lobe Epilepsy and Hippocampal Sclerosis? A Histopathological Study
title_full_unstemmed Do Hippocampal Neurons Really Count for Comorbid Depression in Patients With Mesial Temporal Lobe Epilepsy and Hippocampal Sclerosis? A Histopathological Study
title_sort do hippocampal neurons really count for comorbid depression in patients with mesial temporal lobe epilepsy and hippocampal sclerosis? a histopathological study
publisher Frontiers Media S.A.
publishDate 2021
url https://doaj.org/article/144fbe02300642a3854fae6c41b6c318
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