Next-Generation Ultrasol Curcumin Boosts Muscle Endurance and Reduces Muscle Damage in Treadmill-Exhausted Rats

Curcumin positively affects performance during exercise and subsequent recovery. However, curcumin has limited bioavailability unless consumed in larger doses. In the current study, we examined the impact of a new formulation of curcumin, Next-Generation Ultrasol Curcumin (NGUC), which is relatively...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Emre Sahin, Cemal Orhan, Fusun Erten, Besir Er, Manutosh Acharya, Abhijeet A. Morde, Muralidhara Padigaru, Kazim Sahin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	curcumin exhaustion inflammation antioxidant exercise Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/14513562ad914b04b2cf57f99129fcae
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:14513562ad914b04b2cf57f99129fcae
record_format	dspace
spelling	oai:doaj.org-article:14513562ad914b04b2cf57f99129fcae2021-11-25T16:26:17ZNext-Generation Ultrasol Curcumin Boosts Muscle Endurance and Reduces Muscle Damage in Treadmill-Exhausted Rats10.3390/antiox101116922076-3921https://doaj.org/article/14513562ad914b04b2cf57f99129fcae2021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1692https://doaj.org/toc/2076-3921Curcumin positively affects performance during exercise and subsequent recovery. However, curcumin has limited bioavailability unless consumed in larger doses. In the current study, we examined the impact of a new formulation of curcumin, Next-Generation Ultrasol Curcumin (NGUC), which is relatively more bioavailable than natural curcumin on exhaustion time, grip strength, muscle damage parameters, and serum and muscle proteins. A total of 28 rats were randomly grouped as control (C, non-supplemented), exercise (E, non-supplemented), E+NGUC100 (supplemented with 100 mg/kg BW NGUC), and E+NGUC200 (supplemented with 200 mg/kg NGUC). Grip strength and exhaustion time were increased with NGUC supplementation (<i>p</i> < 0.0001). Creatine kinase (CK), lactate dehydrogenase (LDH), lactic acid (LA), myoglobin, malondialdehyde (MDA) concentrations were reduced in serum, and muscle tissue in NGUC supplemented groups (<i>p</i> < 0.05). In contrast, NGUC supplementation elevated the antioxidant enzyme levels compared to the non-supplemented exercise group (<i>p</i> < 0.01). Additionally, inflammatory cytokines were inhibited with NGUC administration (<i>p</i> < 0.05). NGUC decreased PGC-1α, p-4E-BP1, p-mTOR, MAFbx, and MuRF1 proteins in muscle tissue (<i>p</i> < 0.05). These results indicate that NGUC boosts exercise performance while reducing muscle damage by targeting antioxidant, anti-inflammatory, and muscle mass regulatory pathways.Emre SahinCemal OrhanFusun ErtenBesir ErManutosh AcharyaAbhijeet A. MordeMuralidhara PadigaruKazim SahinMDPI AGarticlecurcuminexhaustioninflammationantioxidantexerciseTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1692, p 1692 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	curcumin exhaustion inflammation antioxidant exercise Therapeutics. Pharmacology RM1-950
spellingShingle	curcumin exhaustion inflammation antioxidant exercise Therapeutics. Pharmacology RM1-950 Emre Sahin Cemal Orhan Fusun Erten Besir Er Manutosh Acharya Abhijeet A. Morde Muralidhara Padigaru Kazim Sahin Next-Generation Ultrasol Curcumin Boosts Muscle Endurance and Reduces Muscle Damage in Treadmill-Exhausted Rats
description	Curcumin positively affects performance during exercise and subsequent recovery. However, curcumin has limited bioavailability unless consumed in larger doses. In the current study, we examined the impact of a new formulation of curcumin, Next-Generation Ultrasol Curcumin (NGUC), which is relatively more bioavailable than natural curcumin on exhaustion time, grip strength, muscle damage parameters, and serum and muscle proteins. A total of 28 rats were randomly grouped as control (C, non-supplemented), exercise (E, non-supplemented), E+NGUC100 (supplemented with 100 mg/kg BW NGUC), and E+NGUC200 (supplemented with 200 mg/kg NGUC). Grip strength and exhaustion time were increased with NGUC supplementation (<i>p</i> < 0.0001). Creatine kinase (CK), lactate dehydrogenase (LDH), lactic acid (LA), myoglobin, malondialdehyde (MDA) concentrations were reduced in serum, and muscle tissue in NGUC supplemented groups (<i>p</i> < 0.05). In contrast, NGUC supplementation elevated the antioxidant enzyme levels compared to the non-supplemented exercise group (<i>p</i> < 0.01). Additionally, inflammatory cytokines were inhibited with NGUC administration (<i>p</i> < 0.05). NGUC decreased PGC-1α, p-4E-BP1, p-mTOR, MAFbx, and MuRF1 proteins in muscle tissue (<i>p</i> < 0.05). These results indicate that NGUC boosts exercise performance while reducing muscle damage by targeting antioxidant, anti-inflammatory, and muscle mass regulatory pathways.
format	article
author	Emre Sahin Cemal Orhan Fusun Erten Besir Er Manutosh Acharya Abhijeet A. Morde Muralidhara Padigaru Kazim Sahin
author_facet	Emre Sahin Cemal Orhan Fusun Erten Besir Er Manutosh Acharya Abhijeet A. Morde Muralidhara Padigaru Kazim Sahin
author_sort	Emre Sahin
title	Next-Generation Ultrasol Curcumin Boosts Muscle Endurance and Reduces Muscle Damage in Treadmill-Exhausted Rats
title_short	Next-Generation Ultrasol Curcumin Boosts Muscle Endurance and Reduces Muscle Damage in Treadmill-Exhausted Rats
title_full	Next-Generation Ultrasol Curcumin Boosts Muscle Endurance and Reduces Muscle Damage in Treadmill-Exhausted Rats
title_fullStr	Next-Generation Ultrasol Curcumin Boosts Muscle Endurance and Reduces Muscle Damage in Treadmill-Exhausted Rats
title_full_unstemmed	Next-Generation Ultrasol Curcumin Boosts Muscle Endurance and Reduces Muscle Damage in Treadmill-Exhausted Rats
title_sort	next-generation ultrasol curcumin boosts muscle endurance and reduces muscle damage in treadmill-exhausted rats
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/14513562ad914b04b2cf57f99129fcae
work_keys_str_mv	AT emresahin nextgenerationultrasolcurcuminboostsmuscleenduranceandreducesmuscledamageintreadmillexhaustedrats AT cemalorhan nextgenerationultrasolcurcuminboostsmuscleenduranceandreducesmuscledamageintreadmillexhaustedrats AT fusunerten nextgenerationultrasolcurcuminboostsmuscleenduranceandreducesmuscledamageintreadmillexhaustedrats AT besirer nextgenerationultrasolcurcuminboostsmuscleenduranceandreducesmuscledamageintreadmillexhaustedrats AT manutoshacharya nextgenerationultrasolcurcuminboostsmuscleenduranceandreducesmuscledamageintreadmillexhaustedrats AT abhijeetamorde nextgenerationultrasolcurcuminboostsmuscleenduranceandreducesmuscledamageintreadmillexhaustedrats AT muralidharapadigaru nextgenerationultrasolcurcuminboostsmuscleenduranceandreducesmuscledamageintreadmillexhaustedrats AT kazimsahin nextgenerationultrasolcurcuminboostsmuscleenduranceandreducesmuscledamageintreadmillexhaustedrats
_version_	1718413182751473664

Next-Generation Ultrasol Curcumin Boosts Muscle Endurance and Reduces Muscle Damage in Treadmill-Exhausted Rats

Ejemplares similares